Results 71 to 80 of about 14,898 (265)
Nonvesicular Inhibitory Neurotransmission via Reversal of the GABA Transporter GAT-1 [PDF]
, 2007 SummaryGABA transporters play an important but poorly understood role in neuronal inhibition. They can reverse, but this is widely thought to occur only under pathological conditions. Here we use a heterologous expression system to show that the reversal
Díez-Sampedro, Ana +3 more
core +1 more source
Three-dimensional neurorehabilitation: a different perspective [PDF]
, 2015 The authors have narrated their perspective on rehabilitation of neurological disabilities based upon their experiences in three different regions of the globe, hence the word three dimensional .
Mitchell Jenkins, Randolph +1 more
core +1 more source
Annals of Neurology, Volume 98, Issue 1, Page 48-61, July 2025.Objective Gain‐of‐function (GoF) variants in KCNT1 encoding for potassium channels are associated with different epilepsy phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), other early infantile developmental and epileptic encephalopathies, and focal epilepsy.
Marina Trivisano +13 more
wiley +1 more source
Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy. [PDF]
, 2019 Aminoacyl-tRNA synthetases (ARSs) function to transfer amino acids to cognate tRNA molecules, which are required for protein translation. To date, biallelic mutations in 31 ARS genes are known to cause recessive, early-onset severe multi-organ diseases ...
Accogli, Andrea +28 more
core +2 more sources
European Journal of Neurology, Volume 32, Issue 7, July 2025.This prospective cross‐sectional study screened 27 patients with inflammatory polyradiculoneuropathy (IPN) for signs of intracranial hypertension (IH) using multimodal ophthalmological assessments (fundoscopy, perimetry, OCT, ultrasonography). Signs of IH were identified in 37% of patients.
Stefan Macher +13 more
wiley +1 more source
Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. [PDF]
, 2018 There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models.
Dang, Hoa +4 more
core +3 more sources
Chemistry – A European Journal, Volume 31, Issue 32, June 6, 2025.Fused nitrogen‐bridgehead N,O‐acetals receive specific emphasis as pivotal scaffolds due to their significant role in the bioactivity of medicinally relevant molecules. Significant approaches have been reported on their role as key synthetic building blocks/motifs in the construction of complex organic molecules and their utility as chiral auxiliaries ...
Alexis D. Kouvelas +2 more
wiley +1 more source
Vigabatrin dosing during haemodialysis
Seizure, 1996 The antiepileptic drug vigabatrin has shown efficacy in the treatment of patients with refractory epilepsy. Unlike many other antiepileptics it is not bound to plasma protein and mainly eliminated by the kidney. Although the therapeutic and toxic serum concentration range is not clearly defined and efficacy and toxicity are not closely correlated with ...
Rudolf Ritz +3 more
openaire +3 more sources
Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus [PDF]
, 2005 Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain.
Kullmann, D.M. +4 more
core +1 more source
Allergic skin rash with lamotrigine and concomitant valproate therapy - Evidence for an increased risk [PDF]
, 1996 Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had ...
Duncan, JS +4 more
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