Results 51 to 60 of about 1,314,530 (315)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Las obras de acondicionamiento del Salto del Mont-Cenis
Informes de la Construccion, 1969 La capacidad de la nueva presa del Mont-Cenis ha aumentado con estas obras desde 32 hasta 320 millones de m3, permitiendo el abastecimiento de una energía potencial de 650.000 millones de Mp x m.
Georges Vié
doaj +1 more source
Long-run equilibria, dominated strategies, and local interactions [PDF]
The present note revisits a result by Kim and Wong (2010) showing that any strict Nash equilibrium of a coordination game can be supported as a long run equilibrium by properly adding dominated strategies. We show that in the circular city model of local
Simon Weidenholzer
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Perforación de galerías sin empleo de explosivos
Informes de la Construccion, 1967 La perforación de galerías presenta distintos problemas según la naturaleza del terreno y la ubicación de la obra. La imposibilidad de emplear tiros de mina en perforaciones bajo zonas urbanas, da lugar al empleo cada vez más frecuente de la maquinaria ...
Georges Vié
doaj +1 more source
Why evolution does not always lead to an optimal proto-language.An approach based on the replicator dynamics [PDF]
Sender–receiver models in the style of Lewis (1969), Hurford (1989), or Nowak and Krakauer (1999) can be used to explain meaning of signals in situations of cooperative interaction.
Christina Pawlowitsch
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Métodos modernos de excavación de galerías y túneles
Informes de la Construccion, 1967 El avance extraordinario registrado en los últimos años en el campo de las obras públicas se debe, fundamentalmente, al empleo masivo de maquinaria auxiliar en cualquier tajo de una obra.
Georges Vié
doaj +1 more source
Naked exclusion in the lab: The case of sequential contracting [PDF]
In the context of the naked exclusion model of Rasmusen, Ramseyer and Wiley (1991) and Segal and Whinston (2000b), we examine whether sequential contracting is more conducive to exclusion in the lab, and whether it leads to lower exclusion costs for the ...
Jan Boone +2 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source