Results 121 to 130 of about 454,759 (354)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Le designer de jeux vidéo comme agent d’évolution à l’ère du jeu casual

Sciences du Jeu, 2015
This article aims to demonstrate the importance of video game designers as agent of progress. This work is based on a study whose main purpose is to better define casual games while using the video game designers' professional knowledge.
Laureline Chiapello
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Learning and Games [PDF]

, 2008
Part of the Volume on the Ecology of Games: Connecting Youth, Games, and Learning In this chapter, I argue that good video games recruit good learning and that a game's design is inherently connected to designing good learning for players. I start with a
James Paul Gee
core  

Dual‐Target ROS‐Driven Spatiotemporal Senolysis for Vascular Repair and Immune Microenvironment Reprogramming in the Treatment of Ocular Fundus Neovascularization

Advanced Science, EarlyView.
We developed a senolytic approach using procyanidin C1 (PCC1)‐loaded platform, a clinically established and safe hyaluronic acid‐based scaffold, to selectively eliminate senescent endothelial and microglial cells. This dual‐targeting strategy significantly suppresses pathological neovascularization and promotes vascular repair, presenting a safe and ...
Yali Zhou, Tianxing Chen, Peiyu Liu, Kangjia Lv, Yifan Wang, Xiaoqian Wang, Junwei Fang, Chong Chen, Zhaoyang Wang, Fang Wei, Xun Xu   +10 more
wiley   +1 more source

Book review: From N00b to Community Organizer: A Review of Kurt Squire's 'Video Games and Learning: Teaching and Participatory Culture in the Digital Age (review by Michelle A. Hoyle)

Journal of Interactive Media in Education, 2012
Can we learn socially and academically valuable concepts and skills from video games?  How can we best teach the "gamer generation"?  This accessible book describes how educators and curriculum designers can harness the participatory nature of ...
Kurt Squire
doaj   +1 more source

“Playing RPG Maker”? Amateur Game Design and Video Gaming

DiGRA Digital Library, 2016
Game creation tools like Game Maker or RPG Maker democratize game making and facilitate the development of amateur game design. The best known among these programs have dynamic web-communities with active members making thousands of games. However, as of now, there is little research on amateur game design except for modding or education fields.
openaire   +2 more sources

Meter‐Scale Ultra‐Large‐Area Flexible Electroluminescent Devices Enabled by Aerosol Spraying

Advanced Science, EarlyView.
This work presents a simple aerosol spraying method using modified luminescent ink to fabricate meter‐scale flexible alternating current electroluminescent (ACEL) devices. Enhanced particle dispersibility and film uniformity yield impressive brightness up to 500 cd m−2, positioning these devices as effective luminous navigation signs for industrial ...
Hao Song, Liang Yi, Lixiang Huang, Wajid Ali, Linhan Cai, Chao Wang, Jianhua Huang, Ziwei Li, Anlian Pan   +8 more
wiley   +1 more source

Problematic Use of Video Games in Schooled Adolescents: The Role of Passion

Behavioral Sciences
The present study aims to determine the predictive value of sociodemographic, academic, educational clinical psychological variables—ADHD diagnosis, emotional self-regulation, passion and emotional and behavioural symptoms—and modality of use of video ...
José María Faílde Garrido, María Dolores Dapía Conde, Manuel Isorna Folgar, Fátima Braña Rey   +3 more
doaj   +1 more source

World of Warcraft: A Family Therapist\u27s Journey into Scapegoated Culture [PDF]

, 2014
Relational (online) video games are lucrative business. The extremely popular Massive Multiplayer Online Role Playing Game, World of Warcraft, boasts over eight million paying users. Video games are also a lightning rod for criticism and contempt by news
Jordan, Nickolas
core   +1 more source