Results 11 to 20 of about 1,727 (188)

Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts

Frontiers in Pharmacology, 2022
Disruption of extracellular matrix (ECM) homeostasis and subchondral bone remodeling play significant roles in osteoarthritis (OA) pathogenesis. Vindoline (Vin), an indole alkaloid extracted from the medicinal plant Catharanthus roseus, possesses anti ...
Meisong Zhu, Qiang Xu, Xinmin Yang, Haibo Zhan, Bin Zhang, Xuqiang Liu, Min Dai   +6 more
doaj   +2 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

In Vitro Antidiabetic and Antioxidant Effects of Different Extracts of Catharanthus roseus and Its Indole Alkaloid, Vindoline

Molecules, 2020
The Catharanthus roseus plant has been used traditionally to treat diabetes mellitus. Scientific evidence supporting the antidiabetic effects of this plant’s active ingredient-vindoline has not been fully evaluated. In this study, extracts of C.
Mediline Goboza, Mervin Meyer, Yapo G. Aboua, Oluwafemi O. Oguntibeju   +3 more
doaj   +2 more sources

PIFA-Mediated Coupling of Vindoline with β-Ketoesters and Related Model Velbanamine Precursors. [PDF]

Synlett
A study of [bis(trifluoroacetoxy)iodo]benzene(PIFA)-mediated arylations of advanced model β-ketoesters and related substrates with vindoline for the total synthesis of vinblastine and related analogues is reported.
Zhang J, Haddadpour N, Cai B, Boger DL.
europepmc   +2 more sources

Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice

Frontiers in Pharmacology, 2020
Osteolytic bone diseases, for example postmenopausal osteoporosis, arise from the imbalances between osteoclasts and osteoblasts in the bone remodeling process, whereby osteoclastic bone resorption greatly exceeds osteoblastic bone formation resulting in
Yunfei Zhan, Jiamin Liang, Kun Tian, Zhigang Che, Ziyi Wang, Xue Yang, Yuangang Su, Xixi Lin, Fangming Song, Fangming Song, Jinmin Zhao, Jinmin Zhao, Jiake Xu, Jiake Xu, Qian Liu, Qian Liu, Bo Zhou   +16 more
doaj   +2 more sources

Transcriptional Reprogramming Deploys a Compartmentalized 'Timebomb' in Catharanthus roseus to Fend Off Chewing Herbivores. [PDF]

Plant Cell Environ
ABSTRACT The evolutionary arms race between plants and insects has led to key adaptive innovations that drive diversification. Alkaloids are well‐documented anti‐herbivory compounds in plant chemical defences, but how these specialized metabolites are allocated to cope with both biotic and abiotic stresses concomitantly is largely unknown.
Liu Y, Shi J, Patra B, Singh SK, Wu X, Lyu R, Liu X, Li Y, Wang Y, Zhou X, Pattanaik S, Yuan L.   +11 more
europepmc   +2 more sources

Possible therapeutic effects of vindoline on testicular and epididymal function in diabetes-induced oxidative stress male Wistar rats

Heliyon, 2020
Objective: The study evaluated the effects of vindoline on testicular and epididymal oxidative stress in diabetes-induced male Wistar rats. Methods: Forty-eight (48), 6-week old male Wistar rats weighing between 190-230g were divided into 6 groups (n = 8)
Oluwafemi O. Oguntibeju, Yapo Aboua, Prisca Kachepe   +2 more
doaj   +2 more sources

Phenotypic, genetic and expression profiling of a vindoline-rich genotype of Catharanthus roseus

South African Journal of Botany, 2021
Catharanthus roseus is known for its scarce and expensive anticancer bisindole alkaloids, vincristine and vinblastine, which are derived from the coupling of monomeric terpenoid indole alkaloids, catharanthine and vindoline.
Maneesha Mall, Puja Khare, V Sundaresan   +2 more
exaly   +2 more sources

Synthesis and Antiproliferative Effect of New Alkyne-Tethered Vindoline Hybrids Containing Pharmacophoric Fragments. [PDF]

Int J Mol Sci
In the frame of our diversity-oriented research on multitarget small molecule anticancer agents, utilizing convergent synthetic sequences terminated by Sonogashira coupling reactions, a preliminary selection of representative alkyne-tethered vindoline ...
Ferenczi E, Keglevich P, Tayeb BA, Minorics R, Papp D, Schlosser G, Zupkó I, Hazai L, Csámpai A.   +8 more
europepmc   +2 more sources

Conversion of Vindoline into 11-Mesyloxytabersonine

Chemical and Pharmaceutical Bulletin, 2016
Conversion of readily available vindoline to 11-mesyloxytabersonine, a versatile synthetic intermediate for indole alkaloids, has been achieved by a 9-step sequence in 39% overall yield.
Hidetoshi Tokuyama, Satoshi Yokoshima
exaly   +4 more sources