Results 201 to 210 of about 53,171 (233)

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

LigGen-a GEN-AI based ligand generation approach for de-novo drug design. [PDF]

Sci Rep
Yadav A, Murugan NA.
europepmc   +1 more source

Structural insights into xyloglucan recognition by an ABC transporter from a Gram‐positive, thermophilic bacterium

The FEBS Journal, EarlyView.
Athe_2052 is an ABC transporter substrate‐binding protein that recognizes xyloglucan heptasaccharide (XXXG), a soluble breakdown product of plant xyloglucan. The crystal structure of Athe_2052, together with binding assays and computational modeling, shows how XXXG is recognized by this sugar transporter.
Hansen Tjo, Virginia Jiang, Philip D. Jeffrey, Angela Zhu, A. James Link, Jerelle A. Joseph, Jonathan M. Conway   +6 more
wiley   +1 more source

The LiPP Benchmark Set for Modeling Lipid-Protein Complexes: Comparison of Co-Folding and Docking Methods. [PDF]

J Chem Inf Model
Yang LY, Gupta S, Mullininx LN, McShan AC.   +3 more
europepmc   +1 more source

Insights into tandem dioxygenases—copper radical oxidases in fungal Phytopathogens of the Colletotrichum acutatum species complex

The FEBS Journal, EarlyView.
In Colletotrichum acutatum species complex, conserved ring‐cleavage dioxygenases located adjacent to AA5_2 enzymes were investigated as potential redox partners. Biochemical analyses identified the dioxygenases as intradiol‐cleaving enzymes preferentially oxidizing methyl‐substituted catechols, while AA5_2 enzymes displayed weak alcohol oxidase ...
Radka Končitíková, David Ribeaucourt, Mireille Haon, David Navarro, Elodie Drula, Bastien Bissaro, Jean‐Guy Berrin, Mickael Lafond   +7 more
wiley   +1 more source

Ten-year follow-up of the first left ventricular assist device implantation program in Chile: a case series. [PDF]

J Cardiothorac Surg
Pedemonte Villablanca O, Berthelon Vega P, Espinoza Reed P, Merello Norero L, Aranda Gutierrez F, Ibarra Castillo J, Novajas Balboa M, Meza Concha N, Aranguiz Santander E, Vera Peralta A.   +9 more
europepmc   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

Insect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Inorganic polyphosphate chelates Ca²⁺ but cannot substitute for ATP as an energy source for SERCA. [PDF]

Biochem Biophys Rep
Khasanov FA, Rustamova FR, Semernya EP, Akhmadkhojaeva LM, Nebesnaya KS, Rustamov KR, Baev AY.   +6 more
europepmc   +1 more source

Understanding the Meaning of a Good Death for People Living With Parkinson's Disease: Qualitative Study

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Parkinson's disease is the second most common neurodegenerative disorder globally. Despite growing attention to palliative care in Parkinson's disease, little is known about what constitutes a “good death” from the perspective of people living with Parkinson's disease (PLwPD).
Leonardo Martins, Rasa Mikelyte, Ricardo Silva Carvalho, Henrique Ballalai Ferraz, Déborah Oliveira, Julia Maria Vanelli, Natália Rocha Tardelli, Fernanda Bono Fukushima, Edison Iglesias de Oliveira Vidal   +8 more
wiley   +1 more source

Perfluorooctane sulfonate (PFOS) interferes with Cyp1a activity and dysregulates the aryl hydrocarbon receptor pathway in larval zebrafish (Danio rerio). [PDF]

Environ Pollut
Miller DH, Lachapelle A, Satbhai KM, Chien P, Borys KA, Timme-Laragy AR.   +5 more
europepmc   +1 more source