Results 51 to 60 of about 1,989 (164)

General synthesis of substituted 1,2-dihydropyridines [PDF]

open access: yes, 2016
A general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp3 position is described.
Cotos, Leandro   +3 more
core   +2 more sources

Determination of Antiplasmodial Activity and Binding Affinity of Selected Natural Products towards TrxR and GR

open access: yesNatural Product Communications, 2013
In our study, the binding affinities of selected natural products towards Pf TrxR, Pf GR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay.
Ranjith Munigunti   +3 more
doaj   +1 more source

Terpene Moiety Enhancement by Overexpression of Geranyl(geranyl) Diphosphate Synthase and Geraniol Synthase Elevates Monomeric and Dimeric Monoterpene Indole Alkaloids in Transgenic Catharanthus roseus

open access: yesFrontiers in Plant Science, 2018
Catharanthus roseus is the sole source of two of the most important anticancer monoterpene indole alkaloids (MIAs), vinblastine and vincristine and their precursors, vindoline and catharanthine.
Sarma R. Kumar   +2 more
doaj   +1 more source

Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics. [PDF]

open access: yesPLoS ONE, 2012
In order to improve the production of the anticancer dimeric indole alkaloids in Catharanthuse roseus, much research has been dedicated to culturing cell lines, hairy roots, and efforts to elucidate the regulation of the monoterpenoid indole alkaloid ...
Qifang Pan   +9 more
doaj   +1 more source

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

open access: yesMolecules, 2021
Plant specialized metabolites are widely used in the pharmaceutical industry, including the monoterpene indole alkaloids (MIAs) vinblastine and vincristine, which both display anticancer activity.
Pamela Lemos Cruz   +10 more
doaj   +1 more source

WRKY Transcription Factors: Molecular Regulation and Stress Responses in Plants [PDF]

open access: yes, 2016
Plants in their natural habitat have to face multiple stresses simultaneously. Evolutionary adaptation of developmental, physiological and biochemical parameters give advantage over a single window of stress but not multiple.
Gajendra S. Jeena   +2 more
core   +3 more sources

A cell‐type‐specific regulon controlling monoterpene indole alkaloid biosynthesis with feedback and feedforward activation loops

open access: yesNew Phytologist, Volume 249, Issue 2, Page 945-960, January 2026.
Summary Monoterpene indole alkaloids (MIA) are a diverse class of plant natural products produced by a subset of lineages within the Asterid clade of eudicots. The diversity of MIAs provides a unique opportunity to study not only the evolution of biosynthetic genes but also their regulation.
Chenxin Li   +7 more
wiley   +1 more source

Peningkatan Produksi Katarantin melalui Teknik Elisitasi pada Kultur Agregat Sel Catharanthus Roseus [PDF]

open access: yes, 2011
Penelitian ini bertujuan untuk optimasi dan peningkatan produksi antikanker katarantin khususnya elisitasi. Tujuan praktisnya adalah untuk mengetahui pertumbuhan kalus agregat sel C. roseus yang diberi elisitor, menemukan kurva tumbuh S.
Pandiangan, D. (Dingse)
core  

The regulatory mechanism of fungal elicitor-induced secondary metabolite biosynthesis in medical plants. [PDF]

open access: yes
A wide range of external stress stimuli trigger plant cells to undergo complex network of reactions that ultimately lead to the synthesis and accumulation of secondary metabolites.
Cheng-jian Zheng   +23 more
core   +1 more source

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)

open access: yesChemistry &Biodiversity, Volume 22, Issue 8, August 2025.
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni   +5 more
wiley   +1 more source

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