Results 61 to 70 of about 2,154 (205)

Inhibition of Gastric H, K-ATPase Activity by Compounds from Medicinal Plants

Natural Product Communications, 2011
H + , K + -ATPase enzyme is a therapeutic target for the treatment of gastric disturbances. Several medicinal plants and isolated compounds inhibit the acid gastric secretion through interaction with the proton pump.
Cristina Setim Freitas, Cristiane Hatsuko Baggio, Bárbara Mayer, Ana Cristina dos Santos, André Twardowschy, Cid Aimbiré de Moraes Santos, Maria Consuelo Andrade Marques   +6 more
doaj   +1 more source

Development of efficient catharanthus roseus regeneration and transformation system using agrobacterium tumefaciens and hypocotyls as explants

BMC Biotechnology, 2012
Background As a valuable medicinal plant, Madagascar periwinkle (Catharanthus roseus) produces many terpenoid indole alkaloids (TIAs), such as vindoline, ajamlicine, serpentine, catharanthine, vinblastine and vincristine et al. Some of them are important
Wang Quan, Xing Shihai, Pan Qifang, Yuan Fang, Zhao Jingya, Tian Yuesheng, Chen Yu, Wang Guofeng, Tang Kexuan   +8 more
doaj   +1 more source

Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats [PDF]

, 2015
Syzygium polyanthum (S. polyanthum), a plant belonging to Myrtaceae, is widely used in Indonesian and Malaysian cuisines. Diabetic patients in Indonesia also commonly use it as a traditional medicine. Hence, this study was conducted to investigate the
Ahmad, Mariam, Asmawi, Mohd Zaini, Widyawati, Tri, Yusoff, Nor Adlin   +3 more
core   +2 more sources

Cell‐type‐aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus

New Phytologist, Volume 245, Issue 1, Page 347-362, January 2025.
Summary In plants, the biosynthetic pathways of some specialized metabolites are partitioned into specialized or rare cell types, as exemplified by the monoterpenoid indole alkaloid (MIA) pathway of Catharanthus roseus (Madagascar Periwinkle), the source of the anticancer compounds vinblastine and vincristine. In the leaf, the C.
Chenxin Li, Maite Colinas, Joshua C. Wood, Brieanne Vaillancourt, John P. Hamilton, Sophia L. Jones, Lorenzo Caputi, Sarah E. O'Connor, C. Robin Buell   +8 more
wiley   +1 more source

Evaluation of Metabolites and Biological Activities of Areca Nut (Areca catechu L.) Under Different pH: Untargeted Mass Spectrometry–Based Metabolomics Approach

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Chewing areca nuts (ANs) produces a mild sense of excitement and happiness, particularly under alkaline conditions. To identify the substances responsible for these effects, we conducted a nontargeted metabolomics analysis comparing AN metabolites at different pH levels. Subsequently, AN’s active components were determined, and the in vitro antioxidant
Jing Zhang, Jiahui Dai, Shiping Wang, Kai Rui, Wenting Dai, Xiaoning Kang, Jianbang Ji, Weizhong Wang, Piyush Kashyap   +8 more
wiley   +1 more source

Genome‐based discovery of pachysiphine synthases in Tabernaemontana elegans

The Plant Journal, Volume 120, Issue 5, Page 1880-1900, December 2024.
Significance Statement While pachysiphine is a monoterpene indole alkaloid of high interest and the precursor of an anti‐Alzheimer compound, its biosynthesis involving the epoxidation of tabersonine remains uncharacterized. By sequencing and assembling the genome of Tabernaemontana elegans, we identified two P450s exhibiting a pachysiphine synthase ...
Enzo Lezin, Mickael Durand, Caroline Birer Williams, Ana Luisa Lopez Vazquez, Thomas Perrot, Nicolas Gautron, Julien Pétrignet, Clément Cuello, Hans J. Jansen, Florent Magot, Sarah Szwarc, Pierre Le Pogam, Mehdi A. Beniddir, Konstantinos Koudounas, Audrey Oudin, Benoit St‐Pierre, Nathalie Giglioli‐Guivarc'h, Chao Sun, Nicolas Papon, Michael Krogh Jensen, Ron P. Dirks, Sarah E. O'Connor, Sébastien Besseau, Vincent Courdavault   +23 more
wiley   +1 more source

