De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces cerevisiae
BioDesign Research, 2022 Vinblastine has been used clinically as one of the most potent therapeutics for the treatment of several types of cancer. However, the traditional plant extraction method suffers from unreliable supply, low abundance, and extremely high cost.
Di Gao +11 more
doaj +3 more sources
Integrated metabolomic, network pharmacological, and molecular docking analyses comparing the therapeutic effects of Strobilanthes sarcorrhiza from different origins [PDF]
Scientific ReportsStrobilanthes sarcorrhiza, a characteristic medicinal plant in China, has been traditionally used for nourishing yin and tonifying kidneys through its fleshy roots.
Wenyuan Xie +7 more
doaj +2 more sources
Conversion of Vindoline into 11-Mesyloxytabersonine
Chemical and Pharmaceutical Bulletin, 2016 Conversion of readily available vindoline to 11-mesyloxytabersonine, a versatile synthetic intermediate for indole alkaloids, has been achieved by a 9-step sequence in 39% overall yield.
Satoshi Yokoshima, Hidetoshi Tokuyama
exaly +4 more sources
Magnesium Plus Hydrogen Fertilization Enhances Mg Uptake, Growth Performance and Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus [PDF]
PlantsMagnesium and hydrogen fertilization have been reported to contribute to plant growth and metabolite production. Simultaneous fertilization of magnesium and hydrogen is a promising strategy for plant development and secondary metabolism, but remains ...
Chaoqin Ou +9 more
doaj +2 more sources
Molecules, 2020 New Vinca alkaloid derivatives were synthesized to improve the biological activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole ...
András Keglevich +2 more
exaly +3 more sources
Transcriptomic profiling and oxidative stress responses of Catharanthus roseus under short-term LED light exposure [PDF]
BMC Plant BiologyAs the application of LED light on plants is increasing for development of efficient, sustainable, and innovative agricultural strategies, comprehensive knowledge towards response mechanisms of plants under such artificial light source is less known.
Zhuoheng Zhong +5 more
doaj +2 more sources
Novel Piperazine Derivatives of Vindoline as Anticancer Agents. [PDF]
Int J Mol SciA series of novel vindoline–piperazine conjugates were synthesized by coupling 6 N-substituted piperazine pharmacophores at positions 10 and 17 of Vinca alkaloid monomer vindoline through different types of linkers. The in vitro antiproliferative activity of the 17 new conjugates was investigated on 60 human tumor cell lines (NCI60).
Zsoldos B +9 more
europepmc +3 more sources
Electrospray–Mass Spectrometry-Guided Targeted Isolation of Indole Alkaloids from Leaves of Catharanthus roseus by Using High-Performance Countercurrent Chromatography [PDF]
MoleculesElectrospray mass spectrometry off-line profiling monitored the recovery of targeted indole alkaloids from a fortified crude extract of Catharanthus roseus (790 mg) using semi-preparative high-performance countercurrent chromatography (HPCCC ...
Mahdi Yahyazadeh +2 more
doaj +2 more sources
A Cotyledon-based Virus-Induced Gene Silencing (Cotyledon-VIGS) approach to study specialized metabolism in medicinal plants [PDF]
Plant MethodsBackground Virus-induced gene silencing (VIGS) is widely used in plant functional genomics. However, the efficiency of VIGS in young plantlets varies across plant species.
Yongliang Liu +5 more
doaj +2 more sources
Comprehensive analysis of SPL gene family and miR156a/SPLs in the regulation of terpenoid indole alkaloid biosynthesis in Catharanthus roseus L [PDF]
BMC Plant BiologyBackground Catharanthus roseus (C. roseus), belongs to the dogbane family Apocynaceae, is the source of various terpenoid indole alkaloids (TIAs) with excellent antitumor properties, including vinblastine, vincristine, ajmalicine, serpentine, vindoline ...
Yaojie Zhang +9 more
doaj +2 more sources