Results 51 to 60 of about 1,375 (189)

Stereochemical insights into sarpagan and akuammiline alkaloid biosynthesis

New Phytologist, Volume 247, Issue 3, Page 1335-1351, August 2025.
Summary Sarpagan and akuammiline monoterpenoid indole alkaloids (MIAs) are a class of bioactive plant‐derived compounds with significant pharmaceutical potential. These alkaloids are formed through oxidative cyclization of geissoschizine, catalyzed by homologous cytochrome P450 monooxygenases (CYP) known as sarpagan bridge enzymes (SBEs) and rhazimal ...
Scott Galeung Alexander Mann, Melina Paz‐Galeano, Mohammadamin Shahsavarani, Jacob Owen Perley, Jun Guo, Jorge Jonathan Oswaldo Garza‐Garcia, Yang Qu   +6 more
wiley   +1 more source

Synthesis of C-15 Vindoline Analogues by Palladium-Catalyzed Cross-Coupling Reactions

, 2016
Described are general protocols for the rapid construction of various C-15-substituted analogues of vindoline using palladium-catalyzed cross-coupling reactions.
Peter D. Johnson (1655887), Viresh H. Rawal (1323897), Jeong-Hun Sohn (249446)   +2 more
core   +1 more source

Novel Biocatalysts from Specialized Metabolism

Angewandte Chemie, Volume 136, Issue 4, January 22, 2024.
Enzymes are increasingly valuable as biocatalysts in synthetic chemistry. Many novel biocatalysts have emerged from the study of secondary metabolism, where rare and unusual reactions take place. In this review, we explore biocatalysts that address various synthetic challenges, including cyclization, C−H functionalization, and cross‐coupling, among ...
Hajo Kries, Felix Trottmann, Christian Hertweck   +2 more
wiley   +2 more sources

Effect of Aspergillus flavus Fungal Elicitor on the Production of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells

Molecules, 2018
This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by
Chuxin Liang, Chang Chen, Pengfei Zhou, Lv Xu, Jianhua Zhu, Jincai Liang, Jiachen Zi, Rongmin Yu   +7 more
doaj   +1 more source

The Potential of Indole Alkaloids in Bone Health and Osteoporosis Management

Applied Sciences
Indole alkaloids, a class of plant-derived nitrogen-containing compounds, have emerged as promising candidates for osteoporosis treatment. Their favorable biocompatibility profile demonstrated efficacy in preclinical models, and low reported toxicity ...
Anna Caruso, Virginia Caira, Hussein El-Kashef, Carmela Saturnino   +3 more
doaj   +1 more source

Inhibition of Gastric H, K-ATPase Activity by Compounds from Medicinal Plants

Natural Product Communications, 2011
H + , K + -ATPase enzyme is a therapeutic target for the treatment of gastric disturbances. Several medicinal plants and isolated compounds inhibit the acid gastric secretion through interaction with the proton pump.
Cristina Setim Freitas, Cristiane Hatsuko Baggio, Bárbara Mayer, Ana Cristina dos Santos, André Twardowschy, Cid Aimbiré de Moraes Santos, Maria Consuelo Andrade Marques   +6 more
doaj   +1 more source

Exploring the Mechanism of Action and Potential Targets of Saorilao‐4 Decoction in the Treatment of Pulmonary Fibrosis in Rats by Metabolomics

Food Science &Nutrition, Volume 13, Issue 2, February 2025.
Saorilao‐4 decoction (SRL), a Mongolian prescription, has shown therapeutic effects on pulmonary fibrosis (PF) in a rat model. Seventy‐one metabolic components, including sphingolipids and fatty acids, were identified in relation to PF progression. SRL influenced 59 metabolic components, particularly improving the metabolism of hexadecanoic acid and ...
Jiali Liu, Xinni Song, Xinyue Fu, Shufang Niu, Hong Chang, Songli Shi, Meiqing Yang, Peng Wang, Wanfu Bai   +8 more
wiley   +1 more source

Development of efficient catharanthus roseus regeneration and transformation system using agrobacterium tumefaciens and hypocotyls as explants

BMC Biotechnology, 2012
Background As a valuable medicinal plant, Madagascar periwinkle (Catharanthus roseus) produces many terpenoid indole alkaloids (TIAs), such as vindoline, ajamlicine, serpentine, catharanthine, vinblastine and vincristine et al. Some of them are important
Wang Quan, Xing Shihai, Pan Qifang, Yuan Fang, Zhao Jingya, Tian Yuesheng, Chen Yu, Wang Guofeng, Tang Kexuan   +8 more
doaj   +1 more source

Cell‐type‐aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus

New Phytologist, Volume 245, Issue 1, Page 347-362, January 2025.
Summary In plants, the biosynthetic pathways of some specialized metabolites are partitioned into specialized or rare cell types, as exemplified by the monoterpenoid indole alkaloid (MIA) pathway of Catharanthus roseus (Madagascar Periwinkle), the source of the anticancer compounds vinblastine and vincristine. In the leaf, the C.
Chenxin Li, Maite Colinas, Joshua C. Wood, Brieanne Vaillancourt, John P. Hamilton, Sophia L. Jones, Lorenzo Caputi, Sarah E. O'Connor, C. Robin Buell   +8 more
wiley   +1 more source

ISOLATION OF VINDOLINE FROM CATHARANTHUS-ROSEUS BY SUPERCRITICAL FLUID EXTRACTION

, 1992
Vindoline was extracted from the leaves of Catharanthus roseus over the ranges of 35-70-degrees-C and 100-300 bar using supercritical carbon dioxide with and without the addition of 3 wt % ethanol as a cosolvent.
Lee, Huen, PARK, SW, LIU, JR, Hong, Won-Hi, KWAK, SS, SONG, KM   +5 more
core   +1 more source