Results 51 to 60 of about 2,154 (205)
Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]
, 2022 Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko +7 more
core +2 more sources
Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals
Advanced Functional Materials, Volume 36, Issue 16, 23 February 2026.This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee +4 more
wiley +1 more source
Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)
Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni +5 more
wiley +1 more source
Stereochemical insights into sarpagan and akuammiline alkaloid biosynthesis
New Phytologist, Volume 247, Issue 3, Page 1335-1351, August 2025.Summary Sarpagan and akuammiline monoterpenoid indole alkaloids (MIAs) are a class of bioactive plant‐derived compounds with significant pharmaceutical potential. These alkaloids are formed through oxidative cyclization of geissoschizine, catalyzed by homologous cytochrome P450 monooxygenases (CYP) known as sarpagan bridge enzymes (SBEs) and rhazimal ...
Scott Galeung Alexander Mann +6 more
wiley +1 more source
Novel Biocatalysts from Specialized Metabolism
Angewandte Chemie, Volume 136, Issue 4, January 22, 2024.Enzymes are increasingly valuable as biocatalysts in synthetic chemistry. Many novel biocatalysts have emerged from the study of secondary metabolism, where rare and unusual reactions take place. In this review, we explore biocatalysts that address various synthetic challenges, including cyclization, C−H functionalization, and cross‐coupling, among ...
Hajo Kries +2 more
wiley +2 more sources
Journal of Plant Interactions, 2017 Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu +4 more
doaj +1 more source
Molecules, 2018 This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by
Chuxin Liang +7 more
doaj +1 more source
Cell type matters : competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]
, 2023 Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko +7 more
core +1 more source
Food Science &Nutrition, Volume 13, Issue 2, February 2025.Saorilao‐4 decoction (SRL), a Mongolian prescription, has shown therapeutic effects on pulmonary fibrosis (PF) in a rat model. Seventy‐one metabolic components, including sphingolipids and fatty acids, were identified in relation to PF progression. SRL influenced 59 metabolic components, particularly improving the metabolism of hexadecanoic acid and ...
Jiali Liu +8 more
wiley +1 more source
The Potential of Indole Alkaloids in Bone Health and Osteoporosis Management
Applied SciencesIndole alkaloids, a class of plant-derived nitrogen-containing compounds, have emerged as promising candidates for osteoporosis treatment. Their favorable biocompatibility profile demonstrated efficacy in preclinical models, and low reported toxicity ...
Anna Caruso +3 more
doaj +1 more source