Results 21 to 30 of about 1,989 (164)

Bioproduction of monoterpene indole alkaloids in a single cell factory

Engineering Microbiology, 2022
The de novo biosynthesis of vindoline and catharanthine, the direct precursors used for industrial production of the anti-cancer drug vinblastine, has been achieved in the yeast cell factory.
Jianping Huang, Shengxiong Huang
doaj   +1 more source

Genome-wide identification and expression analysis of TCP family genes in Catharanthus roseus

Frontiers in Plant Science, 2023
IntroductionThe anti-tumor vindoline and catharanthine alkaloids are naturally existed in Catharanthus roseus (C. roseus), an ornamental plant in many tropical countries.
Juan Hao, Juan Hao, Lijun Zheng, Lijun Zheng, Yidie Han, Yidie Han, Hongshan Zhang, Hongshan Zhang, Hongshan Zhang, Kailin Hou, Kailin Hou, Xueshuang Liang, Xueshuang Liang, Cheng Chen, Zhijing Wang, Jiayi Qian, Jiayi Qian, Zhihao Lin, Zhihao Lin, Zitong Wang, Houqing Zeng, Houqing Zeng, Chenjia Shen, Chenjia Shen, Chenjia Shen   +24 more
doaj   +1 more source

Stereochemical insights into sarpagan and akuammiline alkaloid biosynthesis. [PDF]

New Phytol
Summary Sarpagan and akuammiline monoterpenoid indole alkaloids (MIAs) are a class of bioactive plant‐derived compounds with significant pharmaceutical potential. These alkaloids are formed through oxidative cyclization of geissoschizine, catalyzed by homologous cytochrome P450 monooxygenases (CYP) known as sarpagan bridge enzymes (SBEs) and rhazimal ...
Mann SGA, Paz-Galeano M, Shahsavarani M, Perley JO, Guo J, Garza-Garcia JJO, Qu Y.   +6 more
europepmc   +2 more sources

Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan

Molecules, 2023
Catharanthus roseus is a medicinal plant that produces indole alkaloids, which are utilized in anticancer therapy. Vinblastine and vincristine, two commercially important antineoplastic alkaloids, are mostly found in the leaves of Catharanthus roseus.
Hossam S. El-Beltagi, Salwa M. El-Sayed, Ahmed. N. Abdelhamid, Karim. M. Hassan, Walaa. A. Elshalakany, Mona Ibrahim Nossier, Nadiyah M. Alabdallah, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Doaa Bahaa Eldin Darwish, Zahid Khorshid Abbas, Hemmat A. Ibrahim   +11 more
doaj   +1 more source

Peningkatan Kandungan Katarantin pada Kultur Kalus Catharanthus roseus dengan Pemberian Naphtalene Acetic Acid

Hayati Journal of Biosciences, 2006
The research aim was to examine the enhancement of catharanthine content in Catharanthus roseus callus culture added with different concentration of Naphtalene Acetic Acid (NAA). NAA treatment produced callus that formed hairy roots. Fresh and dry weight
DINGSE PANDIANGAN, NELSON NAINGGOLAN
doaj   +1 more source

UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures

BMC Plant Biology, 2007
Background Elicitations are considered to be an important strategy towards improved in vitro production of secondary metabolites. In cell cultures, biotic and abiotic elicitors have effectively stimulated the production of plant secondary metabolites ...
Chelliah Jayabaskaran, Ramani Shilpa
doaj   +1 more source

The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway [PDF]

, 2013
Background: The terpenoid indole alkaloid (TIA) pathway leads to the production of pharmaceutically important drugs, such as the anticancer compounds vinblastine and vincristine.
Gibson, Susan, Leopold, Alex, Li, Chun, Sander, Guy, Shanks, Jacqueline, Shanks, Jacqueline, Zhao, Le   +6 more
core   +3 more sources

Spatial transcriptomics drives a new era in plant research

The Plant Journal, Volume 116, Issue 6, Page 1571-1581, December 2023., 2023
SUMMARY The plant community lags far behind the animal and human fields concerning the application of single‐cell methodologies. This is primarily due to the challenges associated with plant tissue dissection and the limitations of the available technologies.
Ruilian Yin, Keke Xia, Xun Xu
wiley   +1 more source

Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings

Molecules, 2018
Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich, Szabolcs Mayer, Réka Pápai, Áron Szigetvári, Zsuzsanna Sánta, Miklós Dékány, Csaba Szántay, Péter Keglevich, László Hazai   +8 more
doaj   +1 more source

Synthetic Modulation of an Unstable Dehydrosecodine‐type Intermediate and Its Encapsulation into a Confined Cavity Enable Its X‐ray Crystallographic Observation

Angewandte Chemie, Volume 135, Issue 32, August 7, 2023., 2023
The X‐ray crystallographic analysis of a labile dehydrosecodine‐type intermediate was achieved by designing a functionally modulated analogue, enabling its inclusion within a self‐assembled coordination cage. The unique folded conformation of this intermediate, stabilized inside the hydrophobic cavity, was supported by DFT calculations and supports the
Gavin Tay, Toshiaki Wayama, Hiroki Takezawa, Satoshi Yoshida, Sota Sato, Makoto Fujita, Hiroki Oguri   +6 more
wiley   +1 more source