Results 71 to 80 of about 1,727 (188)

Genome‐based discovery of pachysiphine synthases in Tabernaemontana elegans

The Plant Journal, Volume 120, Issue 5, Page 1880-1900, December 2024.
Significance Statement While pachysiphine is a monoterpene indole alkaloid of high interest and the precursor of an anti‐Alzheimer compound, its biosynthesis involving the epoxidation of tabersonine remains uncharacterized. By sequencing and assembling the genome of Tabernaemontana elegans, we identified two P450s exhibiting a pachysiphine synthase ...
Enzo Lezin, Mickael Durand, Caroline Birer Williams, Ana Luisa Lopez Vazquez, Thomas Perrot, Nicolas Gautron, Julien Pétrignet, Clément Cuello, Hans J. Jansen, Florent Magot, Sarah Szwarc, Pierre Le Pogam, Mehdi A. Beniddir, Konstantinos Koudounas, Audrey Oudin, Benoit St‐Pierre, Nathalie Giglioli‐Guivarc'h, Chao Sun, Nicolas Papon, Michael Krogh Jensen, Ron P. Dirks, Sarah E. O'Connor, Sébastien Besseau, Vincent Courdavault   +23 more
wiley   +1 more source

Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis

The Plant Journal, Volume 120, Issue 6, Page 2770-2783, December 2024.
SUMMARY Cytochrome P450 monooxygenases (CYPs) are well known for their ability to catalyze diverse oxidation reactions, playing a significant role in the biosynthesis of various natural products. In the realm of monoterpenoid indole alkaloids (MIAs), one of the largest groups of alkaloids in nature, CYPs are integral to reactions such as hydroxylation,
Zhan Mai, Kyunghee Kim, Matthew Bailey Richardson, Daniel André Ramey Deschênes, Jorge Jonathan Oswaldo Garza‐Garcia, Mohammadamin Shahsavarani, Jacob Owen Perley, Destiny Ichechi Njoku, Ghislain Deslongchamps, Vincenzo De Luca, Yang Qu   +10 more
wiley   +1 more source

GATA and Phytochrome Interacting Factor Transcription Factors Regulate Light-Induced Vindoline Biosynthesis in Catharanthus roseus1[OPEN]

Plant Physiology, 2019
A regulatory module consisting of Phytochrome Interacting Factor (PIF) and GATA transcription factors regulates light-induced vindoline biosynthesis in Catharanthus roseus seedlings.
Yongliang Liu, Barunava Patra, Sitakanta Pattanaik, Ying Wang, Ling Yuan   +4 more
semanticscholar   +1 more source

The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia

Pediatric Blood &Cancer, Volume 71, Issue 11, November 2024.
Abstract An attractive flower from the island of Madagascar has in part saved the lives of thousands of children with acute lymphoblastic leukemia (ALL). Random mutations and alterations to the genome led to the evolution of genes encoding enzymes, which would provide the periwinkle flower an arsenal of secondary metabolites to survive within the ...
Jeffrey W. Taub, Steven A. Buck, Ana C. Xavier, Holly Edwards, Larry H. Matherly, Yubin Ge   +5 more
wiley   +1 more source

Transcriptome analysis of Catharanthus roseus for gene discovery and expression profiling. [PDF]

PLoS ONE, 2014
The medicinal plant, Catharanthus roseus, accumulates wide range of terpenoid indole alkaloids, which are well documented therapeutic agents. In this study, deep transcriptome sequencing of C.
Mohit Verma, Rajesh Ghangal, Raghvendra Sharma, Alok K Sinha, Mukesh Jain   +4 more
doaj   +1 more source

Procedures to evaluate potential of plants as natural food preservatives: Phytochemical characterization, novel extraction technology, and safety evaluation—A comprehensive review

Food Science &Nutrition, Volume 12, Issue 9, Page 6142-6156, September 2024.
The use of plant extracts and EOs as preservatives in food products is a growing trend. Artemisia revealed good antimicrobial and antioxidant effects. Artemisia can be a novel natural agent for food preservation. The recent developments in extraction of Artemisia are discussed.
Negin Ahmadi, Nazanin Mosleh, Mahta Yeganeh, Nadia Ahmadi, Sara Malakouti, Saleh Shahsavari, Reza Shahraki, Somaye Katebi, Mina Agapoor, Sonia Sadeghi, Karim Bagheri   +10 more
wiley   +1 more source

Negative-Pressure Cavitation Extraction of Four Main Vinca Alkaloids from <em>Catharanthus </em><em>r</em><em>oseus</em> Leaves

Molecules, 2012
In the present study, an improved method termed negative-pressure cavitation extraction (NPCE) followed by reverse phase high-performance liquid chromatography (RP-HPLC) was developed for the extraction and quantification of vindoline (VDL ...
Yuangang Zu, Xiaorui Guo, Yujie Fu, Meng Luo, Wei Wang, Liuqing Yang, Fansong Mu   +6 more
doaj   +1 more source

Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus

New Phytologist, Volume 242, Issue 3, Page 1156-1171, May 2024.
Summary In Catharanthus roseus, monoterpenoid indole alkaloids (MIAs) are produced through the cooperation of four cell types, with final products accumulating in specialized cells known as idioblasts and laticifers. To explore the relationship between cellular differentiation and cell type‐specific MIA metabolism, we analyzed the expression of MIA ...
Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda‐Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah E. O'Connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai   +15 more
wiley   +1 more source

Structure and Synthesis of Vindolicine and Derivatives

Chemistry &Biodiversity, Volume 21, Issue 4, April 2024.
Abstract This article describes the reaction of vindoline with formaldehyde and trimethyl orthoformate to prepare vindolicine, tris‐vindolicinyl methane and higher molecular weight homologues. The synthesis of 10‐formyl vindoline as an intermediate allowed further exploration of its chemistry, in particular the reaction with acetone which yielded a ...
Asia, Yousuf Sammer, Laure Vendier, Georges Massiot   +3 more
wiley   +1 more source

Artemisinic Acid Serves as a Novel Inducer to Enhance Biosynthesis of Terpenoid Indole Alkaloids in Cambial Meristematic Cells

Natural Product Communications, 2016
To investigate the effect of artemisinic acid (AA) on improving the production of terpenoid indole alkaloids (TIAs) of Catharanthus roseus cambial meristematic cells (CMCs), feeding AA to C.
Mingxuan Wang, Jiachen Zi, Jianhua Zhu, Shan Chen, Pu Wang, Liyan Song, Rongmin Yu   +6 more
doaj   +1 more source