Results 31 to 40 of about 1,070 (170)

DNA Binding Studies of Vinca Alkaloids: Experimental and Computational Evidence

Natural Product Communications, 2012
Fluorescence studies on the indole alkaloids vinblastine sulfate, vincristine sulfate, vincamine and catharanthine have demonstrated the DNA binding ability of these molecules.
Prateek Pandya, Surendra P. Gupta, Kumud Pandav, Ritu Barthwal, B. Jayaram, Surat Kumar   +5 more
doaj   +1 more source

Effects of PEG-induced drought stress on regulation of indole alkaloid biosynthesis in Catharanthus roseus

Journal of Plant Interactions, 2017
Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu, Qinghuan Meng, Xihua Duan, Zhonghua Zhang, Dewen Li   +4 more
doaj   +1 more source

Effect of Aspergillus flavus Fungal Elicitor on the Production of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells

Molecules, 2018
This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by
Chuxin Liang, Chang Chen, Pengfei Zhou, Lv Xu, Jianhua Zhu, Jincai Liang, Jiachen Zi, Rongmin Yu   +7 more
doaj   +1 more source

Exploration of the Mechanisms of Differential Indole Alkaloid Biosynthesis in Dedifferentiated and Cambial Meristematic Cells of Catharanthus roseus Using Transcriptome Sequencing

Frontiers in Genetics, 2022
Catharanthus roseus produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The current research focuses on finding an efficient production system such as cell suspension cultures for high TIA concentrations.
Pengfei Zhou, Mingxiang Chen
doaj   +1 more source

Preliminary results of indole alkaloids production in different roots of Catharanthus roseus cultured in vitro

Acta Societatis Botanicorum Poloniae, 2014
Six groups of untransformed and hairy root cultures of Catharunthus roseus (L.) G. Don were established. Agrobacterium rhizogenes strains: ATCC 15834, LBA 9403, and TR 105 were used for infection of the 3-week old rooted plantlets of C. roseus.
Agnieszka Pietrosiuk, Mirosława Furmanowa   +1 more
doaj   +1 more source

Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in Nicotiana

Metabolites, 2023
Alkaloids are the most diversified nitrogen-containing secondary metabolites, having antioxidant and antimicrobial properties, and are extensively used in pharmaceuticals to treat different types of cancer.
Md. Ahsan Habib, Md. Mobinul Islam, Md. Mukul Islam, Md. Mohidul Hasan, Kwang-Hyun Baek   +4 more
doaj   +1 more source

Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. [PDF]

PLoS ONE, 2012
In order to improve the production of the anticancer dimeric indole alkaloids in Catharanthuse roseus, much research has been dedicated to culturing cell lines, hairy roots, and efforts to elucidate the regulation of the monoterpenoid indole alkaloid ...
Qifang Pan, Quan Wang, Fang Yuan, Shihai Xing, Jingya Zhao, Young Hae Choi, Robert Verpoorte, Yuesheng Tian, Guofeng Wang, Kexuan Tang   +9 more
doaj   +1 more source

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Molecules, 2021
Plant specialized metabolites are widely used in the pharmaceutical industry, including the monoterpene indole alkaloids (MIAs) vinblastine and vincristine, which both display anticancer activity.
Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc’h, Nicolas Papon, Marc Clastre, Vincent Courdavault   +10 more
doaj   +1 more source

Determination of Antiplasmodial Activity and Binding Affinity of Selected Natural Products towards TrxR and GR

Natural Product Communications, 2013
In our study, the binding affinities of selected natural products towards Pf TrxR, Pf GR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay.
Ranjith Munigunti, Katja Becker, Reto Brun, Angela I. Calderón   +3 more
doaj   +1 more source

Terpene Moiety Enhancement by Overexpression of Geranyl(geranyl) Diphosphate Synthase and Geraniol Synthase Elevates Monomeric and Dimeric Monoterpene Indole Alkaloids in Transgenic Catharanthus roseus

Frontiers in Plant Science, 2018
Catharanthus roseus is the sole source of two of the most important anticancer monoterpene indole alkaloids (MIAs), vinblastine and vincristine and their precursors, vindoline and catharanthine.
Sarma R. Kumar, H. B. Shilpashree, Dinesh A. Nagegowda   +2 more
doaj   +1 more source