Phytochemicals Derived from Catharanthus roseus and Their Health Benefits

Technologies, 2020
Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant ...
Hong Ngoc Thuy Pham, Quan Van Vuong, Michael C. Bowyer, Christopher J. Scarlett   +3 more
doaj   +1 more source

Exploiting members of the BAHD acyltransferase family to synthesize multiple hydroxycinnamate and benzoate conjugates in yeast [PDF]

, 2013
BACKGROUND: BAHD acyltransferases, named after the first four biochemically characterized enzymes of the group, are plant-specific enzymes that catalyze the transfer of coenzyme A-activated donors onto various acceptor molecules. They are responsible for
A Del Olmo, A Eudes, A Eudes, A Eudes, A Eudes, A Moglia, A Reider Apel, A Yamamoto, Aindrila Mukhopadhyay, AV Qualley, Aymerick Eudes, B Jayaprakasam, B Kim, BE Yingyongnarongkul, BG Kim, C Anselmi, C Chen, C Landmann, CB Jendresen, CC Ho, CG Wilkerson, CM Ma, CM Ma, D Hadjipavlou-Litina, D Juminaga, David S. Robinson, DK Kosma, Dominique Loqué, EA Winzeler, Edward E. K. Baidoo, F Jansen, G Bokinsky, G Fodor, G Grynkiewicz, G Murtaza, G Zhao, GD Kim, George Wang, GW Schmidt, H Mo, H Sun, Henrik V. Scheller, HR El-Seedi, IA Kim, J Boatright, J Jiang, J Luo, J Nielsen, J Palazón, J Sheng, J Sun, Jay D. Keasling, JC D’Auria, JC D’Auria, JD Guzman, JD Keasling, Joshua L. Heazlewood, K Burhenne, KK Hong, KO Evans, Lucien Roux, M Kikugawa, M Sullivan, Maxence Mouille, MF Tolba, MN Cha, N Dudareva, P Liu, P Zhang, PV van Summeren-Wesenhagen, R Niggeweg, RA Heins, S Fixon-Owoo, S Ohta, S Singh, Samuel Deutsch, SC Chou, SE Bloch, SK Kim, SM Richardson, TB Adams, TS Ham, Tsan-Yu Chiu, Veronica T. Benites, W Runguphan, Y Kimura, Y Zhuang, Yi-Lin Tsai, Z Li   +88 more
core   +2 more sources

Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis

The Plant Journal, Volume 120, Issue 6, Page 2770-2783, December 2024.
SUMMARY Cytochrome P450 monooxygenases (CYPs) are well known for their ability to catalyze diverse oxidation reactions, playing a significant role in the biosynthesis of various natural products. In the realm of monoterpenoid indole alkaloids (MIAs), one of the largest groups of alkaloids in nature, CYPs are integral to reactions such as hydroxylation,
Zhan Mai, Kyunghee Kim, Matthew Bailey Richardson, Daniel André Ramey Deschênes, Jorge Jonathan Oswaldo Garza‐Garcia, Mohammadamin Shahsavarani, Jacob Owen Perley, Destiny Ichechi Njoku, Ghislain Deslongchamps, Vincenzo De Luca, Yang Qu   +10 more
wiley   +1 more source

Terpene Moiety Enhancement by Overexpression of Geranyl(geranyl) Diphosphate Synthase and Geraniol Synthase Elevates Monomeric and Dimeric Monoterpene Indole Alkaloids in Transgenic Catharanthus roseus

Frontiers in Plant Science, 2018
Catharanthus roseus is the sole source of two of the most important anticancer monoterpene indole alkaloids (MIAs), vinblastine and vincristine and their precursors, vindoline and catharanthine.
Sarma R. Kumar, H. B. Shilpashree, Dinesh A. Nagegowda   +2 more
doaj   +1 more source