Results 21 to 30 of about 1,258 (192)

Addition of Vindoline to p-Benzoquinone: Regiochemistry, Stereochemistry and Symmetry Considerations

Molecules, 2021
Vindoline and catharanthine are the major alkaloids of Catharanthus roseus and are extracted in large quantities to prepare the pharmaceutically important Vinca type alkaloids vincaleukoblastine, vincristine and navelbine.
Shamsher Ali, Eric Hénon, Ritchy Leroy, Georges Massiot   +3 more
doaj   +1 more source

Exploration of the Mechanisms of Differential Indole Alkaloid Biosynthesis in Dedifferentiated and Cambial Meristematic Cells of Catharanthus roseus Using Transcriptome Sequencing

Frontiers in Genetics, 2022
Catharanthus roseus produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The current research focuses on finding an efficient production system such as cell suspension cultures for high TIA concentrations.
Pengfei Zhou, Mingxiang Chen
doaj   +1 more source

Synthesis and In Vitro Evaluation of the Anticancer Effect of Novel Phosphonium Vindoline Derivatives. [PDF]

Int J Mol Sci
The Vinca alkaloid vindoline was coupled at position 17 with several trisubstituted phosphine derivatives and their in vitro anticancer activities on 60 human tumor cell lines (NCI60) were investigated.
Halmai M, Donkó-Tóth V, Keglevich P, Kánai K, Weber M, Dékány M, Abdallah EA, Bózsity N, Zupkó I, Nehr-Majoros A, Szőke É, Helyes Z, Hazai L.   +12 more
europepmc   +2 more sources

Total Synthesis of (−)- and ent-(+)-Vindoline [PDF]

Organic Letters, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Younggi, Choi, Hayato, Ishikawa, Juraj, Velcicky, Gregory I, Elliott, Michael M, Miller, Dale L, Boger   +5 more
openaire   +6 more sources

Endophytic bacteria of Catharanthus roseus as an alternative source of Vindoline and application of response surface methodology to enhance its production [PDF]

Archives of Biological Sciences, 2019
The requirement for novel, cost-effective pharmaceutical compounds is growing. We screened endophytic bacteria of Catharanthus roseus for the production of vinca alkaloids.
Anjum Nawed, Chandra Ramesh
doaj   +1 more source

Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice

Frontiers in Pharmacology, 2020
Osteolytic bone diseases, for example postmenopausal osteoporosis, arise from the imbalances between osteoclasts and osteoblasts in the bone remodeling process, whereby osteoclastic bone resorption greatly exceeds osteoblastic bone formation resulting in
Yunfei Zhan, Jiamin Liang, Kun Tian, Zhigang Che, Ziyi Wang, Xue Yang, Yuangang Su, Xixi Lin, Fangming Song, Fangming Song, Jinmin Zhao, Jinmin Zhao, Jiake Xu, Jiake Xu, Qian Liu, Qian Liu, Bo Zhou   +16 more
doaj   +1 more source

Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation

Marine Drugs, 2022
Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang   +3 more
doaj   +1 more source

Possible therapeutic effects of vindoline on testicular and epididymal function in diabetes-induced oxidative stress male Wistar rats

Heliyon, 2020
Objective: The study evaluated the effects of vindoline on testicular and epididymal oxidative stress in diabetes-induced male Wistar rats. Methods: Forty-eight (48), 6-week old male Wistar rats weighing between 190-230g were divided into 6 groups (n = 8)
Oluwafemi O. Oguntibeju, Yapo Aboua, Prisca Kachepe   +2 more
doaj   +1 more source

Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts

Frontiers in Pharmacology, 2022
Disruption of extracellular matrix (ECM) homeostasis and subchondral bone remodeling play significant roles in osteoarthritis (OA) pathogenesis. Vindoline (Vin), an indole alkaloid extracted from the medicinal plant Catharanthus roseus, possesses anti ...
Meisong Zhu, Qiang Xu, Xinmin Yang, Haibo Zhan, Bin Zhang, Xuqiang Liu, Min Dai   +6 more
doaj   +1 more source

Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings

Molecules, 2018
Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich, Szabolcs Mayer, Réka Pápai, Áron Szigetvári, Zsuzsanna Sánta, Miklós Dékány, Csaba Szántay, Péter Keglevich, László Hazai   +8 more
doaj   +1 more source