Results 31 to 40 of about 71,670 (154)

Severe Vincristine-Induced Neuropathic Pain: A Case Report with Pharmacogenetic Analysis and Literature Review

Pharmacogenomics and Personalized Medicine, 2022
Ya-Hui Hu,1 Gui-Zhou Li,1,2 Jia-Yi Long,1,2 Qing-Yan Yang,1,2 Yong Zhang,1 Feng Chen,1 Yong-Ren Wang3 1Department of Pharmacy, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2School of Basic Medicine and Clinical ...
Hu YH, Li GZ, Long JY, Yang QY, Zhang Y, Chen F, Wang YR   +6 more
doaj  

Hyponatremia During Induction Therapy in Distinct Pediatric Oncological Cohorts: A Retrospective Study

Frontiers in Oncology, 2021
BackgroundHyponatremia is a well-known adverse event of repeated therapy with vincristine in oncological patients. However, to date, data in pediatric patients with malignant diseases other than acute lymphoblastic leukemia (ALL) are sparse or lacking ...
Christina Salvador, Robert Salvador, Peter Willeit, Peter Willeit, Christine Kuntner, Alexandra Haid, Thomas Müller, Gabriele Kropshofer, Roman Crazzolara   +8 more
doaj   +1 more source

Netazepide, an Antagonist of Cholecystokinin Type 2 Receptor, Prevents Vincristine-Induced Sensory Neuropathy in Mice

Pharmaceuticals
Among the vinca-alkaloid class, vincristine is a potent chemotherapeutic agent with significant neurotoxic effects and is employed to address a wide spectrum of cancer types.
Amandine Bernard, Mohamad Mroué, Sylvie Bourthoumieu, Malcolm Boyce, Laurence Richard, Franck Sturtz, Claire Demiot, Aurore Danigo   +7 more
doaj   +1 more source

Cannabis sativa L. Extract Alleviates Neuropathic Pain and Modulates CB1 and CB2 Receptor Expression in Rat

Biomolecules
Introduction: Cannabis sativa L. (CSL) extract has pain-relieving potential due to its cannabinoid content, so the effects of two CSL extracts on alleviating neuropathic pain were investigated in vivo.
Joanna Bartkowiak-Wieczorek, Agnieszka Bienert, Kamila Czora-Poczwardowska, Radosław Kujawski, Michał Szulc, Przemysław Mikołajczak, Anna-Maria Wizner, Małgorzata Jamka, Marcin Hołysz, Karolina Wielgus, Ryszard Słomski, Edyta Mądry   +11 more
doaj   +1 more source

Conventional-Vincristine Sulfate vs. Modified Protocol of Vincristine Sulfate and L-Asparaginase in Canine Transmissible Venereal Tumor

Frontiers in Veterinary Science, 2019
Background: Vincristine (VCR) is a mono-chemotherapy for canine transmissible venereal tumor (CTVT). L-asparaginase (LAP) is usually used in combination with other drugs. Previously, LAP-VCR protocol was applied for the CTVT-VCR-resistant cases. However,
Chanokchon Setthawongsin, Patharakrit Teewasutrakul, Sirikachorn Tangkawattana, Somporn Techangamsuwan, Anudep Rungsipipat   +4 more
doaj   +1 more source

Combination therapy with nisin, urolithin B, and vincristine exhibits synergistic antiproliferative and pro-apoptotic effects against human lymphoma cells: evidence from proteomics

Frontiers in Immunology
Lymphoma remains a significant global health burden, necessitating innovative, targeted therapeutic strategies. Nisin (N), a bacteriocin produced by Lactococcus lactis, has demonstrated antimicrobial and anticancer properties through membrane disruption ...
Ahmad K. Al-Khazaleh, Muhammad A. Alsherbiny, Muhammad A. Alsherbiny, Dennis Chang, Gerald Münch, Deep Jyoti Bhuyan, Deep Jyoti Bhuyan   +6 more
doaj   +1 more source

Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro

Lipids in Health and Disease, 2011
Previous studies showed that γ-linolenic acid (GLA, 18: 3 ω-6), arachidonic acid (AA, 20:4 ω -6), eicosapentaenoic acid (EPA, 20: 5 ω -3) and docosahexaenoic acid (DHA, 22:6 ω -3) have selective tumoricidal action.
Das Undurti N, Madhavi N
doaj   +1 more source

Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice

Acta Neuropathologica Communications
Vincristine is an essential chemotherapy agent administered for various pediatric cancers including acute lymphoblastic leukemia (ALL). While multi-agent chemotherapy for pediatric ALL is highly curative, with survival approaching 95%, it carries the ...
Jonas Yeung, Prisca Hsu, Jordan Mak, Ali Darbandi, Anne L. Wheeler, Rosanna Weksberg, Sharon L. Guger, Russell J. Schachar, Shinya Ito, Johann Hitzler, Brian J. Nieman   +10 more
doaj   +1 more source

The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo

Molecules, 2015
This study was aimed to investigate whether vitamin A deficiency could alter P-GP expression and function in tissues of rats and whether such effects affected the drug distribution in vivo of vitamin A-deficient rats.
Yubang Wang, Heng Qin, Chengxiang Zhang, Fei Huan, Ting Yan, Lulu Zhang   +5 more
doaj   +1 more source

A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation

Cancer Medicine, 2023
Background Patients with relapsed and refractory solid and central nervous system (CNS) tumors have poor outcomes and need novel therapeutic options. Vincristine, irinotecan, and temozolomide (VIT) is a common chemotherapy regimen in relapsed pediatric ...
Jonathan L. Metts, Matteo Trucco, Daniel A. Weiser, Patrick Thompson, Eric Sandler, Tiffany Smith, Jessica Crimella, Samer Sansil, Ram Thapa, Brooke L. Fridley, Nicholas Llosa, Thomas Badgett, Richard Gorlick, Damon Reed, Jonathan Gill   +14 more
doaj   +1 more source