De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces cerevisiae [PDF]
BioDesign Research, 2022 Vinblastine has been used clinically as one of the most potent therapeutics for the treatment of several types of cancer. However, the traditional plant extraction method suffers from unreliable supply, low abundance, and extremely high cost.
Di Gao +11 more
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Heliyon, 2020 Objective: The study evaluated the effects of vindoline on testicular and epididymal oxidative stress in diabetes-induced male Wistar rats. Methods: Forty-eight (48), 6-week old male Wistar rats weighing between 190-230g were divided into 6 groups (n = 8)
Oluwafemi Omoniyi Oguntibeju
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Integrated metabolomic, network pharmacological, and molecular docking analyses comparing the therapeutic effects of Strobilanthes sarcorrhiza from different origins [PDF]
Scientific ReportsStrobilanthes sarcorrhiza, a characteristic medicinal plant in China, has been traditionally used for nourishing yin and tonifying kidneys through its fleshy roots.
Wenyuan Xie +7 more
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Magnesium Plus Hydrogen Fertilization Enhances Mg Uptake, Growth Performance and Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus [PDF]
PlantsMagnesium and hydrogen fertilization have been reported to contribute to plant growth and metabolite production. Simultaneous fertilization of magnesium and hydrogen is a promising strategy for plant development and secondary metabolism, but remains ...
Chaoqin Ou +9 more
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Molecules, 2020 New Vinca alkaloid derivatives were synthesized to improve the biological activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole ...
Attila Hunyadi +2 more
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Genome-wide identification of NAC transcription factors and regulation of monoterpenoid indole alkaloid biosynthesis in Catharanthus roseus [PDF]
Frontiers in Plant Science, 2023 NAC transcription factors (TFs) are crucial to growth and defense responses in plants. Though NACs have been characterized for their role in several plants, comprehensive information regarding their role in Catharanthus roseus, a perennial ornamental ...
Jawad Ahmed +9 more
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Transcriptomic profiling and oxidative stress responses of Catharanthus roseus under short-term LED light exposure [PDF]
BMC Plant BiologyAs the application of LED light on plants is increasing for development of efficient, sustainable, and innovative agricultural strategies, comprehensive knowledge towards response mechanisms of plants under such artificial light source is less known.
Zhuoheng Zhong +5 more
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Electrospray–Mass Spectrometry-Guided Targeted Isolation of Indole Alkaloids from Leaves of Catharanthus roseus by Using High-Performance Countercurrent Chromatography [PDF]
MoleculesElectrospray mass spectrometry off-line profiling monitored the recovery of targeted indole alkaloids from a fortified crude extract of Catharanthus roseus (790 mg) using semi-preparative high-performance countercurrent chromatography (HPCCC ...
Mahdi Yahyazadeh +2 more
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A Cotyledon-based Virus-Induced Gene Silencing (Cotyledon-VIGS) approach to study specialized metabolism in medicinal plants [PDF]
Plant MethodsBackground Virus-induced gene silencing (VIGS) is widely used in plant functional genomics. However, the efficiency of VIGS in young plantlets varies across plant species.
Yongliang Liu +5 more
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Vindoline Exhibits Anti-Diabetic Potential in Insulin-Resistant 3T3-L1 Adipocytes and L6 Skeletal Myoblasts [PDF]
Nutrients, 2023 Prabath Biju
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