Results 71 to 80 of about 15,406 (277)

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Vigabatrin (Sabril) for the Treatment of Refractory Complex Focal Seizures in Adults: Pharmacologic and Clinical Considerations [PDF]

, 2023
Taylor Gatson, Orlandria A Freemont, Rachel L. Coleman, Stewart J Lockett, Noah J Spillers, Shahab Ahmadzadeh, Omar Viswanath, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye   +9 more
openalex   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The spectrum and efficacy of antiepileptic drugs in patients with infantile spasms in Russia

Эпилепсия и пароксизмальные состояния, 2018
Recently, the International League Against Epilepsy (ILAE) defined epileptic spasms as a separate type of seizures. According to the international recommendations, the treatment of infantile  spasms (IS) begins with hormones or vigabatrin (in the cases ...
T. G. Okhapkina, I. V. Shuljakova, E. S. Ilina, G. V. Kalmykova, M. V. Prytkina, E. D. Belousova   +5 more
doaj   +1 more source

Prevalence and incidence of infantile epileptic spasms syndrome in India: A systematic review and meta‐analysis

Epilepsia Open, EarlyView.
Abstract Objectives Infantile epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy of infantile onset. While epidemiological data from Western countries and global estimates are available, consolidated evidence on the burden of IESS in India remains limited.
Akanksha Singh, Parth Lal, Mohammed Safeer V.S., Atishay Jain, Priyanka Madaan, Jitendra Kumar Sahu, Dipika Bansal   +6 more
wiley   +1 more source

Vigabatrin-Associated “Acute Encephalopathy”

Pediatric Neurology Briefs, 2000
A 6-month-old girl with Alexander disease and hydrocephalus, treated at Children’s Hospital, Tubingen, Germany, developed acute encephalopathy within 3 days of starting vigabatrin (VGB).
J Gordon Millichap
doaj   +1 more source

Einfluss des Antiepileptikums Topiramat auf die mit Transkranieller Magnetstimulation gemessene Exzitabilität des menschlichen Motorkortex [PDF]

, 2003
Die Transkranielle Magnetstimulation (TMS) gilt heute in der neurophysiologischen Diagnostik als etabliertes Verfahren zur Untersuchung zentralmotorischer Bahnen und zur Erfassung der Erregbarkeit des menschlichen Motorkortex. In in-vivo-Studien wurden
Reis, Janine, Rosenow, Felix (Prof. Dr. med.)   +1 more
core   +1 more source

Retinal structure and function in vigabatrin‐treated adult patients with refractory complex partial seizures

Epilepsia, 2016
Evaluate visual‐field and retinal‐structure changes following adjunctive vigabatrin treatment in vigabatrin‐naive adults with refractory complex partial seizures (rCPS).
R. Sergott, Chris A. Johnson, K. Laxer, R. Wechsler, K. Cherny, J. Whittle, G. Feng, Deborah Lee, J. Isojarvi   +8 more
semanticscholar   +1 more source

Distinctive genetic architecture of infantile epileptic spasms syndrome compared to self‐limited infantile epilepsy by trios whole‐exome sequencing

Epilepsia Open, EarlyView.
Abstract Objective Infantile epileptic spasms syndrome (IESS) and self‐limited infantile epilepsy (SeLIE) are both genetically heterogeneous disorders during infancy with distinct prognoses. To better define the genetic spectrum of IESS, we performed a comparative genetic analysis using SeLIE cases as a reference group. Methods We performed whole‐exome
Yihong Sun, Ningning Chen, Congjie Chen, Weitian Lu, Qian Wan, Tingsong Li, Yupeng Cun   +6 more
wiley   +1 more source