Results 51 to 60 of about 1,103 (171)

Cell‐type‐aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus

New Phytologist, Volume 245, Issue 1, Page 347-362, January 2025.
Summary In plants, the biosynthetic pathways of some specialized metabolites are partitioned into specialized or rare cell types, as exemplified by the monoterpenoid indole alkaloid (MIA) pathway of Catharanthus roseus (Madagascar Periwinkle), the source of the anticancer compounds vinblastine and vincristine. In the leaf, the C.
Chenxin Li, Maite Colinas, Joshua C. Wood, Brieanne Vaillancourt, John P. Hamilton, Sophia L. Jones, Lorenzo Caputi, Sarah E. O'Connor, C. Robin Buell   +8 more
wiley   +1 more source

Artemisinic Acid Serves as a Novel Inducer to Enhance Biosynthesis of Terpenoid Indole Alkaloids in Cambial Meristematic Cells

Natural Product Communications, 2016
To investigate the effect of artemisinic acid (AA) on improving the production of terpenoid indole alkaloids (TIAs) of Catharanthus roseus cambial meristematic cells (CMCs), feeding AA to C.
Mingxuan Wang, Jiachen Zi, Jianhua Zhu, Shan Chen, Pu Wang, Liyan Song, Rongmin Yu   +6 more
doaj   +1 more source

Genome‐based discovery of pachysiphine synthases in Tabernaemontana elegans

The Plant Journal, Volume 120, Issue 5, Page 1880-1900, December 2024.
Significance Statement While pachysiphine is a monoterpene indole alkaloid of high interest and the precursor of an anti‐Alzheimer compound, its biosynthesis involving the epoxidation of tabersonine remains uncharacterized. By sequencing and assembling the genome of Tabernaemontana elegans, we identified two P450s exhibiting a pachysiphine synthase ...
Enzo Lezin, Mickael Durand, Caroline Birer Williams, Ana Luisa Lopez Vazquez, Thomas Perrot, Nicolas Gautron, Julien Pétrignet, Clément Cuello, Hans J. Jansen, Florent Magot, Sarah Szwarc, Pierre Le Pogam, Mehdi A. Beniddir, Konstantinos Koudounas, Audrey Oudin, Benoit St‐Pierre, Nathalie Giglioli‐Guivarc'h, Chao Sun, Nicolas Papon, Michael Krogh Jensen, Ron P. Dirks, Sarah E. O'Connor, Sébastien Besseau, Vincent Courdavault   +23 more
wiley   +1 more source

Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis

The Plant Journal, Volume 120, Issue 6, Page 2770-2783, December 2024.
SUMMARY Cytochrome P450 monooxygenases (CYPs) are well known for their ability to catalyze diverse oxidation reactions, playing a significant role in the biosynthesis of various natural products. In the realm of monoterpenoid indole alkaloids (MIAs), one of the largest groups of alkaloids in nature, CYPs are integral to reactions such as hydroxylation,
Zhan Mai, Kyunghee Kim, Matthew Bailey Richardson, Daniel André Ramey Deschênes, Jorge Jonathan Oswaldo Garza‐Garcia, Mohammadamin Shahsavarani, Jacob Owen Perley, Destiny Ichechi Njoku, Ghislain Deslongchamps, Vincenzo De Luca, Yang Qu   +10 more
wiley   +1 more source

Cytological changes in meristematic cells of Allium cepa L. root tip treated with extracts from callus of Catharanthus roseus (L.) G. Don

Acta Societatis Botanicorum Poloniae, 2014
The effect of an ethanolic extract from callus of Catharanthus roseus on Allium cepa root cells divisions was investigated. Two lines: white and green callus, were established on solid B5 medium with IAA 1 mg/l and kinetin 0.1 mg/l.
Agnieszka Pietrosiuk, Mirosława Furmanowa, Alicja Zobel, Mieczysław Kuraś, Agnieszka Michalak   +4 more
doaj   +1 more source

The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia

Pediatric Blood &Cancer, Volume 71, Issue 11, November 2024.
Abstract An attractive flower from the island of Madagascar has in part saved the lives of thousands of children with acute lymphoblastic leukemia (ALL). Random mutations and alterations to the genome led to the evolution of genes encoding enzymes, which would provide the periwinkle flower an arsenal of secondary metabolites to survive within the ...
Jeffrey W. Taub, Steven A. Buck, Ana C. Xavier, Holly Edwards, Larry H. Matherly, Yubin Ge   +5 more
wiley   +1 more source

Procedures to evaluate potential of plants as natural food preservatives: Phytochemical characterization, novel extraction technology, and safety evaluation—A comprehensive review

Food Science &Nutrition, Volume 12, Issue 9, Page 6142-6156, September 2024.
The use of plant extracts and EOs as preservatives in food products is a growing trend. Artemisia revealed good antimicrobial and antioxidant effects. Artemisia can be a novel natural agent for food preservation. The recent developments in extraction of Artemisia are discussed.
Negin Ahmadi, Nazanin Mosleh, Mahta Yeganeh, Nadia Ahmadi, Sara Malakouti, Saleh Shahsavari, Reza Shahraki, Somaye Katebi, Mina Agapoor, Sonia Sadeghi, Karim Bagheri   +10 more
wiley   +1 more source

Boosting Sensitivity in Liquid Chromatography–Fourier Transform Ion Cyclotron Resonance–Tandem Mass Spectrometry for Product Ion Analysis of Monoterpene Indole Alkaloids

Frontiers in Plant Science, 2015
In metabolomics, the analysis of product ions in tandem mass spectrometry (MS/MS) is noteworthy to chemically assign structural information. However, the development of relevant analytical methods are less advanced.
Ryo eNakabayashi, Hiroshi eTsugawa, Mariko eKitajima, Hiromitsu eTakayama, Kazuki eSaito, Kazuki eSaito   +5 more
doaj   +1 more source

Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus

New Phytologist, Volume 242, Issue 3, Page 1156-1171, May 2024.
Summary In Catharanthus roseus, monoterpenoid indole alkaloids (MIAs) are produced through the cooperation of four cell types, with final products accumulating in specialized cells known as idioblasts and laticifers. To explore the relationship between cellular differentiation and cell type‐specific MIA metabolism, we analyzed the expression of MIA ...
Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda‐Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah E. O'Connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai   +15 more
wiley   +1 more source

Chromium-induced alkaloid production in Catharanthus roseus (L.) G.Don in vitro cultured shoots and related gene expression patterns particularly for the novel gene GS

Acta Agriculturae Slovenica, 2019
This study aimed to determine the effects of methyl jasmonate (Mj) combined with chromium (Cr) as elicitor on production of medicinal alkaloids, its antioxidant potential, and its effects on the expression of signaling and biosynthetic enzymes.
Elham KHATAEE, Farah KARIMI, Khadijeh RAZAVI   +2 more
doaj   +1 more source