Results 41 to 50 of about 1,989 (164)

Involvement of the leaf-specific multidrug and toxic compound extrusion (MATE) transporter Nt-JAT2 in vacuolar sequestration of nicotine in Nicotiana tabacum [PDF]

, 2014
Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of Nicotiana species, is translocated via xylem transport toward the accumulation sites, leaf ...
Goossens, Alain, Hayashida, Minaho, Ito, Shingo, Minami, Shota, Morita, Masahiko, Moriyama, Yoshinori, Moriyasu, Masataka, Omote, Hiroshi, Shitan, Nobukazu, Sugiyama, Akifumi, Takanashi, Kojiro, Yazaki, Kazufumi   +11 more
core   +4 more sources

Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]

, 2022
Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko, Hildebrandt, Sarah, Keller, Judith, Manz, Christina, Mielke, Marion, Nick, Peter, Raorane, Manish L., Thieme, Marc   +7 more
core   +2 more sources

DNA Binding Studies of Vinca Alkaloids: Experimental and Computational Evidence

Natural Product Communications, 2012
Fluorescence studies on the indole alkaloids vinblastine sulfate, vincristine sulfate, vincamine and catharanthine have demonstrated the DNA binding ability of these molecules.
Prateek Pandya, Surendra P. Gupta, Kumud Pandav, Ritu Barthwal, B. Jayaram, Surat Kumar   +5 more
doaj   +1 more source

Exploration of the Mechanisms of Differential Indole Alkaloid Biosynthesis in Dedifferentiated and Cambial Meristematic Cells of Catharanthus roseus Using Transcriptome Sequencing

Frontiers in Genetics, 2022
Catharanthus roseus produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The current research focuses on finding an efficient production system such as cell suspension cultures for high TIA concentrations.
Pengfei Zhou, Mingxiang Chen
doaj   +1 more source

Vinorelbine with or without Trastuzumab in Metastatic Breast Cancer: A Retrospective Single Institution Series [PDF]

, 2014
Background. We report our experience with vinorelbine, a widely used chemotherapeutic, in unselected metastatic breast cancer patients treated in clinical routine. Patients and Methods.
Stravodimou, A., Voutsadakis, I.A., Zaman, K.   +2 more
core   +4 more sources

Effects of PEG-induced drought stress on regulation of indole alkaloid biosynthesis in Catharanthus roseus

Journal of Plant Interactions, 2017
Catharanthus roseus (C. roseus) plants were used to investigate the terpenoid indole alkaloids (TIAs) accumulation under the condition of PEG-induced drought stress.
Ying Liu, Qinghuan Meng, Xihua Duan, Zhonghua Zhang, Dewen Li   +4 more
doaj   +1 more source

Effect of Aspergillus flavus Fungal Elicitor on the Production of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells

Molecules, 2018
This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by
Chuxin Liang, Chang Chen, Pengfei Zhou, Lv Xu, Jianhua Zhu, Jincai Liang, Jiachen Zi, Rongmin Yu   +7 more
doaj   +1 more source

Preliminary results of indole alkaloids production in different roots of Catharanthus roseus cultured in vitro

Acta Societatis Botanicorum Poloniae, 2014
Six groups of untransformed and hairy root cultures of Catharunthus roseus (L.) G. Don were established. Agrobacterium rhizogenes strains: ATCC 15834, LBA 9403, and TR 105 were used for infection of the 3-week old rooted plantlets of C. roseus.
Agnieszka Pietrosiuk, Mirosława Furmanowa   +1 more
doaj   +1 more source

Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in Nicotiana

Metabolites, 2023
Alkaloids are the most diversified nitrogen-containing secondary metabolites, having antioxidant and antimicrobial properties, and are extensively used in pharmaceuticals to treat different types of cancer.
Md. Ahsan Habib, Md. Mobinul Islam, Md. Mukul Islam, Md. Mohidul Hasan, Kwang-Hyun Baek   +4 more
doaj   +1 more source

Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis [PDF]

, 2014
In the canon of reactions available to the organic chemist engaged in total synthesis, the Diels–Alder reaction is among the most powerful and well understood. Its ability to rapidly generate molecular complexity through the simultaneous formation of two
Albrecht, Alder, Allred, Arth, Arth, Banville, Barborak, Barcan, Benfey, Berson, Beyler, Beyler, Birch, Birch, Bliese, Blouin, Boezio, Boisvert, Botha, Brener, Brieger, Brogden, Brubaker, Bruce, Bryskier, Butenandt, Cassayre, Chen, Chu-Moyer, Cole, Comini, Corey, Corey, Courchesne, Danishefsky, Davies, Davies, Davies, Dickinson, Diels, Eaton, Eaton, Eaton, Fernández, Fieser, Fleming, Forman, Fu, Gates, Gates, Gates, Gates, Gates, Grieco, Grunwell, Gulland, Gulland, Harrowven, Heckrodt, Heckrodt, Heusler, Hu, Hudlický, Ichihara, Iio, Inubushi, Johns, Kagan, Karlsson, Kende, Kim, Kishi, Kishi, Kishi, Kishi, Kishi, Konno, Kozmin, Kreis, Kummer, Kuttruff, Lang, Layton, Lee, Lukes, Lukes, Magnus, Majetich, Majetich, Marsault, Mehta, Mehta, Mikami, Morales, Mulzer, Nagaoka, Nawrat, Nawrat, Nawrat, Nicolaou, Nicolaou, Nicolaou, Nicolaou, Núñez Montoya, O’Brien, Paquette, Parvez, Pearlman, Perri, Pettit, Podlesny, Podlesny, Poos, Poos, Poos, Presset, Rajapaksa, Rasapalli, Rasapalli, Robinson, Roche, Rodríguez, Rodríguez, Rodríguez, Rodríguez, Rodríguez, Roush, Ruzicka, Sallay, Sarett, Sarett, Sarett, Savard, Sha, Shen, Singh, Smith, Snyder, Speziale, Stork, Stork, Stork, Todd, Trost, Uesaka, von Euler, Waizumi, White, Woodward, Woodward, Woodward, Woodward, Woodward, Woodward, Yamada, Yamaguchi, Yar, Yates, Zanoni, Zincke   +159 more
core   +2 more sources