Results 1 to 10 of about 2,239 (120)

SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of vidarabine against rotenone-induced neural cell injury [PDF]

Heliyon, 2023
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, which is distinguished by the loss of dopaminergic (DA) neurons in the substantia nigra and the formation of intraneuronal. Numerous studies showed that the damage
Lanxin Li, Yang Zhang, Zhengqian Chen, Ruyong Yao, Zhongqiu Xu, Can Xu, Fujie He, Haitao Pei, Cui Hao   +8 more
doaj   +2 more sources

Vidarabine, an anti-herpes agent, improves Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice [PDF]

Journal of Physiological Sciences, 2023
In this work, we examined the involvement of type 5 adenylyl cyclase (AC5) in cardiac dysfunction induced in mice given Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose equivalent to the circulating levels in periodontitis (PD) patients ...
Michinori Tsunoda, Ichiro Matsuo, Yoshiki Ohnuki, Kenji Suita, Misao Ishikawa, Takao Mitsubayashi, Aiko Ito, Yasumasa Mototani, Kenichi Kiyomoto, Akinaka Morii, Megumi Nariyama, Yoshio Hayakawa, Kazuhiro Gomi, Satoshi Okumura   +13 more
doaj   +2 more sources

Exploring the anticancer activities of Sulfur and magnesium oxide through integration of deep learning and fuzzy rough set analyses based on the features of Vidarabine alkaloid [PDF]

Scientific Reports
Drug discovery and development is a challenging and time-consuming process. Laboratory experiments conducted on Vidarabine showed IC50 6.97 µg∕mL, 25.78 µg∕mL, and ˃ 100 µg∕mL against non-small Lung cancer (A-549), Human Melanoma (A-375), and Human ...
Heba Askr, Marwa A. A. Fayed, Heba Mamdouh Farghaly, Mamdouh M. Gomaa, Enas Elgeldawi, Yaseen A. M. M. Elshaier, Ashraf Darwish, Aboul Ella Hassanien   +7 more
doaj   +2 more sources

Water-soluble vidarabine derivatives alleviate catecholamine-induced heart failure and arrhythmia without impairing cardiac function in mice. [PDF]

PLoS ONE
The worldwide standard guideline for treating heart failure (HF) is inhibition of the patients' chronically enhanced sympathetic nervous system activity.
Kenji Suita, Yoshio Hayakawa, Yujiro Hoshino, Wenqian Cai, Reiko Kurotani, Yoshiki Ohnuki, Yasumasa Mototani, Yoshihiro Ishikawa, Satoshi Okumura   +8 more
doaj   +2 more sources

Biochemical Characterization of an Arabinoside Monophosphate Specific 5′-Nucleotidase-like Enzyme from Streptomyces antibioticus [PDF]

Biomolecules
To investigate the function of the gene penF in the pentostatin and vidarabine (Ara-A) biosynthetic gene cluster in Streptomyces antibioticus NRRL 3238, PenF was recombinantly expressed and characterized.
Yuxue Liu, Xiaobei Liu, Xiaojing Zhang, Xiaoting Tang, Weiwei Su, Zhenyu Wang, Hailei Wang   +6 more
doaj   +2 more sources

Promising antiviral inhibitors against lumpy skin disease: A vetinformatics approach [PDF]

Open Veterinary Journal
Background: Lumpy skin disease (LSD) is a transboundary virus disease that mostly affects cattle. It has recently reported all over the world, which highlights the need for efficient control methods. LSD poses serious economic dangers worldwide. Aim:
S. Vamshi Krishna, Aniket Sarkar, Suchandan Banerjee, Anindya Sundar Panja   +3 more
doaj   +2 more sources

Biosynthesis of Arabinoside from Sucrose and Nucleobase via a Novel Multi-Enzymatic Cascade [PDF]

Biomolecules
Arabinoside and derived nucleoside analogs, a family of nucleoside analogs, exhibit diverse typically biological activities and are widely used as antibacterial, antiviral, anti-inflammatory, antitumor, and other drugs in clinical and preclinical trials.
Yuxue Liu, Erchu Yang, Xiaojing Zhang, Xiaobei Liu, Xiaoting Tang, Zhenyu Wang, Hailei Wang   +6 more
doaj   +2 more sources

Acyclovir Encephalopathy in HSV Encephalitis Elderly With Normal Renal Function [PDF]

Case Reports in Neurological Medicine
Herpes simplex virus (HSV) encephalitis is a disease treated with acyclovir (ACV). However, the neurotoxicity of ACV can lead to the development of ACV encephalopathy.
Naoko Makishi, Yasuharu Tokuda
doaj   +2 more sources

Overcoming post‐transplant graft failure and adenovirus infection in a patient with FLT3‐TKD‐mutated mixed‐phenotype acute leukemia: A case report [PDF]

eJHaem
Mixed‐phenotype acute leukemia (MPAL) with FLT3‐TKD mutations is a rare and challenging subtype of leukemia. Effective management strategies are crucial for improving patient outcomes.
Yusuke Takada, Shuhei Kurosawa, Toshimitsu Ueki, Yuho Najima, Satoshi Wakita, Hiroki Yamaguchi, Takako Yokota, Masaki Hibi, Ayumi Hirahara, Tsutomu Yoshida, So Okubo, Moe Masuda, Hitomi Nakayama, Aki Sakurai, Chisako Ito, Yoshinobu Aisa, Tomonori Nakazato   +16 more
doaj   +2 more sources

Dengue Virus Inhibitors as Potential Broad-Spectrum Flavivirus Inhibitors [PDF]

Pharmaceuticals
Background. Flaviviruses spread from endemic to non-endemic areas, causing illness in millions of people worldwide. The lack of effective therapies and the rapid expansion of flaviviral infections worldwide emphasize the importance of finding effective ...
Larisa Ivanova, Krystyna Naumenko, Margus Varjak, Sandra Koit, Yehudit Morozovsky, Andres Merits, Mati Karelson, Eva Zusinaite   +7 more
doaj   +2 more sources