Results 41 to 50 of about 1,727 (188)

Unveiling the Chemistry and Synthetic Potential of Catalytic Cycloaddition Reaction of Allenes: A Review

Molecules, 2023
Allenes with two carbon–carbon double bonds belong to a unique class of unsaturated hydrocarbons. The central carbon atom of allene is sp hybridized and forms two σ-bonds and two π-bonds with two terminal sp2 hybridized carbon atoms.
Sana Sikandar, Ameer Fawad Zahoor, Abdul Ghaffar, Muhammad Naveed Anjum, Razia Noreen, Ali Irfan, Bushra Munir, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +8 more
doaj   +1 more source

Evaluation of the impact of vindoline, an active components of Catharanthus roseus, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs

PLoS ONE, 2023
The objection of this study was to investigate the effects of vindoline(VDL) on the cytochrome P450 (CYP 450) isoforms (CYP1A2, 2B, 2C11, 2D1 and 3A) in rats. Firstly, the rats were randomly divided into VDL pretreatment group and blank group, each group
Yuqian Zhang, Haiying Niu, Jian Liu, Wei-wei Xie, Yiran Jin, Zhiqing Zhang   +5 more
semanticscholar   +1 more source

Spatial transcriptomics drives a new era in plant research

The Plant Journal, Volume 116, Issue 6, Page 1571-1581, December 2023., 2023
SUMMARY The plant community lags far behind the animal and human fields concerning the application of single‐cell methodologies. This is primarily due to the challenges associated with plant tissue dissection and the limitations of the available technologies.
Ruilian Yin, Keke Xia, Xun Xu
wiley   +1 more source

Bioproduction of monoterpene indole alkaloids in a single cell factory

Engineering Microbiology, 2022
The de novo biosynthesis of vindoline and catharanthine, the direct precursors used for industrial production of the anti-cancer drug vinblastine, has been achieved in the yeast cell factory.
Jianping Huang, Shengxiong Huang
doaj   +1 more source

Genome-wide identification and expression analysis of TCP family genes in Catharanthus roseus

Frontiers in Plant Science, 2023
IntroductionThe anti-tumor vindoline and catharanthine alkaloids are naturally existed in Catharanthus roseus (C. roseus), an ornamental plant in many tropical countries.
Juan Hao, Juan Hao, Lijun Zheng, Lijun Zheng, Yidie Han, Yidie Han, Hongshan Zhang, Hongshan Zhang, Hongshan Zhang, Kailin Hou, Kailin Hou, Xueshuang Liang, Xueshuang Liang, Cheng Chen, Zhijing Wang, Jiayi Qian, Jiayi Qian, Zhihao Lin, Zhihao Lin, Zitong Wang, Houqing Zeng, Houqing Zeng, Chenjia Shen, Chenjia Shen, Chenjia Shen   +24 more
doaj   +1 more source

Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]

PeerJ, 2021
Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Chun Yao Li, Susan I. Gibson
doaj   +2 more sources

Catharanthus roseus (L.) G. Don - plant regeneration and alkaloids content

Acta Societatis Botanicorum Poloniae, 2014
We describe here a regeneration of plantlets of Catharanthus roseus (L.) G. Don from shoot tips and axillary buds. Shoot tips were excised from 7-day-old seedlings and were incubated in solid Nitsch and Nitsch (NN) medium supplemented with kinetin ...
Mirosława Furmanowa, Hanna Olędzka, Joanna Józefowicz, Agnieszka Pietrosiuk   +3 more
doaj   +1 more source

Phytochemical profiling of Vinca rosea and antifungal potential of the leaf extract and isolated compound vindoline against wheat pathogens from the northern part of India

Discover Plants
Natural products significantly impact the pharmaceutical and agricultural industries, especially as “eco-friendly” alternatives to synthetic fungicides.
Parul Sharma, Ramandeep Kaur, J. Kaur, U. Bhardwaj   +3 more
semanticscholar   +1 more source

Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective

Molecules, 2021
Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities.
Faisal Omar, Abu Montakim Tareq, Ali M. Alqahtani, Kuldeep Dhama, Mohammed Abu Sayeed, Talha Bin Emran, Jesus Simal-Gandara   +6 more
doaj   +1 more source

Effects of Adding Vindoline and MeJA on Production of Vincristine and Vinblastine, and Transcription of their Biosynthetic Genes in the Cultured CMCs of

Natural Product Communications, 2015
Vincristine and vinblastine were found by Liquid Chromatography-Mass Spectrometry (LC-MS) in Catharanthus roseus cambial meristem cells (CMCs) jointly treated with 0.25 mM vindolineand methyl jasmonate (MeJA), suggesting that C.
Wenjin Zhang, Jiazeng Yang, Jiachen Zi, Jianhua Zhu, Liyan Song, Rongmin Yu   +5 more
doaj   +1 more source