Clinical Pharmacology of Vinpocetine: Properties Revisited and Introduction of a Population Pharmacokinetic Model for Its Metabolite, Apovincaminic Acid (AVA) [PDF]
Pharmaceutics, 2023 This paper examines the use of vinpocetine in the context of clinical pharmacology. The main and active metabolite of vinpocetine is apovincaminic acid (AVA).
Zvonimir Petric +3 more
doaj +2 more sources
Unlocking vinpocetine's oncostatic potential in early-stage hepatocellular carcinoma: A new approach to oncogenic modulation by a nootropic drug. [PDF]
PLoS ONEThe development of new drugs for the inhibition of hepatocellular carcinoma (HCC) development and progression is a critical and urgent need. The median survival rate for HCC patients remains disappointingly low. Vinpocetine is a safe nootropic agent that
Osama A Mohammed +19 more
doaj +2 more sources
Vinpocetine improved neuropsychiatric and epileptic outcomes in a patient with a GABRA1 loss‐of‐function variant [PDF]
Annals of Clinical and Translational Neurology, 2023 Vinpocetine is a synthetic derivative of the alkaloid vincamine and has been used as a dietary supplement for decades. Following a positive report of the use of vinpocetine in a patient with a loss‐of‐function GABRB3 variant, we here describe another ...
Cathrine E. Gjerulfsen +9 more
doaj +2 more sources
Effect of vinpocetine on embryonic heart rate in vitro [PDF]
Current Research in Toxicology, 2023 Vinpocetine is a readily available nutritional supplement claimed to improve memory and weight loss. However, it blocks the Ikr current essential for cardiac action potential repolarisation and Ikr inhibition can cause “torsade de pointes” arrhythmias ...
Helen Elizabeth Ritchie +3 more
doaj +2 more sources
Synthesis and Activity Evaluation of Vinpocetine-Derived Indole Alkaloids [PDF]
Molecules, 2023 This study focuses on the synthesis of novel vinpocetine derivatives (2–25) and their biological evaluation. The chemical structures of the synthesized compounds were fully characterized using techniques such as 1H NMR, 13C NMR, and HRMS.
Zhang-Chao Dong +7 more
doaj +2 more sources
Potential Use of Common Administration of Emulsion for Parenteral Nutrition and Vinpocetine: Compatibility Study and Prospect [PDF]
MetabolitesVinpocetine (VP) is distributed after oral and intravenous administration, and its uptake in the thalamus, basal ganglia, and visual cortex. Due to poor bioavailability (~7%) and marked first-pass effect (~75%), including a short half-life (2–3 h), oral ...
Szymon Tomczak +4 more
doaj +2 more sources
Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development [PDF]
Brain SciencesBackground/Objectives Studies in rodents indicate that disruptions in both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling pathways are involved in the development of hyperactive behavior.
Ulisses C. Araujo +9 more
doaj +2 more sources
Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways [PDF]
Scientific ReportsThis study aimed to investigate the potential anti-fibrotic activity of vinpocetine in an experimental model of pulmonary fibrosis by bleomycin and in the MRC-5 cell line.
Zeena A. Hussein +5 more
doaj +2 more sources
Anti-inflammatory effects of vinpocetine in LPS-stimulated microglia via activation of AMPK [PDF]
Anais da Academia Brasileira de Ciências, 2020 Microglia are the resident immune cells in the central nervous system (CNS), which play important roles in the repair of neuroinflammatory injury.
QIN ZHOU +6 more
doaj +1 more source
Study of the effects of vinpocetine on indicators of acidalkaline state followıng the ischemic brain damage [PDF]
Infarma: Pharmaceutical Sciences, 2023 Vinpocetine is a multipurpose medicine with several pharmacological targets. It is known for its neuroprotective properties. Its mechanism of action in brain pathology is due to a selective inhibitor of phosphodiesterase type 1, inhibition of voltage ...
Larisa M. Makarova +6 more
doaj +1 more source