Results 251 to 260 of about 15,083 (304)

Modeling mTORopathy-related epilepsy in cultured murine hippocampal neurons using the multi-electrode array

Heuvelmans AM, Onori MP, Frega M, de Hoogen JD, Nel E, Elgersma Y, van Woerden GM.   +6 more
europepmc   +1 more source

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Comparison of Cosyntropin, Vigabatrin, and Combination Therapy in New-Onset Infantile Spasms in a Prospective Randomized Trial

Journal of Child Neurology, 2022
Objective: In a randomized trial, we aimed to evaluate the efficacy of cosyntropin injectable suspension, 1 mg/mL, compared to vigabatrin for infantile spasms syndrome.
K. Knupp, J. Coryell, Rani K. Singh, W. Gaillard, R. Shellhaas, S. Koh, W. Mitchell, C. Harini, J. Millichap, Alison S. May, D. Dlugos, K. Nickels, J. Mytinger, C. Keator, Elissa G. Yozawitz, N. Singhal, J. Lockrow, Jacob F. Thomas, E. Juarez-colunga   +18 more
semanticscholar   +1 more source

Risk of vigabatrin‐associated brain abnormalities on MRI: A retrospective and controlled study

Epilepsia, 2021
Vigabatrin (VGB) is the first‐line treatment for infantile spasms (IS). Previous studies have shown that VGB exposure may cause vigabatrin‐associated brain abnormalities on magnetic resonance imaging (MRI) (VABAM).
Yong Xu, L. Wan, Wen He, Yang-Yang Wang, Qiuhong Wang, Xiao-mei Luo, Kun Liu, Xiao-Yan Yang, Jing Wang, Xiu-yu Shi, Guang Yang, Fang Han, Jing Gao, L. Zou   +13 more
semanticscholar   +1 more source

Clinical Utility of Electroretinograms for Evaluating Vigabatrin Toxicity in Children.

Journal of pediatric ophthalmology and strabismus, 2021
PURPOSE To determine changes in the clinical treatment of pediatric patients taking vigabatrin for seizure control in response to results of electroretinogram (ERG) performed for retinal toxicity screening.
Anne Strong, Ashley Sturdy, Emily A. McCourt, R. Braverman, Jasleen K. Singh, R. Enzenauer, Jennifer L. Jung   +6 more
semanticscholar   +1 more source

Visual field defects after vigabatrin treatment during infancy: retrospective population‐based study

Developmental Medicine & Child Neurology, 2021
To investigate the prevalence of vigabatrin‐attributed visual field defect (VAVFD) in infantile spasms and the utility of optical coherence tomography (OCT) in detecting vigabatrin‐related damage.
Henna Jonsson, M. Lehto, S. Vanhatalo, E. Gaily, T. Linnankivi   +4 more
semanticscholar   +1 more source

Fulminant vigabatrin toxicity during combination therapy with adrenocorticotropic hormone for infantile spasms: Three cases and review of the literature

Epilepsia, 2020
Vigabatrin (VGB), adrenocorticotropic hormone (ACTH), and prednisone are first‐line treatments for infantile spasms (IS). A recent study reported benefits from the use of combination VGB and hormonal therapy over hormonal treatment alone in IS.
S. Bhalla, K. Skjei
semanticscholar   +1 more source