Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]
Plant Biotechnol JABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B +9 more
europepmc +2 more sources
Second-Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules. [PDF]
Angew Chem Int Ed EnglThe second‐generation crystalline sponge method allows structurally diverse molecular guests to crystallize under standardized crystallization conditions. The key is the predominant packing type of cages and anions in crystals. ABSTRACT Crystallization is typically highly sensitive to even minor structural differences in target molecules.
He W, Takezawa H, Fujita M.
europepmc +2 more sources
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop [PDF]
Biochemical Pharmacology, 2022 Cecilia M Borghese +2 more
exaly +3 more sources
Assembly and analysis of stephania japonica mitochondrial genome provides new insights into its identification and energy metabolism [PDF]
BMC GenomicsStephania japonica, a popular indoor ornamental and medicinal plant widely found in southern China, contains many natural compounds with potential medicinal value. S.
Ya Wu +6 more
doaj +2 more sources
Transcriptional Reprogramming Deploys a Compartmentalized 'Timebomb' in Catharanthus roseus to Fend Off Chewing Herbivores. [PDF]
Plant Cell EnvironABSTRACT The evolutionary arms race between plants and insects has led to key adaptive innovations that drive diversification. Alkaloids are well‐documented anti‐herbivory compounds in plant chemical defences, but how these specialized metabolites are allocated to cope with both biotic and abiotic stresses concomitantly is largely unknown.
Liu Y +11 more
europepmc +2 more sources
Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in Nicotiana benthamiana. [PDF]
ACS Synth Biol, 2023 Grzech D +4 more
europepmc +3 more sources
Marine Drugs, 2022 Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang +3 more
doaj +1 more source
Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters [PDF]
ACS Chemical NeuroscienceGavin C Jones +2 more
exaly +2 more sources
Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids. [PDF]
European J Org ChemThe iboga alkaloid class of monoterpene indole alkaloids have long inspired synthetic chemists in their structural complexity and dense functionalization. Their unique anti‐addictive properties have propelled this class of natural products into potential lead compounds for drug discovery efforts as well.
Hughes AJ, Hamelink CR, Townsend SD.
europepmc +2 more sources
Frontiers in Plant Science, 2023 NAC transcription factors (TFs) are crucial to growth and defense responses in plants. Though NACs have been characterized for their role in several plants, comprehensive information regarding their role in Catharanthus roseus, a perennial ornamental ...
Jawad Ahmed +9 more
doaj +1 more source