Results 1 to 10 of about 1,727 (188)

Novel Piperazine Derivatives of Vindoline as Anticancer Agents [PDF]

International Journal of Molecular Sciences
A series of novel vindoline–piperazine conjugates were synthesized by coupling 6 N-substituted piperazine pharmacophores at positions 10 and 17 of Vinca alkaloid monomer vindoline through different types of linkers.
Miklós Dekany, László Hazai, Peter Keglevich   +2 more
exaly   +5 more sources

De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces cerevisiae

BioDesign Research, 2022
Vinblastine has been used clinically as one of the most potent therapeutics for the treatment of several types of cancer. However, the traditional plant extraction method suffers from unreliable supply, low abundance, and extremely high cost.
Di Gao, Tengfei Liu, Jucan Gao, Junhao Xu, Yuanwei Gou, Yingjia Pan, Dongfang Li, Cuifang Ye, Ronghui Pan, Lei Huang, Zhinan Xu, Jiazhang Lian   +11 more
doaj   +4 more sources

Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories [PDF]

Microbial Biotechnology, 2021
Summary The pharmaceutical industry faces a growing demand and recurrent shortages in many anticancer plant drugs given their extensive use in human chemotherapy.
Natalja Kulagina, Grégory Guirimand, Céline Melin, Pamela Lemos‐Cruz, Ines Carqueijeiro, Johan‐Owen De Craene, Audrey Oudin, Vladimir Heredia, Konstantinos Koudounas, Marianne Unlubayir, Arnaud Lanoue, Nadine Imbault, Benoit St‐Pierre, Nicolas Papon, Marc Clastre, Nathalie Giglioli‐Guivarc’h, Jillian Marc, Sébastien Besseau, Vincent Courdavault   +18 more
doaj   +4 more sources

Synthesis and Cytotoxic Activity of New Vindoline Derivatives Coupled to Natural and Synthetic Pharmacophores

Molecules, 2020
New Vinca alkaloid derivatives were synthesized to improve the biological activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole ...
László Hazai, Attila Hunyadi, István Zupko   +2 more
exaly   +4 more sources

Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae

Communications Biology, 2021
Liu et al. optimize vindoline biosynthesis in yeast from tabersonine by altering the copy numbers of pathway genes, pairing CYPs with CPRs, engineering the microenvironment for functional expression of CYPs, enhancing cofactor supplies, and optimizing ...
Tengfei Liu, Ying Huang, Lihong Jiang, Chang Dong, Yuanwei Gou, Jiazhang Lian   +5 more
doaj   +2 more sources

Identification of DELLA and GID1 genes in Catharanthus roseus and their potential role in regulating vindoline biosynthesis. [PDF]

Plant Mol Biol
DELLAs are key regulators of plant growth and development, negatively regulating gibberellic acid (GA) signaling and positively regulating light and jasmonate signaling and juvenile leaf development. In the presence of GA, GID1s bind to DELLAs and signal
Cole-Osborn LF, Soens N, Bernal-Franco D, Prifti O, Cram EJ, Lee-Parsons CWT.   +5 more
europepmc   +2 more sources

Vindoline Exhibits Anti-Diabetic Potential in Insulin-Resistant 3T3-L1 Adipocytes and L6 Skeletal Myoblasts. [PDF]

Nutrients, 2023
Type 2 diabetes mellitus (T2DM) emerged as a major health care concern in modern society, primarily due to lifestyle changes and dietary habits. Obesity-induced insulin resistance is considered as the major pathogenic factor in T2DM.
Shijina BN, Radhika A, Sherin S, Biju PG.   +3 more
europepmc   +2 more sources

Synthesis and In Vitro Evaluation of the Anticancer Effect of Novel Phosphonium Vindoline Derivatives. [PDF]

Int J Mol Sci
The Vinca alkaloid vindoline was coupled at position 17 with several trisubstituted phosphine derivatives and their in vitro anticancer activities on 60 human tumor cell lines (NCI60) were investigated.
Halmai M, Donkó-Tóth V, Keglevich P, Kánai K, Weber M, Dékány M, Abdallah EA, Bózsity N, Zupkó I, Nehr-Majoros A, Szőke É, Helyes Z, Hazai L.   +12 more
europepmc   +2 more sources

Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation

Marine Drugs, 2022
Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang   +3 more
doaj   +2 more sources

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Molecules, 2021
Plant specialized metabolites are widely used in the pharmaceutical industry, including the monoterpene indole alkaloids (MIAs) vinblastine and vincristine, which both display anticancer activity.
Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc’h, Nicolas Papon, Marc Clastre, Vincent Courdavault   +10 more
doaj   +2 more sources