Results 21 to 30 of about 70,411 (245)

CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy

Molecular Oncology, 2020
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI‐anchored protein, was overexpressed in
Jie Sun, Dongju Feng, Huiyu Xi, Jiajing Luo, Zewei Zhou, Qinghuai Liu, Yun Chen, Qing Shao   +7 more
doaj   +1 more source

Effects of cromolyn sodium and honey on vincristine-induced neuropathic pain: An experimental study in mice [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. Chemotherapy-induced neuropathy is a significant side effect of anticancer drugs such as vincristine, leading to increased pain sensitivity and reduced quality of life. Investigations are required to reduce these adverse effects.
Moslem Najafi, Bohloul Habibi Asl, Hamideh Najafluy Mayan, Mina Islambulchilar   +3 more
doaj   +1 more source

Ginger Constituent 6-Shogaol Attenuates Vincristine-Induced Activation of Mouse Gastroesophageal Vagal Afferent C-Fibers

Molecules, 2022
Chemotherapeutic agent-induced nausea and vomiting are the severe adverse effects that are induced by their stimulations on the peripheral and/or central emetic nerve pathways. Even though ginger has been widely used as an herbal medicine to treat emesis,
Mayur J. Patil, Yongming Huang, Mingwei Yu, Xinzhong Dong, Bradley J. Undem, Shaoyong Yu   +5 more
doaj   +1 more source

Revisiting the management of chronic ITP; a randomized controlled clinical trial

Platelets, 2021
The balance between therapy effectiveness and economic efficiency in chronic immune thrombocytopenia (ITP) becomes more confusing. This single-center open label randomized controlled trial evaluates the effectiveness and safety of hydroxychloroquine in ...
Ghada E. M. Abdallah, Esam A. S. Elbiih, Douaa Sayed, Sawsan M. Moeen, Shima Gafer, Ahmad F. Thabet   +5 more
doaj   +1 more source

Dual-modified liposome codelivery of doxorubicin and vincristine improve targeting and therapeutic efficacy of glioma

Drug Delivery, 2017
Therapeutic outcome for the treatment of glioma was often limited due to drug resistance and low permeability of drug across the multiple physiological barriers, including the blood-brain barrier (BBB), and the blood-tumor barrier (BTB).
Yue Zhang, Meifang Zhai, Zhijiang Chen, Xiaoyang Han, Fanglin Yu, Zhiping Li, Xiangyang Xie, Cuiyan Han, Lian Yu, Yang Yang, Xingguo Mei   +10 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Primary bladder lymphoma, diffuse large B-cell type: Case report and literature review of 26 cases

Urology Annals, 2015
Primary lymphoma of the urinary bladder is exceedingly rare, representing 0.2% of all extranodal non-Hodgkin′s lymphoma. Although Matsuno et al. and others state the most common type is mucosa-associated lymphoid tissue (MALT) lymphoma, 20% of all the ...
W Greg Simpson, Armando Lopez, Paurush Babbar, Lynnetta Faith Payne   +3 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Molsidomine provides neuroprotection against vincristine-induced peripheral neurotoxicity through soluble guanylyl cyclase activation

Scientific Reports
Peripheral neurotoxicity is a dose-limiting adverse reaction of primary frontline chemotherapeutic agents, including vincristine. Neuropathy can be so disabling that patients drop out of potentially curative therapy, negatively impacting cancer prognosis.
Irina Utkina-Sosunova, Alessia Chiorazzi, Mariangels de Planell-Saguer, Hai Li, Cristina Meregalli, Eleonora Pozzi, Valentina Alda Carozzi, Annalisa Canta, Laura Monza, Paola Alberti, Giulia Fumagalli, Charles Karan, Yalda Moayedi, Serge Przedborski, Guido Cavaletti, Francesco Lotti   +15 more
doaj   +1 more source

Molecular mechanisms of apoptosis induction in murine lymphoma NK/Ly under chemotherapy in vivo

Біологічні студії, 2009
Peculiarities of the molecular mechanisms that participate in realization of cytotoxic action of anticancer drugs vincristine and doxorubicin towards cells of murine lymphoma NK/Ly during in vivo chemotherapy have been defined.
R. R. Panchuk, N. M. Boiko, R. S. Stoika
doaj   +1 more source