Results 61 to 70 of about 1,375 (189)

Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Indole Alkaloids Isolated from Catharanthus roseus (L.) G. Don Cultivated Conventionally and Derived from In vitro Cultures

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2016
Catharanthus roseus (periwinkle) is a medicinal plant commonly known for its wide biological activity. In many countries different parts of this plant are used for the treatment of diabetes, hypertension and for menstrual regulation.
Aneta WESOŁOWSKA, Janusz WILAS, Monika GRZESZCZUK, Danuta KULPA   +3 more
doaj   +1 more source

Evaluation of Metabolites and Biological Activities of Areca Nut (Areca catechu L.) Under Different pH: Untargeted Mass Spectrometry–Based Metabolomics Approach

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Chewing areca nuts (ANs) produces a mild sense of excitement and happiness, particularly under alkaline conditions. To identify the substances responsible for these effects, we conducted a nontargeted metabolomics analysis comparing AN metabolites at different pH levels. Subsequently, AN’s active components were determined, and the in vitro antioxidant
Jing Zhang, Jiahui Dai, Shiping Wang, Kai Rui, Wenting Dai, Xiaoning Kang, Jianbang Ji, Weizhong Wang, Piyush Kashyap   +8 more
wiley   +1 more source

Improvement of Vindoline Production in a <i>Catharanthus roseus callus</i> Line

, 2011
The influence of polyploidity on the accumulation of vindoline in Catharanthus roseus callus cultures was investigated. The callus line (T1) was induced from a tetraploid leaf.
Bei Bei Xiang, Wen Juan Wang, Yan Ling Bai, Yong Wang, Ye Rong Zhu   +4 more
core   +1 more source

Genome‐based discovery of pachysiphine synthases in Tabernaemontana elegans

The Plant Journal, Volume 120, Issue 5, Page 1880-1900, December 2024.
Significance Statement While pachysiphine is a monoterpene indole alkaloid of high interest and the precursor of an anti‐Alzheimer compound, its biosynthesis involving the epoxidation of tabersonine remains uncharacterized. By sequencing and assembling the genome of Tabernaemontana elegans, we identified two P450s exhibiting a pachysiphine synthase ...
Enzo Lezin, Mickael Durand, Caroline Birer Williams, Ana Luisa Lopez Vazquez, Thomas Perrot, Nicolas Gautron, Julien Pétrignet, Clément Cuello, Hans J. Jansen, Florent Magot, Sarah Szwarc, Pierre Le Pogam, Mehdi A. Beniddir, Konstantinos Koudounas, Audrey Oudin, Benoit St‐Pierre, Nathalie Giglioli‐Guivarc'h, Chao Sun, Nicolas Papon, Michael Krogh Jensen, Ron P. Dirks, Sarah E. O'Connor, Sébastien Besseau, Vincent Courdavault   +23 more
wiley   +1 more source

Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis

The Plant Journal, Volume 120, Issue 6, Page 2770-2783, December 2024.
SUMMARY Cytochrome P450 monooxygenases (CYPs) are well known for their ability to catalyze diverse oxidation reactions, playing a significant role in the biosynthesis of various natural products. In the realm of monoterpenoid indole alkaloids (MIAs), one of the largest groups of alkaloids in nature, CYPs are integral to reactions such as hydroxylation,
Zhan Mai, Kyunghee Kim, Matthew Bailey Richardson, Daniel André Ramey Deschênes, Jorge Jonathan Oswaldo Garza‐Garcia, Mohammadamin Shahsavarani, Jacob Owen Perley, Destiny Ichechi Njoku, Ghislain Deslongchamps, Vincenzo De Luca, Yang Qu   +10 more
wiley   +1 more source

Role of Polyethylene Glycol in production of Anticancer Alkaloids Vincristine, Vinblastine, and Vindoline in Catharanthus roseus via Callus Culture

Kufa Journal for Agricultural Sciences
Periwinkle Cathranthus roseus  is an ornamental plant that produces over 200 alkaloids, including vincristine, vinblastine, and vindoline, which are used to treat various types of cancer.
Zainab Abdulwahid, Abdulminam Hussien Ali Al-Musawi, Abdullah Hamad Lafta   +2 more
doaj   +1 more source

Terpene Moiety Enhancement by Overexpression of Geranyl(geranyl) Diphosphate Synthase and Geraniol Synthase Elevates Monomeric and Dimeric Monoterpene Indole Alkaloids in Transgenic Catharanthus roseus

Frontiers in Plant Science, 2018
Catharanthus roseus is the sole source of two of the most important anticancer monoterpene indole alkaloids (MIAs), vinblastine and vincristine and their precursors, vindoline and catharanthine.
Sarma R. Kumar, H. B. Shilpashree, Dinesh A. Nagegowda   +2 more
doaj   +1 more source

Phytochemicals Derived from Catharanthus roseus and Their Health Benefits

Technologies, 2020
Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant ...
Hong Ngoc Thuy Pham, Quan Van Vuong, Michael C. Bowyer, Christopher J. Scarlett   +3 more
doaj   +1 more source

The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia

Pediatric Blood &Cancer, Volume 71, Issue 11, November 2024.
Abstract An attractive flower from the island of Madagascar has in part saved the lives of thousands of children with acute lymphoblastic leukemia (ALL). Random mutations and alterations to the genome led to the evolution of genes encoding enzymes, which would provide the periwinkle flower an arsenal of secondary metabolites to survive within the ...
Jeffrey W. Taub, Steven A. Buck, Ana C. Xavier, Holly Edwards, Larry H. Matherly, Yubin Ge   +5 more
wiley   +1 more source

Mass spectral evidence of the occurrence of vindoline in heterotrophic cultures of Catharanthus roseus cells

, 1989
Vindoline concentrations in the leaves of 70 Catharanthus Roseus of 3 cultivars were analyzed by HPLC, and 3 plants were selected for starting callus cultures on different media.
Lounasmaa, Mauri, Naaranlahti, Toivo, Toivonen, Leena, Huhtikangas, Aarre, Kauppinen, Veli, Lapinjoki, Seppo, Kurtén, Ulrika   +6 more
core   +1 more source