Results 21 to 30 of about 1,103 (171)
Molecules, 2023 Catharanthus roseus is a medicinal plant that produces indole alkaloids, which are utilized in anticancer therapy. Vinblastine and vincristine, two commercially important antineoplastic alkaloids, are mostly found in the leaves of Catharanthus roseus.
Hossam S. El-Beltagi +11 more
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Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings
Molecules, 2018 Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich +8 more
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Catharanthus roseus (L.) G. Don - plant regeneration and alkaloids content
Acta Societatis Botanicorum Poloniae, 2014 We describe here a regeneration of plantlets of Catharanthus roseus (L.) G. Don from shoot tips and axillary buds. Shoot tips were excised from 7-day-old seedlings and were incubated in solid Nitsch and Nitsch (NN) medium supplemented with kinetin ...
Mirosława Furmanowa +3 more
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Addition of Vindoline to p-Benzoquinone: Regiochemistry, Stereochemistry and Symmetry Considerations
Molecules, 2021 Vindoline and catharanthine are the major alkaloids of Catharanthus roseus and are extracted in large quantities to prepare the pharmaceutically important Vinca type alkaloids vincaleukoblastine, vincristine and navelbine.
Shamsher Ali +3 more
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Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids. [PDF]
European J Org ChemThe iboga alkaloid class of monoterpene indole alkaloids have long inspired synthetic chemists in their structural complexity and dense functionalization. Their unique anti‐addictive properties have propelled this class of natural products into potential lead compounds for drug discovery efforts as well.
Hughes AJ, Hamelink CR, Townsend SD.
europepmc +2 more sources
Molecules, 2007 Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola +4 more
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Natural Product Communications, 2018 Vallesiachotamine and isovallesiachotamine are pharmacologically active monoterpene indole alkaloids produced by Catharanthus roseus . However, the biosynthetic pathway for these two alkaloids has not been characterized.
Jianhua Zhu +6 more
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Virtual Screening of Alkaloid and Terpenoid Inhibitors of SMT Expressed in Naegleria sp.
Molecules, 2022 The pathogenic form of thermophilic Naegleria sp. i.e., Naegleria fowleri, also known as brain eating amoeba, causes primary amoebic encephalitis (PAM) with a >97% fatality rate.
Jason Abraham, Neha Chauhan, Supriyo Ray
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DNA Binding Studies of Vinca Alkaloids: Experimental and Computational Evidence
Natural Product Communications, 2012 Fluorescence studies on the indole alkaloids vinblastine sulfate, vincristine sulfate, vincamine and catharanthine have demonstrated the DNA binding ability of these molecules.
Prateek Pandya +5 more
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Journal of Plant Interactions, 2017 Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu +4 more
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