Results 81 to 90 of about 414,171 (309)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Los progresos recientes del material auxiliar en la perforación de galerías

Informes de la Construccion, 1964
Es muy frecuente, en los trabajos de ingeniería civil, tener que recurrir a la perforación de galerías, principalmente en las obras hidráulicas, así como también en la construcción de ferrocarriles y carreteras en terrenos de relieve acusado.
Georges Vié
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Auditory stimulation at individual gamma frequency enhances cognitive performance

Scientific Reports
Personalized auditory gamma stimulation may sharpen human cognition; however, behavioral evidence remains sparse. Here, we recruited 29 healthy adults (15 men; age range, 20–49 years) with no self-reported history of psychiatric disorders, and identified
Yusuke Yokota, Kenta Tanaka, Ming Chang, Shin Koike, Shinya Fujii, Yasushi Naruse, Yasuhiko Imamura   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Nostalgia Brain-Music Interface for enhancing nostalgia, well-being, and memory vividness in younger and older individuals

Scientific Reports
Music-evoked nostalgia has the potential to assist in recalling autobiographical memories and enhancing well-being. However, nostalgic music preferences vary from person to person, presenting challenges for applying nostalgia-based music interventions in
Yuna Sakakibara, Tomohiro Kusutomi, Sotaro Kondoh, Takahide Etani, Saori Shimada, Yasuhiko Imamura, Yasushi Naruse, Shinya Fujii, Takuya Ibaraki   +8 more
doaj   +1 more source

Rompeolas en el estuario del río Adour, Bayona

Informes de la Construccion, 1964
La importancia marítima del puerto de Bayona (Francia) no ha tenido gran importancia hasta estos liltinios años. Las instalaciones industriales, azufre, gas y otros recursos naturales de esta zona costera han venido aumentando continuamente hasta ...
Georges Vié
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Salto de Vinon, Francia

Informes de la Construccion, 1966
El aprovechamiento hidroeléctrico del arroyo Verdón, afluente más importante del río Durance, se realiza por medio del salto de Vinon. Las aguas combinadas de la restitución y embalse de Gréoux suministrarán un caudal regulado al canal de Provenza, para ...
G. Vié
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source