Results 191 to 200 of about 66,916 (254)

Prostatic stromal tumors with uncertain malignant potential: A scoping review of clinical challenges and management strategies

UroPrecision, EarlyView.
Abstract Prostatic stromal tumor of uncertain malignant potential (STUMP) is a rare neoplasm arising from specialized prostatic stromal cells with a broad range of histologic patterns and unpredictable clinical behavior. It is often challenging to distinguish STUMP from prostatic stromal sarcoma due to morphological similarities, necessitating specific
Ibrahim A. Khalil, Abdullah M. Al‐Jubouri, Khaled Murshed, Ahmad R. Al‐Qudimat, Majd Alkabbani, Nagy Younes, Khalid Al Jalham, Khalid Al Rumaihi   +7 more
wiley   +1 more source

Modification of Vimentin Polypeptides during Mitosis

Cold Spring Harbor Symposia on Quantitative Biology, 1982
R. Bravo, S. J. Fey, P. Mose Larsen, J. E. Celis   +3 more
openaire   +2 more sources

Mass spectrometry‐based mitochondrial proteomics for cancer biomarker discovery

VIEW, EarlyView.
Figure.1 Schematic diagram of MS‐based mitochondrial proteomics for cancer biomarker discovery. The workflow highlights the integration of advanced technological platforms in mitochondrial proteomics and their application in cancer biomarker discovery.
Zheng Cao, ZiKun Song, Weijie Zhou, Xiaohui Liu, Yanling Liu, Peng R. Chen, Kun Qian   +6 more
wiley   +1 more source

Cyotoxicity of Etidronate as an Endodontic Chelator Against Periodontal Ligament Fibroblast

Australian Endodontic Journal, EarlyView.
ABSTRACT Etidronic acid (HEBP) causes fewer alterations in dentine and can be used mixed with sodium hypochlorite during root canal preparation. This study investigated the cytotoxicity effects of the HEDP and EDTA on human periodontal ligament fibroblast cells. Primary culture was established from human periodontal ligament tissue of one donor and was
Bruno Vila Nova de Almeida, Patrícia de Almeida Rodrigues, Geovanni Pereira Mitre, Maria Sueli da Silva Kataoka, João de Jesus Viana Pinheiro, Talita Tartari, Oscar Faciola Pessoa   +6 more
wiley   +1 more source

Three‐dimensional patient‐derived endometriosis model for drug evaluation

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In this study, we developed a coculturing model with stromal cells and epithelial organoids to mimic the endometriotic lesion and for further evaluation of drug effects. Abstract Introduction Endometriomsis (EMs) is a complex and chronic gynecological disease characterized by distressing symptoms.
Yuqi Li, Wei Shao, Xiaoxiao Gao, Yongxing Wang, Jinzhi Li, Liansuo Zhang, Yanyan Xing, Wentao Su, Yan Cheng, Li Wang, Songping Liu   +10 more
wiley   +1 more source

Circulating tumour cells (CTCs) in haematological malignancies: Advances in biology and clinical relevance with a focus on multiple myeloma

British Journal of Haematology, EarlyView.
Spatial heterogeneity limits the sensitivity of bone marrow biopsies, resulting in false‐negative findings. Circulating tumour cells (CTCs) provide a systemic, stratified monitoring approach, using flow cytometry for high tumour burden and EuroFlow or allele‐specific oligonucleotide PCR (ASO‐PCR) for minimal residual disease to enable early relapse ...
Chin‐Mu Hsu, Jui‐Feng Hsu, Jee‐Fu Huang, Yi‐Chang Liu   +3 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

Cancer Science, EarlyView.
Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu   +6 more
wiley   +1 more source

Tumor‐Associated Macrophage‐Derived CXCL1 Promotes Endometrial Cancer Progression Through the CXCR2/NF‐κB Pathway

Cancer Science, EarlyView.
CXCL1 secreted by M2 macrophages induced EMT of EC cells through the CXCR2/NF‐κB pathway; CXCR2 expression was predominantly observed in the epithelial compartment, whereas CXCL1 expression was primarily localized in the stromal region; Neutralization of M2 macrophage‐secreted CXCL1 and inhibiting the NF‐κB pathway can inhibit EC progression in vivo ...
Ruiqi Xia, Dingtian Qi, Boshu Ji, Yisheng Dai, Xianchao Kong   +4 more
wiley   +1 more source

CALR/HIF‐1α Positive Feedback Loop Drives CALR Upregulation to Promote EMT‐Mediated Bladder Cancer Progression via ROS/AKT Axis

Cancer Science, EarlyView.
This study first found that the high expression of CALR is due to a novel positive feedback loop with HIF‐1α in the tumor microenvironment: CALR stabilizes HIF‐1α protein, while HIF‐1α transcriptionally upregulates CALR expression, thereby self‐sustaining its high expression levels in BLCA.
Xintao Tian, Yue Liu, Zhiyuan Mi, Ye Liang, Zhao Zhang, Xiaocheng Ma, Huiqing Jia, Yuxuan Cao, Zhijuan Liang, Shaonan Yang, Guofeng Ma, Haitao Niu   +11 more
wiley   +1 more source