Results 61 to 70 of about 1,258 (192)

Evaluation of Metabolites and Biological Activities of Areca Nut (Areca catechu L.) Under Different pH: Untargeted Mass Spectrometry–Based Metabolomics Approach

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Chewing areca nuts (ANs) produces a mild sense of excitement and happiness, particularly under alkaline conditions. To identify the substances responsible for these effects, we conducted a nontargeted metabolomics analysis comparing AN metabolites at different pH levels. Subsequently, AN’s active components were determined, and the in vitro antioxidant
Jing Zhang, Jiahui Dai, Shiping Wang, Kai Rui, Wenting Dai, Xiaoning Kang, Jianbang Ji, Weizhong Wang, Piyush Kashyap   +8 more
wiley   +1 more source

Improvement of Vindoline Production in a <i>Catharanthus roseus callus</i> Line

, 2011
The influence of polyploidity on the accumulation of vindoline in Catharanthus roseus callus cultures was investigated. The callus line (T1) was induced from a tetraploid leaf.
Bei Bei Xiang, Wen Juan Wang, Yan Ling Bai, Yong Wang, Ye Rong Zhu   +4 more
core   +1 more source

Triarylaminium Radical Cation Promoted Coupling of Catharanthine with Vindoline: Diastereospecific Synthesis of Anhydrovinblastine and Reaction Scope

, 2019
A new triarylaminium radical cation promoted coupling of catharanthine with vindoline is disclosed, enlisting tris­(4-bromophenyl)­aminium hexachlororantimonate (BAHA, 1.1 equiv) in aqueous 0.05 N HCl/trifluoroethanol (1–10:1) at room temperature (25 °C),
Dale L. Boger (1306542), Byron A. Boon (3944282), Dale L. Boger, Byron A. Boon   +3 more
core   +3 more sources

Terpene Moiety Enhancement by Overexpression of Geranyl(geranyl) Diphosphate Synthase and Geraniol Synthase Elevates Monomeric and Dimeric Monoterpene Indole Alkaloids in Transgenic Catharanthus roseus

Frontiers in Plant Science, 2018
Catharanthus roseus is the sole source of two of the most important anticancer monoterpene indole alkaloids (MIAs), vinblastine and vincristine and their precursors, vindoline and catharanthine.
Sarma R. Kumar, H. B. Shilpashree, Dinesh A. Nagegowda   +2 more
doaj   +1 more source

Genome‐based discovery of pachysiphine synthases in Tabernaemontana elegans

The Plant Journal, Volume 120, Issue 5, Page 1880-1900, December 2024.
Significance Statement While pachysiphine is a monoterpene indole alkaloid of high interest and the precursor of an anti‐Alzheimer compound, its biosynthesis involving the epoxidation of tabersonine remains uncharacterized. By sequencing and assembling the genome of Tabernaemontana elegans, we identified two P450s exhibiting a pachysiphine synthase ...
Enzo Lezin, Mickael Durand, Caroline Birer Williams, Ana Luisa Lopez Vazquez, Thomas Perrot, Nicolas Gautron, Julien Pétrignet, Clément Cuello, Hans J. Jansen, Florent Magot, Sarah Szwarc, Pierre Le Pogam, Mehdi A. Beniddir, Konstantinos Koudounas, Audrey Oudin, Benoit St‐Pierre, Nathalie Giglioli‐Guivarc'h, Chao Sun, Nicolas Papon, Michael Krogh Jensen, Ron P. Dirks, Sarah E. O'Connor, Sébastien Besseau, Vincent Courdavault   +23 more
wiley   +1 more source

Role of Polyethylene Glycol in production of Anticancer Alkaloids Vincristine, Vinblastine, and Vindoline in Catharanthus roseus via Callus Culture

Kufa Journal for Agricultural Sciences
Periwinkle Cathranthus roseus  is an ornamental plant that produces over 200 alkaloids, including vincristine, vinblastine, and vindoline, which are used to treat various types of cancer.
Zainab Abdulwahid, Abdulminam Hussien Ali Al-Musawi, Abdullah Hamad Lafta   +2 more
doaj   +1 more source

Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis

The Plant Journal, Volume 120, Issue 6, Page 2770-2783, December 2024.
SUMMARY Cytochrome P450 monooxygenases (CYPs) are well known for their ability to catalyze diverse oxidation reactions, playing a significant role in the biosynthesis of various natural products. In the realm of monoterpenoid indole alkaloids (MIAs), one of the largest groups of alkaloids in nature, CYPs are integral to reactions such as hydroxylation,
Zhan Mai, Kyunghee Kim, Matthew Bailey Richardson, Daniel André Ramey Deschênes, Jorge Jonathan Oswaldo Garza‐Garcia, Mohammadamin Shahsavarani, Jacob Owen Perley, Destiny Ichechi Njoku, Ghislain Deslongchamps, Vincenzo De Luca, Yang Qu   +10 more
wiley   +1 more source

Molecular docking and pharmacogenomics of Vinca alkaloids and their monomeric precursors, vindoline and catharanthine

, 2011
International audienceVinblastine and vincristine are dimeric indole alkaloids derived from (formerly: ). Their monomeric precursor molecules are vindoline and catharanthine.
Thomas Efferth, Konkimalla, Badireenath, Zu, Yuangang, Efferth, Thomas, Rebacz, Blanka, Krämer, Alwin, Fu, Yujie, Peter K. Plinkert, Gertsch, Jürg, Blanka Rebacz, Jürg Gertsch, Alwin Krämer, Sertel, Serkan, Yuangang Zu, Badireenath Konkimalla, Serkan Sertel, Plinkert, Peter K., Yujie Fu   +17 more
core   +1 more source

Transcriptome analysis of Catharanthus roseus for gene discovery and expression profiling. [PDF]

PLoS ONE, 2014
The medicinal plant, Catharanthus roseus, accumulates wide range of terpenoid indole alkaloids, which are well documented therapeutic agents. In this study, deep transcriptome sequencing of C.
Mohit Verma, Rajesh Ghangal, Raghvendra Sharma, Alok K Sinha, Mukesh Jain   +4 more
doaj   +1 more source

The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia

Pediatric Blood &Cancer, Volume 71, Issue 11, November 2024.
Abstract An attractive flower from the island of Madagascar has in part saved the lives of thousands of children with acute lymphoblastic leukemia (ALL). Random mutations and alterations to the genome led to the evolution of genes encoding enzymes, which would provide the periwinkle flower an arsenal of secondary metabolites to survive within the ...
Jeffrey W. Taub, Steven A. Buck, Ana C. Xavier, Holly Edwards, Larry H. Matherly, Yubin Ge   +5 more
wiley   +1 more source