Results 41 to 50 of about 1,375 (189)

Red–Blue LED Light and Plasma-Activated Water Enhance Vindoline and Catharanthine Yields in Catharanthus roseus Grown in a Closed Plant Production System

Plants
Madagascar periwinkle [Catharanthus roseus (L.) G. Don] produces vindoline and catharanthine, key precursors used in the semi-synthesis of the high-value anticancer alkaloids vinblastine and vincristine.
Alessandro Quadri, Mattia Trenta, Bianca Sambuco, Patrizia Tassinari, Daniele Torreggiani, Assunta Bertaccini, Laura Mercolini, Michele Protti, Francesco Tomelleri, Romolo Laurita, Alberto Barbaresi   +10 more
doaj   +1 more source

Effects of Adding Vindoline and MeJA on Production of Vincristine and Vinblastine, and Transcription of their Biosynthetic Genes in the Cultured CMCs of

Natural Product Communications, 2015
Vincristine and vinblastine were found by Liquid Chromatography-Mass Spectrometry (LC-MS) in Catharanthus roseus cambial meristem cells (CMCs) jointly treated with 0.25 mM vindolineand methyl jasmonate (MeJA), suggesting that C.
Wenjin Zhang, Jiazeng Yang, Jiachen Zi, Jianhua Zhu, Liyan Song, Rongmin Yu   +5 more
doaj   +1 more source

A Golgi‐localized N‐methyltransferase and reversible aldo–keto reductases coordinate dual terminal routes in galanthamine biosynthesis

The Plant Journal, Volume 126, Issue 6, June 2026.
Significant Statement This study identifies LaTMT2, a Golgi‐localized N‐methyltransferase, and three reversible aldo–keto reductases (LaAKR1 and LaAKR3) as key enzymes coordinating the dual terminal routes of galanthamine biosynthesis in Leucojum aestivum.
Basanta Lamichhane, Archana Niraula, Natacha Merindol, Sarah‐Eve Gélinas, Patrick Lagüe, Simon Ricard, Hugo Germain, Isabel Desgagné‐Penix   +7 more
wiley   +1 more source

Identification and characterization of BAHD hydroxycinnamoyltransferases in the fern Neoblechnum brasiliense

The Plant Journal, Volume 126, Issue 1, April 2026.
Significance Statement Nine BAHD acyltransferases have been identified and characterized in the fern Neoblechnum brasiliense transferring hydroxycinnamoyl units onto various alcohol and amine acceptor substrates. Kinetic characterization showed that shikimic and quinic acids for ester formation as well as 3‐hydroxyanthranilic acid and tryptamine for ...
Maximilian Ufland, Maike Petersen
wiley   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, Volume 36, Issue 16, 23 February 2026.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

The Suzuki-Miyaura reaction in the chemical transformations of vindoline [PDF]

, 2007
Vindoline and its analogues are important constituents of the Madagascan periwinkle Catharanthus roseus, and some of them are valuable chemotherapy drugs used in treatment for some types of cancer, including leukaemia, lymphoma, breast and lung cancer ...
Czarnocki, Zbigniew, Chrobak, Robert, Żero, Paweł, Maurin, Jan, Szawkało, Joanna, Ruszkowska, Joanna   +5 more
core  

Formal total synthesis of (+/-)Vindoline by tandem radical cyclization

, 2001
This is a meeting abstract that discusses formal total synthesis of (+/-)Vindoline by tandem radical ...
Murphy, J.A., Zhou, S.Z., Bommezijn, S.
core   +2 more sources

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)

Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni, Milena Costa Bassicheto, Maria Vitória de Oliveira, Ana Beatriz dos Santos de Souza, Gabriella Melo Alves, Thiago André Moura Veiga   +5 more
wiley   +1 more source

Total Synthesis of (−)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile

, 2015
It is reported that an allene dienophile can initiate a tandem intramolecular [4 + 2]/[3 + 2] cycloaddition cascade of 1,3,4-oxadiazoles, that the intermediate cross-conjugated 1,3-dipole (a carbonyl ylide) can participate in an ensuing [3 + 2] dipolar ...
Dale L. Boger (1306542), Timothy J. Barker (1491016), Justin E. Sears (1491019)   +2 more
core   +1 more source

Effects of PEG-induced drought stress on regulation of indole alkaloid biosynthesis in Catharanthus roseus

Journal of Plant Interactions, 2017
Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu, Qinghuan Meng, Xihua Duan, Zhonghua Zhang, Dewen Li   +4 more
doaj   +1 more source