Results 21 to 30 of about 2,154 (205)

Exploration of the Mechanisms of Differential Indole Alkaloid Biosynthesis in Dedifferentiated and Cambial Meristematic Cells of Catharanthus roseus Using Transcriptome Sequencing

Frontiers in Genetics, 2022
Catharanthus roseus produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The current research focuses on finding an efficient production system such as cell suspension cultures for high TIA concentrations.
Pengfei Zhou, Mingxiang Chen
doaj   +1 more source

Endophytic bacteria of Catharanthus roseus as an alternative source of Vindoline and application of response surface methodology to enhance its production [PDF]

Archives of Biological Sciences, 2019
The requirement for novel, cost-effective pharmaceutical compounds is growing. We screened endophytic bacteria of Catharanthus roseus for the production of vinca alkaloids.
Anjum Nawed, Chandra Ramesh
doaj   +1 more source

Total Synthesis of (−)- and ent-(+)-Vindoline [PDF]

Organic Letters, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Younggi, Choi, Hayato, Ishikawa, Juraj, Velcicky, Gregory I, Elliott, Michael M, Miller, Dale L, Boger   +5 more
openaire   +6 more sources

Novel Piperazine Derivatives of Vindoline as Anticancer Agents. [PDF]

Int J Mol Sci
A series of novel vindoline–piperazine conjugates were synthesized by coupling 6 N-substituted piperazine pharmacophores at positions 10 and 17 of Vinca alkaloid monomer vindoline through different types of linkers. The in vitro antiproliferative activity of the 17 new conjugates was investigated on 60 human tumor cell lines (NCI60).
Zsoldos B, Nagy N, Donkó-Tóth V, Keglevich P, Weber M, Dékány M, Nehr-Majoros A, Szőke É, Helyes Z, Hazai L.   +9 more
europepmc   +3 more sources

Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice

Frontiers in Pharmacology, 2020
Osteolytic bone diseases, for example postmenopausal osteoporosis, arise from the imbalances between osteoclasts and osteoblasts in the bone remodeling process, whereby osteoclastic bone resorption greatly exceeds osteoblastic bone formation resulting in
Yunfei Zhan, Jiamin Liang, Kun Tian, Zhigang Che, Ziyi Wang, Xue Yang, Yuangang Su, Xixi Lin, Fangming Song, Fangming Song, Jinmin Zhao, Jinmin Zhao, Jiake Xu, Jiake Xu, Qian Liu, Qian Liu, Bo Zhou   +16 more
doaj   +1 more source

Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation

Marine Drugs, 2022
Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang   +3 more
doaj   +1 more source

Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts

Frontiers in Pharmacology, 2022
Disruption of extracellular matrix (ECM) homeostasis and subchondral bone remodeling play significant roles in osteoarthritis (OA) pathogenesis. Vindoline (Vin), an indole alkaloid extracted from the medicinal plant Catharanthus roseus, possesses anti ...
Meisong Zhu, Qiang Xu, Xinmin Yang, Haibo Zhan, Bin Zhang, Xuqiang Liu, Min Dai   +6 more
doaj   +1 more source

Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings

Molecules, 2018
Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich, Szabolcs Mayer, Réka Pápai, Áron Szigetvári, Zsuzsanna Sánta, Miklós Dékány, Csaba Szántay, Péter Keglevich, László Hazai   +8 more
doaj   +1 more source

Vindoline—A Natural Product from Catharanthus Roseus Reduces Hyperlipidemia and Renal Pathophysiology in Experimental Type 2 Diabetes

Biomedicines, 2019
Cardiovascular diseases (CVDs) and kidney diseases in diabetes are linked to increased mortality and morbidity. The aim of this study was to evaluate the effect of vindoline derived from Catharanthus roseus in diabetes-induced CVDs and kidney disease ...
Oluwafemi Omoniyi Oguntibeju, Yapo Aboua, Mediline Goboza   +2 more
doaj   +1 more source

Spatial transcriptomics drives a new era in plant research

The Plant Journal, Volume 116, Issue 6, Page 1571-1581, December 2023., 2023
SUMMARY The plant community lags far behind the animal and human fields concerning the application of single‐cell methodologies. This is primarily due to the challenges associated with plant tissue dissection and the limitations of the available technologies.
Ruilian Yin, Keke Xia, Xun Xu
wiley   +1 more source