Results 81 to 90 of about 15,083 (304)
Evaluate visual‐field and retinal‐structure changes following adjunctive vigabatrin treatment in vigabatrin‐naive adults with refractory complex partial seizures (rCPS).
R. Sergott+8 more
semanticscholar +1 more source
Clinical pharmacology of vigabatrin. [PDF]
1. Upon oral administration vigabatrin is rapidly absorbed. Plasma elimination half‐life ranges between 5 and 7 h in normal volunteers. Vigabatrin is eliminated primarily via the kidneys with about 65% of the administered dose found unchanged in the urine within 24 h. Kinetics are dose‐linear within the range of usual therapeutic doses. 2.
openaire +3 more sources
Abstract Background Biallelic loss‐of‐function variants in PI4K2A have been associated with a neurodevelopmental disorder characterized by seizures and movement disorders, including orofacial dyskinesia. However, only 4 cases have been reported. Orolingual dyskinesia—defined as involuntary movements of the mouth and tongue—is observed in various ...
Reza Maroofian+9 more
wiley +1 more source
Visual Fields in Mothers and Children Exposed in Utero to Vigabatrin
Three mothers with 4 children exposed to vigabatrin in utero (but not breast fed) underwent perimetry and imaging of the retinal nerve fiber layer (RNFL) at the University Hospital of Wales and School of Optometry, Cardiff, UK.
J Gordon Millichap
doaj +1 more source
Einfluss des Antiepileptikums Topiramat auf die mit Transkranieller Magnetstimulation gemessene Exzitabilität des menschlichen Motorkortex [PDF]
Die Transkranielle Magnetstimulation (TMS) gilt heute in der neurophysiologischen Diagnostik als etabliertes Verfahren zur Untersuchung zentralmotorischer Bahnen und zur Erfassung der Erregbarkeit des menschlichen Motorkortex. In in-vivo-Studien wurden
Reis, Janine+1 more
core +1 more source
A geriatrician's approach to managing the complex older adult with obesity
Abstract The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight‐loss attempts during the middle years of life ...
Shenbagam Dewar
wiley +1 more source
Developmental Outcomes of Infants Treated With Combination Therapy for Infantile Spasms
The International Collaborative Infantile Spasms Study (ICISS) Group evaluated the developmental and epilepsy outcomes at 18 months following hormonal treatment alone or hormonal treatment combined with vigabatrin.
Jacqueline Wolak, Sunita N Misra
doaj +1 more source
Diagnosis and treatment of occipital brain lesions in children
Occipital brain lesions in children represent a diagnostic challenge due to the large spectrum of etiologies and overlapping clinical features. This review analyses common and less common causes of occipital brain lesions in children, including malformative, vascular, genetic/metabolic, infectious, inflammatory, and neoplastic conditions.
Luca Bartolini+4 more
wiley +1 more source
Psychoses and Epilepsy: Paradoxical Normalization
Five children aged 2.5 to 9 years who developed paradoxical, or forced normalization (acute psychiatric symptoms with abrupt cessation of seizures and normalized EEG) are reported from the Shaare Zedek Medical Center, Jerusalem.
J Gordon Millichap
doaj +1 more source