Results 71 to 80 of about 11,941 (202)
Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. [PDF]
, 2011 Infantile spasms is an epileptic encephalopathy of early infancy with specific clinical and electroencephalographic (EEG) features, limited treatment options, and a poor prognosis.
Arnason, Barry GW +10 more
core +2 more sources
Epilepsia, EarlyView.Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire +9 more
wiley +1 more source
Guideline Update to Treatment of Infantile Spasms
Pediatric Neurology Briefs, 2012 The Guideline Developmental Subcommittee of the AAN and the Practice Committee of the CNS update the 2004 practice parameter on treatment of infantile spasms (IS).
J Gordon Millichap
doaj +1 more source
Longer Duration of Epilepsy and Earlier Age at Epilepsy Onset Correlate with Impaired Cognitive Development in Infancy [PDF]
, 2009 We assessed the impact of age at onset of epilepsy and duration and frequency of seizures on cognitive development in children less than 3 years old. Retrospective analysis was conducted on clinical data and neuropsychological testing of 33 infants with ...
Vendrame, Martina
core +2 more sources
Epilepsia, EarlyView.Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls +13 more
wiley +1 more source
Vigabatrin Intractable Epilepsy
Pediatric Neurology Briefs, 1992 The relationship between vigabatrin dosage and plasma concentrations, platelet GABA-transaminase inhibition and seizure reduction in 16 children with refractory epilepsy was studied at the University of Cantabria, Santander, Spain.
J Gordon Millichap
doaj +1 more source
Trends in long-term prescribing of dependence forming medicines [PDF]
, 2019 Using patient-level primary care data to estimate the extent to which antidepressant medicines are prescribed to people continuously for long periods of time.
McManus, S. +3 more
core
Topiramate in the treatment of severe myoclonic epilepsy in infancy [PDF]
, 2000 The aim of this study was to assess the effectiveness of topiramate (TPM) as an add-on regimen in reducing seizure rate in a population sample of patients diagnosed with severe myoclonic epilepsy in infancy (SME). Eighteen patients were evaluated.
Nieto-Barrera, M +4 more
core +1 more source
Topiramate for the treatment of neonatal seizures and beyond
Epilepsia, EarlyView.Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley +1 more source
UK Multicenter Randomized Trial of Hormonal Treatments Vs Vigabatrin for Infantile Spasms
Pediatric Neurology Briefs, 2010 The UK Infantile Spasms Multicenter Study previously showed that seizure control after 14 days and development at 14 months are better following hormonal treatments (prednisolone or tetracosactide depot) than following vigabatrin.
J Gordon Millichap
doaj +1 more source