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New Phytologist, Volume 249, Issue 2, Page 945-960, January 2026.Summary Monoterpene indole alkaloids (MIA) are a diverse class of plant natural products produced by a subset of lineages within the Asterid clade of eudicots. The diversity of MIAs provides a unique opportunity to study not only the evolution of biosynthetic genes but also their regulation.
Chenxin Li +7 more
wiley +1 more source
Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)
Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni +5 more
wiley +1 more source
Hayati Journal of Biosciences, 2006 The research aim was to examine the enhancement of catharanthine content in Catharanthus roseus callus culture added with different concentration of Naphtalene Acetic Acid (NAA). NAA treatment produced callus that formed hairy roots. Fresh and dry weight
DINGSE PANDIANGAN, NELSON NAINGGOLAN
doaj
Plants, 2022 Catharanthus roseus synthesizes bioactive therapeutic metabolites, known as monoterpenoid indole alkaloids (MIAs), including antineoplastic vinblastine and vincristine, which have high global demand, and antihypertensive ajmalicine, a serpentine. However,
Vyoma Mistry +5 more
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Novel Biocatalysts from Specialized Metabolism
Angewandte Chemie, Volume 136, Issue 4, January 22, 2024.Enzymes are increasingly valuable as biocatalysts in synthetic chemistry. Many novel biocatalysts have emerged from the study of secondary metabolism, where rare and unusual reactions take place. In this review, we explore biocatalysts that address various synthetic challenges, including cyclization, C−H functionalization, and cross‐coupling, among ...
Hajo Kries +2 more
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Molecules, 2012 In the present study, an improved method termed negative-pressure cavitation extraction (NPCE) followed by reverse phase high-performance liquid chromatography (RP-HPLC) was developed for the extraction and quantification of vindoline (VDL ...
Yuangang Zu +6 more
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Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis
ChemistryEurope, Volume 3, Issue 4, July 14, 2025.This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley +1 more source
Do Fungicides Affect Alkaloid Production in Catharanthus roseus (L.) G. Don. Seedlings?
Molecules, 2023 The presence of endophytes in plants is undeniable, but how significant their involvement is in the host plant biosynthetic pathways is still unclear. The results reported from fungicide treatments in plants varied. Fungicide treatment in Taxus was found
Purin Candra Purnama +2 more
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PlantsPlant-based platforms remain vital for producing anticancer vinca alkaloids. However, one major challenge in plant-based metabolic engineering is that target metabolite yields are often hindered by the presence of multiple competing pathway branches that
Xiaohua Li +8 more
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Binary Stress Induces an Increase in Indole Alkaloid Biosynthesis in Catharanthus roseus
Frontiers in Plant Science, 2015 Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis
Wei eZhu +5 more
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