Results 81 to 90 of about 1,258 (192)

ISOLATION OF VINDOLINE FROM CATHARANTHUS-ROSEUS BY SUPERCRITICAL FLUID EXTRACTION

, 1992
Vindoline was extracted from the leaves of Catharanthus roseus over the ranges of 35-70-degrees-C and 100-300 bar using supercritical carbon dioxide with and without the addition of 3 wt % ethanol as a cosolvent.
Lee, Huen, PARK, SW, LIU, JR, Hong, Won-Hi, KWAK, SS, SONG, KM   +5 more
core  

A Novel AP2/ERF Transcription Factor CR1 Regulates the Accumulation of Vindoline and Serpentine in Catharanthus roseus

Frontiers in Plant Science, 2017
As one type of the most important alkaloids in the world, terpenoid indole alkaloids (TIAs) show a wide range of pharmaceutical activities that are beneficial for clinical treatments.
Jiaqi Liu, Fangyuan Gao, Juansheng Ren, Xianjun Lu, Guangjun Ren, Rui Wang   +5 more
doaj   +1 more source

A Simplified Procedure for Indole Alkaloid Extraction from Catharanthus roseus Combined with a Semi-synthetic Production Process for Vinblastine

Molecules, 2007
Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola, Aarre Huhtikangas, Tuulikki Seppänen-Laakso, Into Laakso, Arvind Verma   +4 more
doaj   +1 more source

Total Synthesis of (−)- and ent-(+)-Vindoline

, 2016
Two exceptionally concise total syntheses of (−)- and ent-(+)-vindoline are detailed enlisting a diastereoselective tandem [4 + 2]/[3 + 2] cycloaddition of a 1,3,4-oxadiazole.
Dale L. Boger (1306542), Gregory I. Elliott (2531527), Juraj Velcicky (2201350), Younggi Choi (2531542), Michael M. Miller (1668040), Hayato Ishikawa (2134999)   +5 more
core   +1 more source

Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don

Molecules, 2013
Catharanthus roseus (L.) G. Don is a herbal plant traditionally used by local populations in India, South Africa, China and Malaysia to treat diabetes. The present study reports the in vitro antioxidant and antidiabetic activities of the major alkaloids ...
Won Fen Wong, Shiau-Chuen Cheah, Mohd Rais Mustafa, Mohammadjavad Paydar, Aditya Arya, Soon Huat Tiong, Chung Yeng Looi, Khalijah Awang, Hazrina Hazni   +8 more
doaj   +1 more source

Enhanced catharanthine and vindoline production in suspension cultures of by ultraviolet-B light-4

, 2011
Ted and harvested at indicated times. , Catharanthine and , vindoline accumulation was detected by HPLC as described in materials and methods. Values are represented as the means ± SD (n = 3).Copyright information:Taken from "Enhanced catharanthine and ...
Chelliah Jayabaskaran (92029), Shilpa Ramani (74710)   +1 more
core   +1 more source

Laccase-catalyzed coupling of catharanthine and vindoline : an efficient approach to the bisindole alkaloid anhydrovinblastine

, 2009
The efficient enzyme-catalyzed coupling of the indolic alkaloids catharanthine and vindoline was carried out by exploiting the oxidoreductases laccases and atmospheric oxygen.
C. Chirivì, D. Passarella, S. Riva, B. Danieli, S. Nicotra, F. Sagui, G. Fontana   +6 more
core   +1 more source

Radiolytically degraded sodium alginate enhances plant growth, physiological activities and alkaloids production in Catharanthus roseus L.

Journal of Radiation Research and Applied Sciences, 2015
Catharanthus roseus (L.) G. Don (Family Apocynaceae) is a medicinal plant that produces indole alkaloids used in cancer chemotherapy. The anticancerous alkaloids, viz. vinblastine and vincristine, are mainly present in the leaves of C. roseus.
M. Naeem, Tariq Aftab, Abid A. Ansari, Mohd Idrees, Akbar Ali, M. Masroor A. Khan, Moin Uddin, Lalit Varshney   +7 more
doaj   +1 more source

Total Synthesis and Evaluation of Vinblastine Analogues Containing Systematic Deep-Seated Modifications in the Vindoline Subunit Ring System: Core Redesign

, 2016
The total synthesis of a systematic series of vinblastine analogues that contain deep-seated structural modifications to the core ring system of the lower vindoline subunit is described. Complementary to the vindoline 6,5 DE ring system, compounds with 5,
Annie Tam (1508698), Dale L. Boger (1306542), Kristin D. Schleicher (1999369), Daisuke Kato (1827106), Katharine K. Duncan (1897090), Yoshikazu Sasaki (1809736)   +5 more
core   +1 more source

Molecular Docking of Isolated Alkaloids for Possible α-Glucosidase Inhibition

Biomolecules, 2019
Diabetes mellitus, one of the most common endocrine-metabolic disorders, has caused significant morbidity and mortality worldwide. To avoid sugar digestion and postprandial hyperglycemia, it is necessary to inhibit α-glucosidase, a digestive enzyme ...
Noor Rahman, Ijaz Muhammad, Gul-E-Nayab, Haroon Khan, Michael Aschner, Rosanna Filosa, Maria Daglia   +6 more
doaj   +1 more source