Results 41 to 50 of about 86,503 (159)

Severe Vincristine-Induced Neuropathic Pain: A Case Report with Pharmacogenetic Analysis and Literature Review

Pharmacogenomics and Personalized Medicine, 2022
Ya-Hui Hu,1 Gui-Zhou Li,1,2 Jia-Yi Long,1,2 Qing-Yan Yang,1,2 Yong Zhang,1 Feng Chen,1 Yong-Ren Wang3 1Department of Pharmacy, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2School of Basic Medicine and Clinical ...
Hu YH, Li GZ, Long JY, Yang QY, Zhang Y, Chen F, Wang YR   +6 more
doaj  

Vincristine Treatment Protects Against Podocyte Damage in Focal Segmental Glomerulosclerosis

Kidney International Reports
Introduction: Focal segmental glomerulosclerosis (FSGS) is associated with podocyte damage resulting in cytoskeletal alterations leading to foot process effacement. Vincristine is a chemoprotective drug which alters cytoskeletal microtubules and has been
William J. Mason, Jennifer C. Chandler, Alice M. Gage, Gideon Pomeranz, Karen L. Price, Marilina Antonelou, Scott R. Henderson, Laura Perin, Stefano Da Sacco, Alan D. Salama, David A. Long, Ruth J. Pepper   +11 more
doaj   +1 more source

Vincristine sulfate liposomal injection for acute lymphoblastic leukemia

, 2013
Vincristine (VCR) is one of the most extensively used cytotoxic compounds in hemato-oncology. VCR is particularly important for the treatment of acute lymphoblastic leukemia (ALL), a disease that accounts for approximately one-third of all childhood ...
Smith, Amanda M., Smith AM, Moore, Andrew S., Soosay Raj, Trisha A., Soosay Raj TA, Moore AS   +5 more
core   +1 more source

Biomarkers of Chemotherapy-Induced Peripheral Neuropathy: Current Status and Future Directions

Frontiers in Pain Research, 2022
Chemotherapy induced peripheral neuropathy (CIPN) is an often severe and debilitating complication of multiple chemotherapeutic agents that can affect patients of all ages, across cancer diagnoses.
Rozalyn L. Rodwin, Namrah Z. Siddiq, Barbara E. Ehrlich, Barbara E. Ehrlich, Maryam B. Lustberg, Maryam B. Lustberg   +5 more
doaj   +1 more source

Vincristine Metabolism and the Role of CYP3A5

, 2007
Indiana University-Purdue University Indianapolis (IUPUI)Vincristine is metabolized by the cytochrome P450 3A subfamily of enzymes possibly including CYP3A5, a genetically polymorphic enzyme.
Dennison, Jennifer Bolin
core   +1 more source

Cannabis sativa L. Extract Alleviates Neuropathic Pain and Modulates CB1 and CB2 Receptor Expression in Rat

Biomolecules
Introduction: Cannabis sativa L. (CSL) extract has pain-relieving potential due to its cannabinoid content, so the effects of two CSL extracts on alleviating neuropathic pain were investigated in vivo.
Joanna Bartkowiak-Wieczorek, Agnieszka Bienert, Kamila Czora-Poczwardowska, Radosław Kujawski, Michał Szulc, Przemysław Mikołajczak, Anna-Maria Wizner, Małgorzata Jamka, Marcin Hołysz, Karolina Wielgus, Ryszard Słomski, Edyta Mądry   +11 more
doaj   +1 more source

Conventional-Vincristine Sulfate vs. Modified Protocol of Vincristine Sulfate and L-Asparaginase in Canine Transmissible Venereal Tumor

Frontiers in Veterinary Science, 2019
Background: Vincristine (VCR) is a mono-chemotherapy for canine transmissible venereal tumor (CTVT). L-asparaginase (LAP) is usually used in combination with other drugs. Previously, LAP-VCR protocol was applied for the CTVT-VCR-resistant cases. However,
Chanokchon Setthawongsin, Patharakrit Teewasutrakul, Sirikachorn Tangkawattana, Somporn Techangamsuwan, Anudep Rungsipipat   +4 more
doaj   +1 more source

Combination therapy with nisin, urolithin B, and vincristine exhibits synergistic antiproliferative and pro-apoptotic effects against human lymphoma cells: evidence from proteomics

Frontiers in Immunology
Lymphoma remains a significant global health burden, necessitating innovative, targeted therapeutic strategies. Nisin (N), a bacteriocin produced by Lactococcus lactis, has demonstrated antimicrobial and anticancer properties through membrane disruption ...
Ahmad K. Al-Khazaleh, Muhammad A. Alsherbiny, Muhammad A. Alsherbiny, Dennis Chang, Gerald Münch, Deep Jyoti Bhuyan, Deep Jyoti Bhuyan   +6 more
doaj   +1 more source

Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro

Lipids in Health and Disease, 2011
Previous studies showed that γ-linolenic acid (GLA, 18: 3 ω-6), arachidonic acid (AA, 20:4 ω -6), eicosapentaenoic acid (EPA, 20: 5 ω -3) and docosahexaenoic acid (DHA, 22:6 ω -3) have selective tumoricidal action.
Das Undurti N, Madhavi N
doaj   +1 more source

The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo

Molecules, 2015
This study was aimed to investigate whether vitamin A deficiency could alter P-GP expression and function in tissues of rats and whether such effects affected the drug distribution in vivo of vitamin A-deficient rats.
Yubang Wang, Heng Qin, Chengxiang Zhang, Fei Huan, Ting Yan, Lulu Zhang   +5 more
doaj   +1 more source