Molecules, 2023 Allenes with two carbon–carbon double bonds belong to a unique class of unsaturated hydrocarbons. The central carbon atom of allene is sp hybridized and forms two σ-bonds and two π-bonds with two terminal sp2 hybridized carbon atoms.
Sana Sikandar +8 more
doaj +1 more source
The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway [PDF]
, 2013 Background: The terpenoid indole alkaloid (TIA) pathway leads to the production of pharmaceutically important drugs, such as the anticancer compounds vinblastine and vincristine.
Gibson, Susan +6 more
core +3 more sources
Electrochemically Enabled Total Syntheses of Natural Products
ChemElectroChem, Volume 10, Issue 11, June 1, 2023., 2023 Electrochemical synthesis is a powerfully enabling technique for the formation of carbon‐carbon and carbon‐heteroatom bonds and has driven new developments in the total synthesis of complex bioactive natural products for 175 years. This review explores the unusual disconnections and operationally simple approaches to a diverse array of natural products.
Chad E. Hatch, William J. Chain
wiley +1 more source
Bioproduction of monoterpene indole alkaloids in a single cell factory
Engineering Microbiology, 2022 The de novo biosynthesis of vindoline and catharanthine, the direct precursors used for industrial production of the anti-cancer drug vinblastine, has been achieved in the yeast cell factory.
Jianping Huang, Shengxiong Huang
doaj +1 more source
Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"? [PDF]
, 2010 Background The first two enzymatic steps of monoterpene indole alkaloid (MIA) biosynthetic pathway are catalysed by strictosidine synthase (STR) that condensates tryptamine and secologanin to form strictosidine and by strictosidine β-D-glucosidase (SGD ...
Guirimand Grégory +8 more
core +1 more source
Global Change Biology, Volume 29, Issue 2, Page 477-504, January 2023., 2023 Plant secondary metabolites, including phenolic compounds, terpenoids and alkaloids, contribute critically to plant‐environmental interaction and human health and are expected to respond distinctively to ongoing climate changes. This meta‐analysis demonstrated the positive phenolic responses to elevated carbon dioxide and temperature, the different C ...
Yuming Sun +2 more
wiley +1 more source
Functional characterization of a melon alcohol acyl-transferase gene family involved in the biosynthesis of ester volatiles. Identification of the crucial role of a threonine residue for enzyme activity [PDF]
, 2005 Volatile esters, a major class of compounds contributing to the aroma of many fruit, are synthesized by alcohol acyl-transferases (AAT). We demonstrate here that, in Charentais melon (Cucumis melo var.
A. Aggelis +53 more
core +2 more sources
Genome-wide identification and expression analysis of TCP family genes in Catharanthus roseus
Frontiers in Plant Science, 2023 IntroductionThe anti-tumor vindoline and catharanthine alkaloids are naturally existed in Catharanthus roseus (C. roseus), an ornamental plant in many tropical countries.
Juan Hao +24 more
doaj +1 more source
Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
PeerJ, 2021 Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Chun Yao Li, Susan I. Gibson
doaj +2 more sources
Application of recombinant DNA technology to studies on plant secondary metabolism [PDF]
, 2001 This review which is concerned with the application of recombinant DNA technology to studies on plant secondary metabolism, presents the more common plant transformation strategies and shows how these genetic approaches are being used in attempts to ...
Yeoman, Michael M., Zárate, Rafael
core +1 more source