Results 41 to 50 of about 111,805 (253)

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Primary bladder lymphoma, diffuse large B-cell type: Case report and literature review of 26 cases

Urology Annals, 2015
Primary lymphoma of the urinary bladder is exceedingly rare, representing 0.2% of all extranodal non-Hodgkin′s lymphoma. Although Matsuno et al. and others state the most common type is mucosa-associated lymphoid tissue (MALT) lymphoma, 20% of all the ...
W Greg Simpson, Armando Lopez, Paurush Babbar, Lynnetta Faith Payne   +3 more
doaj   +1 more source

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]

, 2017
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G., Colotti, Gianni, Fazi, Francesco, Genovese, Ilaria, Ilari, Andrea   +4 more
core   +1 more source

Molsidomine provides neuroprotection against vincristine-induced peripheral neurotoxicity through soluble guanylyl cyclase activation

Scientific Reports
Peripheral neurotoxicity is a dose-limiting adverse reaction of primary frontline chemotherapeutic agents, including vincristine. Neuropathy can be so disabling that patients drop out of potentially curative therapy, negatively impacting cancer prognosis.
Irina Utkina-Sosunova, Alessia Chiorazzi, Mariangels de Planell-Saguer, Hai Li, Cristina Meregalli, Eleonora Pozzi, Valentina Alda Carozzi, Annalisa Canta, Laura Monza, Paola Alberti, Giulia Fumagalli, Charles Karan, Yalda Moayedi, Serge Przedborski, Guido Cavaletti, Francesco Lotti   +15 more
doaj   +1 more source

Molecular mechanisms of apoptosis induction in murine lymphoma NK/Ly under chemotherapy in vivo

Біологічні студії, 2009
Peculiarities of the molecular mechanisms that participate in realization of cytotoxic action of anticancer drugs vincristine and doxorubicin towards cells of murine lymphoma NK/Ly during in vivo chemotherapy have been defined.
R. R. Panchuk, N. M. Boiko, R. S. Stoika
doaj   +1 more source

Vincristine polyneuropathy in children with acute lymphoblastic leukemia: the association with the hereditary rs924607 polymorphism in the CEP72 gene

Alʹmanah Kliničeskoj Mediciny, 2023
Background: Vincristine polyneuropathy is a major neurotoxic complication of treatment for acute lymphoblastic leukemia in children. A close relationship between genetic variants in candidate genes associated with the vincristine neurotoxicity in various
Oksana V. Koryakina, Olga P. Kovtun, Grigory A. Tsaur, Elena V. Tsyganko, Larisa G. Fechina, Vladimir V. Bazarnyi   +5 more
doaj   +1 more source

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy [PDF]

Korean Journal of Anesthesiology, 2020
Background Studies investigating the correlation between spinal adenosine A1 receptors and vincristine-induced peripheral neuropathy (VIPN) are limited.
Kyungmi Kim, Wonyeong Jeong, In Gu Jun, Jong Yeon Park   +3 more
doaj   +1 more source

Chemoresistance induces enhanced adhesion and transendothelial penetration of neuroblastoma cells by down-regulating NCAM surface expression [PDF]

, 2006
Background Drug resistance to chemotherapy is often associated with increased malignancy in neuroblastoma (NB). One explanation for the link between resistance and malignancy might be that resistance facilitates cancer progression and invasion.
Blaheta, Roman A., Daher, Frederick H., Michaelis, Martin, Hasenberg, Christoph, Weich, Eva M., Jonas, Dietger, Kotchetkov, Rouslan, Doerr, Hans Wilhelm, Cinatl, Jindrich   +8 more
core   +1 more source

Vincristine Treatment Protects Against Podocyte Damage in Focal Segmental Glomerulosclerosis

Kidney International Reports
Introduction: Focal segmental glomerulosclerosis (FSGS) is associated with podocyte damage resulting in cytoskeletal alterations leading to foot process effacement. Vincristine is a chemoprotective drug which alters cytoskeletal microtubules and has been
William J. Mason, Jennifer C. Chandler, Alice M. Gage, Gideon Pomeranz, Karen L. Price, Marilina Antonelou, Scott R. Henderson, Laura Perin, Stefano Da Sacco, Alan D. Salama, David A. Long, Ruth J. Pepper   +11 more
doaj   +1 more source