Results 71 to 80 of about 2,154 (205)

A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules [PDF]

, 2017
Plants are an excellent source of drug leads. However availability is limited by access to source species, low abundance and recalcitrance to chemical synthesis.
Alain Goossens, Alberti, Anarat-Cappillino, Andersen-Ranberg, Anne Osbourn, Aymeric Leveau, Bastiaan Brouwer, Biazzi, Boutanaev, Brown, Carelli, DeLoache, Fukushima, Fukushima, Galanie, Geisler, Geu-Flores, Harvey, Hill, Itkin, James Reed, Karel Miettinen, Kemen, Khakimov, Kwok, Li, Liby, Maria A. O’Connell, Marsian, Medema, Michael J. Stephenson, Miettinen, Miettinen, Moses, Moses, Moses, Moses, Moses, Nielsen, Owen, Paddon, Patron, Paul Brett, Polturak, Qu, Rajniak, Rebecca J.M. Goss, Sainsbury, Sainsbury, Salmon, Seki, Seki, Shang, Shibuya, Thimmappa, Wang, Yasumoto, Zhang   +57 more
core   +2 more sources

The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia

Pediatric Blood &Cancer, Volume 71, Issue 11, November 2024.
Abstract An attractive flower from the island of Madagascar has in part saved the lives of thousands of children with acute lymphoblastic leukemia (ALL). Random mutations and alterations to the genome led to the evolution of genes encoding enzymes, which would provide the periwinkle flower an arsenal of secondary metabolites to survive within the ...
Jeffrey W. Taub, Steven A. Buck, Ana C. Xavier, Holly Edwards, Larry H. Matherly, Yubin Ge   +5 more
wiley   +1 more source

Role of Polyethylene Glycol in production of Anticancer Alkaloids Vincristine, Vinblastine, and Vindoline in Catharanthus roseus via Callus Culture

Kufa Journal for Agricultural Sciences
Periwinkle Cathranthus roseus  is an ornamental plant that produces over 200 alkaloids, including vincristine, vinblastine, and vindoline, which are used to treat various types of cancer.
Zainab Abdulwahid, Abdulminam Hussien Ali Al-Musawi, Abdullah Hamad Lafta   +2 more
doaj   +1 more source

A Systematic Review of Iran’s Medicinal Plants With Anticancer Effects [PDF]

, 2015
Increase in cases of various cancers has encouraged the researchers to discover novel, more effective drugs from plant sources. This study is a review of medicinal plants in Iran with already investigated anticancer effects on various cell lines.
Asadi-Samani, Majid., Aslani, Elahe., Kooti, Wesam., shirzad, Hedayatollah.   +3 more
core   +1 more source

Procedures to evaluate potential of plants as natural food preservatives: Phytochemical characterization, novel extraction technology, and safety evaluation—A comprehensive review

Food Science &Nutrition, Volume 12, Issue 9, Page 6142-6156, September 2024.
The use of plant extracts and EOs as preservatives in food products is a growing trend. Artemisia revealed good antimicrobial and antioxidant effects. Artemisia can be a novel natural agent for food preservation. The recent developments in extraction of Artemisia are discussed.
Negin Ahmadi, Nazanin Mosleh, Mahta Yeganeh, Nadia Ahmadi, Sara Malakouti, Saleh Shahsavari, Reza Shahraki, Somaye Katebi, Mina Agapoor, Sonia Sadeghi, Karim Bagheri   +10 more
wiley   +1 more source

Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus

New Phytologist, Volume 242, Issue 3, Page 1156-1171, May 2024.
Summary In Catharanthus roseus, monoterpenoid indole alkaloids (MIAs) are produced through the cooperation of four cell types, with final products accumulating in specialized cells known as idioblasts and laticifers. To explore the relationship between cellular differentiation and cell type‐specific MIA metabolism, we analyzed the expression of MIA ...
Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda‐Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah E. O'Connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai   +15 more
wiley   +1 more source

Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. [PDF]

PLoS ONE, 2012
In order to improve the production of the anticancer dimeric indole alkaloids in Catharanthuse roseus, much research has been dedicated to culturing cell lines, hairy roots, and efforts to elucidate the regulation of the monoterpenoid indole alkaloid ...
Qifang Pan, Quan Wang, Fang Yuan, Shihai Xing, Jingya Zhao, Young Hae Choi, Robert Verpoorte, Yuesheng Tian, Guofeng Wang, Kexuan Tang   +9 more
doaj   +1 more source

Structure and Synthesis of Vindolicine and Derivatives

Chemistry &Biodiversity, Volume 21, Issue 4, April 2024.
Abstract This article describes the reaction of vindoline with formaldehyde and trimethyl orthoformate to prepare vindolicine, tris‐vindolicinyl methane and higher molecular weight homologues. The synthesis of 10‐formyl vindoline as an intermediate allowed further exploration of its chemistry, in particular the reaction with acetone which yielded a ...
Asia, Yousuf Sammer, Laure Vendier, Georges Massiot   +3 more
wiley   +1 more source

Negative-Pressure Cavitation Extraction of Four Main Vinca Alkaloids from <em>Catharanthus </em><em>r</em><em>oseus</em> Leaves

Molecules, 2012
In the present study, an improved method termed negative-pressure cavitation extraction (NPCE) followed by reverse phase high-performance liquid chromatography (RP-HPLC) was developed for the extraction and quantification of vindoline (VDL ...
Yuangang Zu, Xiaorui Guo, Yujie Fu, Meng Luo, Wei Wang, Liuqing Yang, Fansong Mu   +6 more
doaj   +1 more source

Medicinal plants: A promising source of anti-diabetic agents in sub-Sahara Africa

Current Issues in Pharmacy and Medical Sciences, 2023
The rising burden of Diabetes mellitus (DM) globally and particularly in sub-Sahara Africa calls for alternative treatment solutions. This is because the currently available drugs for its management are limited due to undesirable adverse effects and high
Aloke Chinyere, Egwu Chinedu Ogbonnia, Adelusi Oluwasola Abayomi, Chinaka Nnamdi, Kanu Shedrach Chidiebere, Ogbodo Peace Nzubuchukwu, Akumadu Blessing Oluebube, Achilonu Ikechukwu   +7 more
doaj   +1 more source