Results 11 to 20 of about 2,258 (135)

Successful treatment of acyclovir‐resistant herpes simplex virus infection with amenamevir in a patient who received umbilical cord blood transplantation for T‐cell prolymphocytic leukemia [PDF]

eJHaem
A 34‐year‐old woman received umbilical cord blood transplantation for refractory T‐cell prolymphocytic leukemia after salvage therapy with alemtuzumab.
Yuma Kawamura, Nako Uchibori, Tomoya Arakawa, Tomoki Fujii, Shuto Negishi, Shiori Morikawa, Nobuaki Fukushima, Akio Kohno, Souichi Yamada, Yoshiko Fukui, Shuetsu Fukushi, Kazutaka Ozeki   +11 more
doaj   +3 more sources

Chemical composition, metabolomics, and functional potential of Pholiota nameko pre-cooking liquid [PDF]

Scientific Reports
The liquid generated during the pre-cooking process of Pholiota nameko is frequently considered waste, and its large-scale disposal may pose environmental risks.
Yongbin Meng, Jing Xue, Lirong Zhang, Xiaoqi Ouyang, Sitian Zhou, Lei Feng, Chengyu Zheng, Guoliang Chen, Yuanyuan Zhang, Xiaolong He   +9 more
doaj   +2 more sources

A Screening Study Identified Decitabine as an Inhibitor of Equid Herpesvirus 4 That Enhances the Innate Antiviral Response [PDF]

Viruses
Equid herpesvirus 4 (EHV-4) is a common respiratory pathogen in horses. It sporadically induces abortion or neonatal death. Although its contribution in neurological disorders is not clearly demonstrated, there is a strong suspicion of its involvement ...
Camille Normand, Côme J. Thieulent, Christine Fortier, Gabrielle Sutton, Catherine Senamaud-Beaufort, Laurent Jourdren, Corinne Blugeon, Pierre-Olivier Vidalain, Stéphane Pronost, Erika S. Hue   +9 more
doaj   +2 more sources

Production of Value-Added Arabinofuranosyl Nucleotide Analogues from Nucleoside by an In Vitro Enzymatic Synthetic Biosystem [PDF]

Biomolecules
Arabinofuranosyl nucleotide analogue (arabinoside) and the derived compounds, a family of nucleoside analogues, exhibit diverse, typically biological activities and are widely used as antibacterial, antiviral, anti-inflammatory, and antitumor drugs in ...
Yuxue Liu, Xiaojing Zhang, Erchu Yang, Xiaobei Liu, Weiwei Su, Zhenyu Wang, Hailei Wang   +6 more
doaj   +2 more sources

Early-onset herpes simplex encephalitis type 1 triggered by COVID-19 disease: A case report [PDF]

Radiology Case Reports
Coronavirus disease 2019 (COVID-19) causes a systemic inflammatory response and a temporary immunosuppression of hosts. Several reports have showed that reactivation of herpes simplex virus type 1 (HSV-1) is strongly associated with COVID-19.
Kai Inoue, Hanako Aoki, Shuta Toru, Yu Hatano, Reina Imase, Hiroshi Takasaki, Michiko Tanaka, Saori Adachi, Hiroaki Yokote, Hideki Akiyama, Michio Yamane   +10 more
doaj   +2 more sources

Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [PDF]

PLoS Pathogens
Lumpy skin disease (LSD) is an emerging transboundary disease caused by lumpy skin disease virus (LSDV), posing significant threats to global cattle health in the absence of validated drugs. Here, we constructed a recombinant LSDV (rLSDV) expressing both
Zuxin Gong, Jiaqi Dai, Hailong Qu, Yongxin Hu, Fanqi Sun, Chenchen Liu, Xin Li, Chunyan Feng, Zhiliang Wang, Zhen Yang, Gongguan Liu   +10 more
doaj   +2 more sources

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration. [PDF]

Chembiochem
In tRNA aminoacylated nucleosides represent the central transfer unit of amino acids. An occurring 2′‐3′‐transaminoacylation is biomimetically exploited to successfully synthesize nucleosidic acid esters. This approach can be further expanded on sulfonic acid esters, which has the potential of a broad range of stereo‐ and regio‐controlled modifications
Kurrle NJ, Seifert CJB, Hampel N, Rauch T, Thoma M, Parziale LV, Ebeling MSR, Berthold D, Trapp O.   +8 more
europepmc   +2 more sources

Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2

Viruses, 2021
Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is ...
Lauren A. Sadowski, Rista Upadhyay, Zachary W. Greeley, Barry J. Margulies   +3 more
doaj   +1 more source

Antiviral therapy for herpes simplex virus encephalitis: Systematic review and meta-analysis of randomized control trials

Journal of Applied Sciences and Clinical Practice, 2021
Background: Herpes simplex virus (HSV) infection of the brain is treated with antiviral drugs such as acyclovir. A summary of randomized control trials (RCTs) of antiviral drugs against HSV encephalitis has not been put forward yet. We aimed to determine
Sridhar Amalakanti, Sri Harsha Boppana, Nagarjuna Sivaraj, Kesava Venkata Raman Arepalli, Tarun Kumar Suvvari   +4 more
doaj   +1 more source

Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism. [PDF]

PLoS ONE, 2012
To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase;
Louise Egeblad, Martin Welin, Susanne Flodin, Susanne Gräslund, Liya Wang, Jan Balzarini, Staffan Eriksson, Pär Nordlund   +7 more
doaj   +1 more source