Results 1 to 10 of about 1,103 (171)

Co-Overexpression of Geissoschizine Synthase and Catharanthine Synthase Increases Catharanthine Biosynthesis in Catharanthus roseus Hairy Roots [PDF]

Plants
Plant-based platforms remain vital for producing anticancer vinca alkaloids. However, one major challenge in plant-based metabolic engineering is that target metabolite yields are often hindered by the presence of multiple competing pathway branches that
Xiaohua Li, Gongqiang Li, Zhiwei Hu, Jiacheng Wang, Yang Chen, Kunhong Zhu, Zichen Huang, Mingyu Wang, Jiayi Sun   +8 more
doaj   +3 more sources

De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces cerevisiae

BioDesign Research, 2022
Vinblastine has been used clinically as one of the most potent therapeutics for the treatment of several types of cancer. However, the traditional plant extraction method suffers from unreliable supply, low abundance, and extremely high cost.
Di Gao, Tengfei Liu, Jucan Gao, Junhao Xu, Yuanwei Gou, Yingjia Pan, Dongfang Li, Cuifang Ye, Ronghui Pan, Lei Huang, Zhinan Xu, Jiazhang Lian   +11 more
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Enhanced accumulation of anticancer compounds in C. roseus hairy root cultures through elicitation and precursor feeding [PDF]

Scientific Reports
Catharanthus roseus is a medicinal plant known for producing numerous indole terpenoid alkaloids. This study investigated the effects of methyl jasmonate, yeast extract, tryptophan, and tryptamine on the accumulation of four key alkaloids—ajmalicine ...
Mohamed R. Rady, Dalia M. Mabrouk, Alaa M. El-Minisy, Mona M. Ibrahim   +3 more
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Catharanthine borane – An unexpected reaction product

Phytochemistry Letters, 2022
International ...
Georges Massiot, Ritchy Leroy, Gautier Bourbon   +2 more
exaly   +3 more sources

UHPLC-QTOF-MS/MS-based metabolomic discovery of anticancer compounds in ethanolic extracts of Ficus hispida L. f. [PDF]

PLoS ONE
Ficus hispida L. f. (F. hispida) is commonly used in traditional medicine for various health problems. No comprehensive analysis of all its components has yet been undertaken, despite researchers having explored its chemical constituents and biological ...
Saengrawee Thammawithan, Jirattiporn Thanuma, Sirinya Sitthirak, Chadapohn Panplu, Thapanee Pruksatrakul, Piya Prajumwongs, Arporn Wangwiwatsin, Poramate Klanrit, Watcharin Loilome, Nisana Namwat   +9 more
doaj   +2 more sources

Genome-wide association studies reveal genetic variants associated with antineoplastic monoterpenoid indole alkaloid accumulation in Catharanthus roseus [PDF]

Frontiers in Plant Science
Catharanthus roseus produces pharmacologically important monoterpenoid indole alkaloids (MIAs), yet their natural accumulation is low, limiting therapeutic exploitation. To dissect the genetic basis of natural variation in MIA accumulation, we integrated
Vyoma Mistry, Seongmin Hong, Seongmin Hong, Chetan Kaur, Gibum Yi, Budhi Sagar Tiwari, Geung-Joo Lee, Geung-Joo Lee, Abhishek Sharma, Abhishek Sharma   +9 more
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Explant origin and growth regulators as determinants of callus performance and terpenoid indole alkaloid accumulation in Catharanthus roseus [PDF]

BMC Plant Biology
Catharanthus roseus (L.) G. Don (Apocynaceae) is a highly important medicinal plant and a valuable source of diverse pharmacologically active compounds particularly anticancer terpenoid indole alkaloids (TIAs), such as catharanthine (CAT), vinblastine ...
Abeer F. Desouky, Salah El-Din El-Assal, Ahmed Abdelsamad, Abdel-Salam Reda, Nancy Danial, Moemen S. Hanafy   +5 more
doaj   +2 more sources

Transcriptomic profiling and oxidative stress responses of Catharanthus roseus under short-term LED light exposure [PDF]

BMC Plant Biology
As the application of LED light on plants is increasing for development of efficient, sustainable, and innovative agricultural strategies, comprehensive knowledge towards response mechanisms of plants under such artificial light source is less known.
Zhuoheng Zhong, Mengmin Wu, Shuang Liang, Zhaohui Luo, Lin Zhang, Hongwei Fu   +5 more
doaj   +2 more sources

Electrospray–Mass Spectrometry-Guided Targeted Isolation of Indole Alkaloids from Leaves of Catharanthus roseus by Using High-Performance Countercurrent Chromatography [PDF]

Molecules
Electrospray mass spectrometry off-line profiling monitored the recovery of targeted indole alkaloids from a fortified crude extract of Catharanthus roseus (790 mg) using semi-preparative high-performance countercurrent chromatography (HPCCC ...
Mahdi Yahyazadeh, Dirk Selmar, Gerold Jerz   +2 more
doaj   +2 more sources

Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation

Marine Drugs, 2022
Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang   +3 more
doaj   +1 more source