Results 31 to 40 of about 1,103 (171)

Exploration of the Mechanisms of Differential Indole Alkaloid Biosynthesis in Dedifferentiated and Cambial Meristematic Cells of Catharanthus roseus Using Transcriptome Sequencing

Frontiers in Genetics, 2022
Catharanthus roseus produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The current research focuses on finding an efficient production system such as cell suspension cultures for high TIA concentrations.
Pengfei Zhou, Mingxiang Chen
doaj   +1 more source

Effect of Aspergillus flavus Fungal Elicitor on the Production of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells

Molecules, 2018
This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by
Chuxin Liang, Chang Chen, Pengfei Zhou, Lv Xu, Jianhua Zhu, Jincai Liang, Jiachen Zi, Rongmin Yu   +7 more
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Preliminary results of indole alkaloids production in different roots of Catharanthus roseus cultured in vitro

Acta Societatis Botanicorum Poloniae, 2014
Six groups of untransformed and hairy root cultures of Catharunthus roseus (L.) G. Don were established. Agrobacterium rhizogenes strains: ATCC 15834, LBA 9403, and TR 105 were used for infection of the 3-week old rooted plantlets of C. roseus.
Agnieszka Pietrosiuk, Mirosława Furmanowa   +1 more
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Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in Nicotiana

Metabolites, 2023
Alkaloids are the most diversified nitrogen-containing secondary metabolites, having antioxidant and antimicrobial properties, and are extensively used in pharmaceuticals to treat different types of cancer.
Md. Ahsan Habib, Md. Mobinul Islam, Md. Mukul Islam, Md. Mohidul Hasan, Kwang-Hyun Baek   +4 more
doaj   +1 more source

Determination of Antiplasmodial Activity and Binding Affinity of Selected Natural Products towards TrxR and GR

Natural Product Communications, 2013
In our study, the binding affinities of selected natural products towards Pf TrxR, Pf GR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay.
Ranjith Munigunti, Katja Becker, Reto Brun, Angela I. Calderón   +3 more
doaj   +1 more source

A cell‐type‐specific regulon controlling monoterpene indole alkaloid biosynthesis with feedback and feedforward activation loops

New Phytologist, Volume 249, Issue 2, Page 945-960, January 2026.
Summary Monoterpene indole alkaloids (MIA) are a diverse class of plant natural products produced by a subset of lineages within the Asterid clade of eudicots. The diversity of MIAs provides a unique opportunity to study not only the evolution of biosynthetic genes but also their regulation.
Chenxin Li, Joshua C. Wood, Brieanne Vaillancourt, John P. Hamilton, Sophia L. Jones, Van‐Hung Bui, Thu‐Thuy T. Dang, C. Robin Buell   +7 more
wiley   +1 more source

Terpene Moiety Enhancement by Overexpression of Geranyl(geranyl) Diphosphate Synthase and Geraniol Synthase Elevates Monomeric and Dimeric Monoterpene Indole Alkaloids in Transgenic Catharanthus roseus

Frontiers in Plant Science, 2018
Catharanthus roseus is the sole source of two of the most important anticancer monoterpene indole alkaloids (MIAs), vinblastine and vincristine and their precursors, vindoline and catharanthine.
Sarma R. Kumar, H. B. Shilpashree, Dinesh A. Nagegowda   +2 more
doaj   +1 more source

Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. [PDF]

PLoS ONE, 2012
In order to improve the production of the anticancer dimeric indole alkaloids in Catharanthuse roseus, much research has been dedicated to culturing cell lines, hairy roots, and efforts to elucidate the regulation of the monoterpenoid indole alkaloid ...
Qifang Pan, Quan Wang, Fang Yuan, Shihai Xing, Jingya Zhao, Young Hae Choi, Robert Verpoorte, Yuesheng Tian, Guofeng Wang, Kexuan Tang   +9 more
doaj   +1 more source

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Molecules, 2021
Plant specialized metabolites are widely used in the pharmaceutical industry, including the monoterpene indole alkaloids (MIAs) vinblastine and vincristine, which both display anticancer activity.
Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc’h, Nicolas Papon, Marc Clastre, Vincent Courdavault   +10 more
doaj   +1 more source

Inhibitory Effects of Enoxolone on Porcine Epidemic Diarrhea Virus In Vitro and In Vivo

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine epidemic diarrhea (PED) is characterized as an acute and highly contagious intestinal ailment induced by the PED virus (PEDV), presenting clinical symptoms such as emesis, diarrhea, and dehydration. The occurrence of PED has imposed a substantial economic burden on the global swine farming industry.
Jie Li, Feixiang Zhu, Han Xu, Hongyue Li, Jiang Jin, Muyu Zhu, Junjie Liu, Jun Wang, Yingchun Zhou, Zongyi Bo, Haixiao Shen, Junfang Yan, Yan Cheng, Xinyue Chang, Xuelan Liu, Xianrui Zheng, Wei Li, Zongjun Yin, Liang Li, Pei Sun, Zhong Peng   +20 more
wiley   +1 more source