Results 11 to 20 of about 1,258 (192)

In Vitro Antidiabetic and Antioxidant Effects of Different Extracts of Catharanthus roseus and Its Indole Alkaloid, Vindoline

Molecules, 2020
The Catharanthus roseus plant has been used traditionally to treat diabetes mellitus. Scientific evidence supporting the antidiabetic effects of this plant’s active ingredient-vindoline has not been fully evaluated. In this study, extracts of C.
Mediline Goboza, Mervin Meyer, Yapo G. Aboua, Oluwafemi O. Oguntibeju   +3 more
doaj   +3 more sources

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Molecules, 2021
Plant specialized metabolites are widely used in the pharmaceutical industry, including the monoterpene indole alkaloids (MIAs) vinblastine and vincristine, which both display anticancer activity.
Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc’h, Nicolas Papon, Marc Clastre, Vincent Courdavault   +10 more
doaj   +2 more sources

Vindoline—A Natural Product from Catharanthus Roseus Reduces Hyperlipidemia and Renal Pathophysiology in Experimental Type 2 Diabetes

Biomedicines, 2019
Cardiovascular diseases (CVDs) and kidney diseases in diabetes are linked to increased mortality and morbidity. The aim of this study was to evaluate the effect of vindoline derived from Catharanthus roseus in diabetes-induced CVDs and kidney disease ...
Oluwafemi Omoniyi Oguntibeju, Yapo Aboua, Mediline Goboza   +2 more
doaj   +2 more sources

Attempted Diels-Alder Reactions on Vindoline Derivatives

Periodica Polytechnica Chemical Engineering, 2017
The Diels-Alder reaction of vindoline and methyl vinyl ketone resulted in a Friedel-Crafts reaction product. In the reaction between the ortho-quinone derivative of vindoline and N-phenylmaleimide, two anomalous products were obtained, a vindoline dimer, and a condensed vindoline derivative.
Szabolcs Mayer, Péter Keglevich, Péter Ábrányi-Balogh, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Jr., László Hazai   +6 more
openaire   +3 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Transcriptional Reprogramming Deploys a Compartmentalized 'Timebomb' in Catharanthus roseus to Fend Off Chewing Herbivores. [PDF]

Plant Cell Environ
ABSTRACT The evolutionary arms race between plants and insects has led to key adaptive innovations that drive diversification. Alkaloids are well‐documented anti‐herbivory compounds in plant chemical defences, but how these specialized metabolites are allocated to cope with both biotic and abiotic stresses concomitantly is largely unknown.
Liu Y, Shi J, Patra B, Singh SK, Wu X, Lyu R, Liu X, Li Y, Wang Y, Zhou X, Pattanaik S, Yuan L.   +11 more
europepmc   +2 more sources

Vindoline Exhibits Anti-Diabetic Potential in Insulin-Resistant 3T3-L1 Adipocytes and L6 Skeletal Myoblasts. [PDF]

Nutrients, 2023
Type 2 diabetes mellitus (T2DM) emerged as a major health care concern in modern society, primarily due to lifestyle changes and dietary habits. Obesity-induced insulin resistance is considered as the major pathogenic factor in T2DM.
Shijina BN, Radhika A, Sherin S, Biju PG.   +3 more
europepmc   +2 more sources

Asymmetric Total Synthesis of Vindoline [PDF]

Journal of the American Chemical Society, 2010
A concise asymmetric total synthesis of (-)-vindoline (1) is detailed based on a tandem intramolecular [4+2]/[3+2] cycloaddition cascade of a 1,3,4-oxadiazole inspired by the natural product structure, in which the tether linking the initiating dienophile and oxadiazole bears a chiral substituent that controls the facial selectivity of the initiating ...
Daisuke, Kato, Yoshikazu, Sasaki, Dale L, Boger   +2 more
openaire   +5 more sources

Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories

Microbial Biotechnology, 2021
Summary The pharmaceutical industry faces a growing demand and recurrent shortages in many anticancer plant drugs given their extensive use in human chemotherapy.
Natalja Kulagina, Grégory Guirimand, Céline Melin, Pamela Lemos‐Cruz, Ines Carqueijeiro, Johan‐Owen De Craene, Audrey Oudin, Vladimir Heredia, Konstantinos Koudounas, Marianne Unlubayir, Arnaud Lanoue, Nadine Imbault, Benoit St‐Pierre, Nicolas Papon, Marc Clastre, Nathalie Giglioli‐Guivarc’h, Jillian Marc, Sébastien Besseau, Vincent Courdavault   +18 more
doaj   +1 more source

Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae

Communications Biology, 2021
Liu et al. optimize vindoline biosynthesis in yeast from tabersonine by altering the copy numbers of pathway genes, pairing CYPs with CPRs, engineering the microenvironment for functional expression of CYPs, enhancing cofactor supplies, and optimizing ...
Tengfei Liu, Ying Huang, Lihong Jiang, Chang Dong, Yuanwei Gou, Jiazhang Lian   +5 more
doaj   +1 more source