Results 61 to 70 of about 582,403 (259)

Perforación de galerías sin empleo de explosivos

open access: yesInformes de la Construccion, 1967
La perforación de galerías presenta distintos problemas según la naturaleza del terreno y la ubicación de la obra. La imposibilidad de emplear tiros de mina en perforaciones bajo zonas urbanas, da lugar al empleo cada vez más frecuente de la maquinaria ...
Georges Vié
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Colloque "Le parcours en question"

open access: yes, 2017
Cher-e-s collègues, Nous vous annonçons avec plaisir la tenue du colloque "Le parcours en question : comprendre les tensions entre les logiques individuelles, collectives et institutionnelles".
AFS RT 22 Parcours de vie
core  

Métodos modernos de excavación de galerías y túneles

open access: yesInformes de la Construccion, 1967
El avance extraordinario registrado en los últimos años en el campo de las obras públicas se debe, fundamentalmente, al empleo masivo de maquinaria auxiliar en cualquier tajo de una obra.
Georges Vié
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Prospezioni Geofisiche lungo le Vie Appia Antica e Severiana

open access: yes, 2005
Nell'ambito della ricerca "Le vie romane del Mediterraneo" è stato eseguito uno studio sulle antiche vie consolari di Roma, la via Appia antica e la via Severiana mediante l'esecuzione di campagne di misure geofisiche, finalizzate all'individuazione di ...
Urbini, S.   +4 more
core   +2 more sources

Perforación y revestimiento de la galería de Laval de Cère II (Francia)

open access: yesInformes de la Construccion, 1966
El aprovechamiento hidroeléctrico de Cère II constituye un complejo importante que explota EDF. Situado en el macizo central, montañoso, presenta las características generales del tipo, esto es, aquí las galerías son la parte más importante.
Georges Vié
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Los progresos recientes del material auxiliar en la perforación de galerías

open access: yesInformes de la Construccion, 1964
Es muy frecuente, en los trabajos de ingeniería civil, tener que recurrir a la perforación de galerías, principalmente en las obras hidráulicas, así como también en la construcción de ferrocarriles y carreteras en terrenos de relieve acusado.
Georges Vié
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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