Results 11 to 20 of about 1,070 (170)

Second-Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules. [PDF]

Angew Chem Int Ed Engl
The second‐generation crystalline sponge method allows structurally diverse molecular guests to crystallize under standardized crystallization conditions. The key is the predominant packing type of cages and anions in crystals. ABSTRACT Crystallization is typically highly sensitive to even minor structural differences in target molecules.
He W, Takezawa H, Fujita M.
europepmc   +3 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Transcriptional Reprogramming Deploys a Compartmentalized 'Timebomb' in Catharanthus roseus to Fend Off Chewing Herbivores. [PDF]

Plant Cell Environ
ABSTRACT The evolutionary arms race between plants and insects has led to key adaptive innovations that drive diversification. Alkaloids are well‐documented anti‐herbivory compounds in plant chemical defences, but how these specialized metabolites are allocated to cope with both biotic and abiotic stresses concomitantly is largely unknown.
Liu Y, Shi J, Patra B, Singh SK, Wu X, Lyu R, Liu X, Li Y, Wang Y, Zhou X, Pattanaik S, Yuan L.   +11 more
europepmc   +2 more sources

Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation

Marine Drugs, 2022
Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang, Xiaoqi Liu, Yuning He, Fan Yang   +3 more
doaj   +1 more source

Genome-wide identification of NAC transcription factors and regulation of monoterpenoid indole alkaloid biosynthesis in Catharanthus roseus

Frontiers in Plant Science, 2023
NAC transcription factors (TFs) are crucial to growth and defense responses in plants. Though NACs have been characterized for their role in several plants, comprehensive information regarding their role in Catharanthus roseus, a perennial ornamental ...
Jawad Ahmed, Jawad Ahmed, Yasar Sajjad, Mansour K. Gatasheh, Khalid Elfaki Ibrahim, Muhammad Huzafa, Sabaz Ali Khan, Chen Situ, Arshad Mehmood Abbasi, Amjad Hassan   +9 more
doaj   +1 more source

Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast

Metabolic Engineering Communications, 2023
With over 3000 reported structures, monoterpenoid indole alkaloids (MIAs) constitute one of the largest alkaloid groups in nature, including the clinically important anticancer drug vinblastine and its semi-synthetic derivatives from Catharanthus roseus (
Mohammadamin Shahsavarani, Joseph Christian Utomo, Rahul Kumar, Melina Paz-Galeano, Jorge Jonathan Oswaldo Garza-García, Zhan Mai, Dae-Kyun Ro, Yang Qu   +7 more
doaj   +1 more source

Bioproduction of monoterpene indole alkaloids in a single cell factory

Engineering Microbiology, 2022
The de novo biosynthesis of vindoline and catharanthine, the direct precursors used for industrial production of the anti-cancer drug vinblastine, has been achieved in the yeast cell factory.
Jianping Huang, Shengxiong Huang
doaj   +1 more source

Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids. [PDF]

European J Org Chem
The iboga alkaloid class of monoterpene indole alkaloids have long inspired synthetic chemists in their structural complexity and dense functionalization. Their unique anti‐addictive properties have propelled this class of natural products into potential lead compounds for drug discovery efforts as well.
Hughes AJ, Hamelink CR, Townsend SD.
europepmc   +2 more sources

Genome-wide identification and expression analysis of TCP family genes in Catharanthus roseus

Frontiers in Plant Science, 2023
IntroductionThe anti-tumor vindoline and catharanthine alkaloids are naturally existed in Catharanthus roseus (C. roseus), an ornamental plant in many tropical countries.
Juan Hao, Juan Hao, Lijun Zheng, Lijun Zheng, Yidie Han, Yidie Han, Hongshan Zhang, Hongshan Zhang, Hongshan Zhang, Kailin Hou, Kailin Hou, Xueshuang Liang, Xueshuang Liang, Cheng Chen, Zhijing Wang, Jiayi Qian, Jiayi Qian, Zhihao Lin, Zhihao Lin, Zitong Wang, Houqing Zeng, Houqing Zeng, Chenjia Shen, Chenjia Shen, Chenjia Shen   +24 more
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Peningkatan Kandungan Katarantin pada Kultur Kalus Catharanthus roseus dengan Pemberian Naphtalene Acetic Acid

Hayati Journal of Biosciences, 2006
The research aim was to examine the enhancement of catharanthine content in Catharanthus roseus callus culture added with different concentration of Naphtalene Acetic Acid (NAA). NAA treatment produced callus that formed hairy roots. Fresh and dry weight
DINGSE PANDIANGAN, NELSON NAINGGOLAN
doaj   +1 more source