Results 31 to 40 of about 1,989 (164)

Addition of Vindoline to p-Benzoquinone: Regiochemistry, Stereochemistry and Symmetry Considerations

Molecules, 2021
Vindoline and catharanthine are the major alkaloids of Catharanthus roseus and are extracted in large quantities to prepare the pharmaceutically important Vinca type alkaloids vincaleukoblastine, vincristine and navelbine.
Shamsher Ali, Eric Hénon, Ritchy Leroy, Georges Massiot   +3 more
doaj   +1 more source

Polyploidy Induction of Rutaceae through Bio-catharanthine Treatment [PDF]

, 2021
Indonesia has a tropical monsoon-type climate which suitable for agriculture and plantations. One of the main centers of orange fruits (Citrus sp.) production in Indonesia and become the top ten with the largest production is in South Sulawesi.
Alir, Rahmat Fajrin, Amnah, Alifah Zul, Aziz, Isna Rasdianah, Hajrah, Hajrah, Hermawan, Isna Ainun, Mahfut, Mahfut, Mustami, Muhammad Khalifah, Muthiadin, Cut, Suryafly, Fanny Dhea, Upreti, Brij Mohan   +9 more
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Catharanthus roseus (L.) G. Don - plant regeneration and alkaloids content

Acta Societatis Botanicorum Poloniae, 2014
We describe here a regeneration of plantlets of Catharanthus roseus (L.) G. Don from shoot tips and axillary buds. Shoot tips were excised from 7-day-old seedlings and were incubated in solid Nitsch and Nitsch (NN) medium supplemented with kinetin ...
Mirosława Furmanowa, Hanna Olędzka, Joanna Józefowicz, Agnieszka Pietrosiuk   +3 more
doaj   +1 more source

Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"? [PDF]

, 2010
Background The first two enzymatic steps of monoterpene indole alkaloid (MIA) biosynthetic pathway are catalysed by strictosidine synthase (STR) that condensates tryptamine and secologanin to form strictosidine and by strictosidine β-D-glucosidase (SGD ...
Guirimand Grégory, Courdavault Vincent, Lanoue Arnaud, Mahroug Samira, Guihur Anthony, Blanc Nathalie, Giglioli-Guivarc'h Nathalie, St-Pierre Benoit, Burlat Vincent   +8 more
core   +1 more source

Cell type matters : competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]

, 2023
Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko, Hildebrandt, Sarah Lea, Keller, Judith, L-Raorane, Manish, Manz, Christina, Mielke, Marion, Nick, Peter, Thieme, Marc   +7 more
core   +1 more source

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D., Porco, John A., Stephenson, Corey R.J.   +2 more
core   +2 more sources

A Simplified Procedure for Indole Alkaloid Extraction from Catharanthus roseus Combined with a Semi-synthetic Production Process for Vinblastine

Molecules, 2007
Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola, Aarre Huhtikangas, Tuulikki Seppänen-Laakso, Into Laakso, Arvind Verma   +4 more
doaj   +1 more source

Eliciting Effect of Catharanthine on the Biosynthesis of Vallesiachotamine and Isovallesiachotamine in Cambial Meristematic Cells

Natural Product Communications, 2018
Vallesiachotamine and isovallesiachotamine are pharmacologically active monoterpene indole alkaloids produced by Catharanthus roseus . However, the biosynthetic pathway for these two alkaloids has not been characterized.
Jianhua Zhu, Shuijie He, Pengfei Zhou, Jiachen Zi, Jincai Liang, Liyan Song, Rongmin Yu   +6 more
doaj   +1 more source

A microbial supply chain for production of the anti-cancer drug vinblastine [PDF]

, 2022
International audienceAbstract Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine 1 .
Adhikari, K., Arsovska, D., Baidoo, E., Carrasquer-Alvarez, E., Chan, L., Chen, L., Christensen, H., Courdavault, V., D’Ambrosio, V., Giannakou, K., Gudich, O., Haidar, A., Hansen, L., Jensen, M., Jørgensen, M., Keasling, J., Kristensen, M., Laloux, M., Lassen, L., Lehka, B., Nallapareddy, S., O’Connor, S., Petzold, C., Rubaszka, P., Schrübbers, L., Stander, E., Sudarsan, S., Viehrig, K., Wulff, T., Zhang, J.   +29 more
core   +2 more sources

Virtual Screening of Alkaloid and Terpenoid Inhibitors of SMT Expressed in Naegleria sp.

Molecules, 2022
The pathogenic form of thermophilic Naegleria sp. i.e., Naegleria fowleri, also known as brain eating amoeba, causes primary amoebic encephalitis (PAM) with a >97% fatality rate.
Jason Abraham, Neha Chauhan, Supriyo Ray
doaj   +1 more source