Results 41 to 50 of about 1,359 (207)

Effect of Aspergillus flavus Fungal Elicitor on the Production of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells

Molecules, 2018
This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by
Chuxin Liang, Chang Chen, Pengfei Zhou, Lv Xu, Jianhua Zhu, Jincai Liang, Jiachen Zi, Rongmin Yu   +7 more
doaj   +1 more source

Stereocontrolled Total Synthesis of (±)-Catharanthine via Radical-Mediated Indole Formation

, 2016
A stereocontrolled total synthesis of (±)-catharanthine, 1, has been completed. The key step involves the radical-mediated cyclization of a highly functionalized intermediate to furnish the corresponding indole.
Tohru Fukuyama (1508317), Matthew T. Reding (2996823)   +1 more
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Enantioselective Formal Synthesis of (-)-Catharanthine through Enzyme-Catalyzed Desymmetrization of a meso -Azabicyclo [2.2.2]octane

, 2023
Ikeda K, Harada S, Hashimoto Y, et al. Enantioselective Formal Synthesis of (-)-Catharanthine through Enzyme-Catalyzed Desymmetrization of a meso -Azabicyclo [2.2.2]octane. Synlett.
Hashimoto, Yoshinori, Gröger, Harald, Homma, Haruka, Kono, Masato, Harada, Shingo, Ikeda, Kotaro, Zumbrägel, Nadine ; https://orcid.org/, Nemoto, Tetsuhiro   +7 more
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Preliminary results of indole alkaloids production in different roots of Catharanthus roseus cultured in vitro

Acta Societatis Botanicorum Poloniae, 2014
Six groups of untransformed and hairy root cultures of Catharunthus roseus (L.) G. Don were established. Agrobacterium rhizogenes strains: ATCC 15834, LBA 9403, and TR 105 were used for infection of the 3-week old rooted plantlets of C. roseus.
Agnieszka Pietrosiuk, Mirosława Furmanowa   +1 more
doaj   +1 more source

Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in Nicotiana

Metabolites, 2023
Alkaloids are the most diversified nitrogen-containing secondary metabolites, having antioxidant and antimicrobial properties, and are extensively used in pharmaceuticals to treat different types of cancer.
Md. Ahsan Habib, Md. Mobinul Islam, Md. Mukul Islam, Md. Mohidul Hasan, Kwang-Hyun Baek   +4 more
doaj   +1 more source

Determination of Antiplasmodial Activity and Binding Affinity of Selected Natural Products towards TrxR and GR

Natural Product Communications, 2013
In our study, the binding affinities of selected natural products towards Pf TrxR, Pf GR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay.
Ranjith Munigunti, Katja Becker, Reto Brun, Angela I. Calderón   +3 more
doaj   +1 more source

Catharanthine Modulates Mesolimbic Dopamine Transmission: A Potential Treatment for Alcohol Use Disorder

, 2022
Catharanthine is derived from the Catharanthus roseus plant and is an analog to ibogaine, a drug that reduces opioid and alcohol withdrawal symptoms and decreases drug self-administration in both animals and humans.
Williams, Benjamin M.
core  

Terpene Moiety Enhancement by Overexpression of Geranyl(geranyl) Diphosphate Synthase and Geraniol Synthase Elevates Monomeric and Dimeric Monoterpene Indole Alkaloids in Transgenic Catharanthus roseus

Frontiers in Plant Science, 2018
Catharanthus roseus is the sole source of two of the most important anticancer monoterpene indole alkaloids (MIAs), vinblastine and vincristine and their precursors, vindoline and catharanthine.
Sarma R. Kumar, H. B. Shilpashree, Dinesh A. Nagegowda   +2 more
doaj   +1 more source

Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. [PDF]

PLoS ONE, 2012
In order to improve the production of the anticancer dimeric indole alkaloids in Catharanthuse roseus, much research has been dedicated to culturing cell lines, hairy roots, and efforts to elucidate the regulation of the monoterpenoid indole alkaloid ...
Qifang Pan, Quan Wang, Fang Yuan, Shihai Xing, Jingya Zhao, Young Hae Choi, Robert Verpoorte, Yuesheng Tian, Guofeng Wang, Kexuan Tang   +9 more
doaj   +1 more source

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Molecules, 2021
Plant specialized metabolites are widely used in the pharmaceutical industry, including the monoterpene indole alkaloids (MIAs) vinblastine and vincristine, which both display anticancer activity.
Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc’h, Nicolas Papon, Marc Clastre, Vincent Courdavault   +10 more
doaj   +1 more source