Results 21 to 30 of about 86,503 (159)

The Effect of Vincristine on Hypoxic, Apoptotic, and Autophagic Gene Expressions in Gastric Cancer Cells under Hypoxic Conditions [PDF]

Middle East Journal of Cancer, 2023
Background: Apoptosis and autophagy functions are known as death-inducing mechanisms. Vincristine (VCR) is a chemotherapeutic drug that binds with tubulin dimers and induces apoptosis in cancer cells. Furthermore, VCR protects cancer cells from apoptosis,
Meliha Irmak-Yazicioglu, Betül Ceylaner
doaj   +1 more source

Intratumoral recombinant human interferon alpha‐2a and vincristine combination therapy in canine transmissible venereal tumour

Veterinary Medicine and Science, 2018
Canine transmissible venereal tumour (CTVT) is a naturally occurring contagious neoplasm of dogs located mainly on the external genitalia of both sexes. The course of vincristine chemotherapy, the most effective and practical therapy, is affected by the ...
Halit Kanca, Gizem Tez, Kazim Bal, Dogukan Ozen, Eray Alcigir, Sevil Atalay Vural   +5 more
doaj   +1 more source

CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy

Molecular Oncology, 2020
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI‐anchored protein, was overexpressed in
Jie Sun, Dongju Feng, Huiyu Xi, Jiajing Luo, Zewei Zhou, Qinghuai Liu, Yun Chen, Qing Shao   +7 more
doaj   +1 more source

Hearing loss after exposure to vincristine and platinum-based chemotherapy among childhood cancer survivors [PDF]

, 2023
Background The role of vincristine as a contributing risk factor for hearing loss among childhood cancer survivors (CCS) treated with platinum-based chemotherapy has not been fully elucidated.
Strebel, Sven, Philippa Jörger, Seraina Uhlmann, Luzius Mader, Marc Ansari, Mader, Luzius, Uhlmann, Seraina, von der Weid, Nicolas, Ansari Djaberi, Marc Georges, Nicolas Waespe, Nicolas von der Weid, Claudia E. Kuehni, Waespe, Nicolas, Kuehni, Claudia E., Sven Strebel, Ansari, Marc, Jörger, Philippa   +16 more
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Effects of cromolyn sodium and honey on vincristine-induced neuropathic pain: An experimental study in mice [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. Chemotherapy-induced neuropathy is a significant side effect of anticancer drugs such as vincristine, leading to increased pain sensitivity and reduced quality of life. Investigations are required to reduce these adverse effects.
Moslem Najafi, Bohloul Habibi Asl, Hamideh Najafluy Mayan, Mina Islambulchilar   +3 more
doaj   +1 more source

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

, 2017
Background: Combination therapy is a key strategy for minimizing drug resistance, a common problem in cancer therapy. The microtubule-depolymerizing agent vincristine is widely used in the treatment of acute leukemia.
張雅玲;鄧哲明, Chao, Min-Wu;Lai, Mei-Jung;Liou, Jing-Ping;Chang, Ya-Ling;Wang, Jing-Chi;Pan, Shiow-Lin;Teng, Che-Ming   +1 more
core   +1 more source

Experience with Vincristine - Associated Neurotoxicity [PDF]

, 2014
Objectives: To evaluate the frequency and severity of occurrence of vincristine-associated neurotoxicity.Design: A retrospective case series studySetting: Burlingham Oncology Clinic, Nairobi.Subjects: Thirty-eight patients treated for various neoplasms ...
Othieno-Abinya, NA, Nyabola, LO
core   +1 more source

Ginger Constituent 6-Shogaol Attenuates Vincristine-Induced Activation of Mouse Gastroesophageal Vagal Afferent C-Fibers

Molecules, 2022
Chemotherapeutic agent-induced nausea and vomiting are the severe adverse effects that are induced by their stimulations on the peripheral and/or central emetic nerve pathways. Even though ginger has been widely used as an herbal medicine to treat emesis,
Mayur J. Patil, Yongming Huang, Mingwei Yu, Xinzhong Dong, Bradley J. Undem, Shaoyong Yu   +5 more
doaj   +1 more source

Vincristine-induced peripheral neurotoxicity: A prospective cohort

, 2019
Vincristine-induced peripheral neuropathy (VIPN) is a serious and pervasive problem, affecting 12–78% of pediatric patients, based on retrospective studies.
Shahrad Rod Rassekh (7816604), Mikaela K. Barker (7816580), Nassr Nama (4614352), Jennifer Raabe (7816595), Cheryl Sabarre (7816586), Veronica Solimano (7816589), Bruce Carleton (438967), Anne Rankin (7816592), Jill G. Zwicker (7816601), Celia Kwan (7816583), Colin J. Ross (7816598)   +10 more
core   +1 more source

Genetic Polymorphisms Associated with Vincristine Pharmacokinetics and Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology Patients

, 2022
SIMPLE SUMMARY: Vincristine is a type of chemotherapy that is often used in the treatment of children with cancer. The main side effect of vincristine is nerve damage. Patients experience symptoms such as tingling, pain or muscle weakness.
van den Berg, Marleen H., Chantrain, Christophe, van de Velde, Mirjam E., Cheng, Cheng, Evans, William E., Deqing Pei, Kaspers, Gertjan J.L., Cor van den Bos, van den Heuvel-Eibrink, Marry M., Marry M. van den Heuvel-Eibrink, Floor C. H. Abbink, Segers, Heidi, Pei, Deqing, Erik Bonten, William E. Evans, Marleen H. van den Berg, Christophe Chantrain, Gertjan J. L. Kaspers, Yang, Wenjian, Cheng Cheng, Inge M. van der Sluis, Jutte van der Werff ten Bosch, Kaspers, Gertjan J. L., Uittenboogaard, Aniek, van der Sluis, Inge M., Abbink, Floor C. H., Aniek Uittenboogaard, Willems, Leen, Wenjian Yang, van der Werff ten Bosch, Jutte, Heidi Segers, Mirjam E. van de Velde, ten Bosch, Jutte van der Werff, Abbink, Floor C.H., Leen Willems, Bonten, Erik, van den Bos, Cor   +36 more
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