De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces cerevisiae [PDF]
BioDesign Research, 2022 Vinblastine has been used clinically as one of the most potent therapeutics for the treatment of several types of cancer. However, the traditional plant extraction method suffers from unreliable supply, low abundance, and extremely high cost.
Di Gao +11 more
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Enhanced accumulation of anticancer compounds in C. roseus hairy root cultures through elicitation and precursor feeding [PDF]
Scientific ReportsCatharanthus roseus is a medicinal plant known for producing numerous indole terpenoid alkaloids. This study investigated the effects of methyl jasmonate, yeast extract, tryptophan, and tryptamine on the accumulation of four key alkaloids—ajmalicine ...
Mohamed R. Rady +2 more
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UHPLC-QTOF-MS/MS-based metabolomic discovery of anticancer compounds in ethanolic extracts of Ficus hispida L. f. [PDF]
PLoS ONEFicus hispida L. f. (F. hispida) is commonly used in traditional medicine for various health problems. No comprehensive analysis of all its components has yet been undertaken, despite researchers having explored its chemical constituents and biological ...
Saengrawee Thammawithan +9 more
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The Enhancement of Catharanthine Content in Catharanthus roseus Callus Culture Treated with Naphtalene Acetic Acid [PDF]
Hayati Journal of Biosciences, 2006 The research aim was to examine the enhancement of catharanthine content in Catharanthus roseus callus culture added with different concentration of Naphtalene Acetic Acid (NAA). NAA treatment produced callus that formed hairy roots. Fresh and dry weight
DINGSE PANDIANGAN, NELSON NAINGGOLAN
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Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast [PDF]
Metabolic Engineering Communications, 2023 With over 3000 reported structures, monoterpenoid indole alkaloids (MIAs) constitute one of the largest alkaloid groups in nature, including the clinically important anticancer drug vinblastine and its semi-synthetic derivatives from Catharanthus roseus (
Mohammadamin Shahsavarani +7 more
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Explant origin and growth regulators as determinants of callus performance and terpenoid indole alkaloid accumulation in Catharanthus roseus [PDF]
BMC Plant BiologyCatharanthus roseus (L.) G. Don (Apocynaceae) is a highly important medicinal plant and a valuable source of diverse pharmacologically active compounds particularly anticancer terpenoid indole alkaloids (TIAs), such as catharanthine (CAT), vinblastine ...
Abeer F. Desouky +5 more
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Transcriptomic profiling and oxidative stress responses of Catharanthus roseus under short-term LED light exposure [PDF]
BMC Plant BiologyAs the application of LED light on plants is increasing for development of efficient, sustainable, and innovative agricultural strategies, comprehensive knowledge towards response mechanisms of plants under such artificial light source is less known.
Zhuoheng Zhong +5 more
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Electrospray–Mass Spectrometry-Guided Targeted Isolation of Indole Alkaloids from Leaves of Catharanthus roseus by Using High-Performance Countercurrent Chromatography [PDF]
MoleculesElectrospray mass spectrometry off-line profiling monitored the recovery of targeted indole alkaloids from a fortified crude extract of Catharanthus roseus (790 mg) using semi-preparative high-performance countercurrent chromatography (HPCCC ...
Mahdi Yahyazadeh +2 more
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Enhancement of vindoline and catharanthine production in Catharanthus roseus by LED light and plasma activated water. [PDF]
PLoS ONEThis study aimed to increase the concentrations of vindoline (VDL) and catharanthine (CAT) in Catharanthus roseus plants cultivated in an indoor farming system using artificial lighting and plasma-activated water (PAW).
Alessandro Quadri +9 more
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Comprehensive analysis of SPL gene family and miR156a/SPLs in the regulation of terpenoid indole alkaloid biosynthesis in Catharanthus roseus L [PDF]
BMC Plant BiologyBackground Catharanthus roseus (C. roseus), belongs to the dogbane family Apocynaceae, is the source of various terpenoid indole alkaloids (TIAs) with excellent antitumor properties, including vinblastine, vincristine, ajmalicine, serpentine, vindoline ...
Yaojie Zhang +9 more
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