Results 41 to 50 of about 1,667 (200)

Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle

Biomedicines, 2022
Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using
Wei-Chia Lee, Hong-Ren Yu, You-Lin Tain, Kay L.H. Wu, Yao-Chi Chuang, Julie Y.H. Chan   +5 more
doaj   +1 more source

Renoprotective effect of vinpocetine and cilostazol on glycerol induced renal injury in male rats

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
 Acute kidney injury (AKI) is characterized by a sudden loss of kidney function that is established by increased serum creatinine levels and decreased urinary output. AKI is one of a group of functional kidney conditions known as acute kidney disease
Duaa Ahmed, Ghaith Ali Jasim
doaj   +1 more source

Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease. [PDF]

BJU Int
Objectives To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.
Harding SL, Ilg MM, Bustin SA, Ralph DJ, Cellek S.   +4 more
europepmc   +2 more sources

Deep Supramolecular Language Processing for Co‐Crystal Prediction

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
DeepCocrystal is a deep learning model that predicts co‐crystal formation by learning supramolecular interactions from molecular string representations. It achieves high accuracy, estimates uncertainty, and offers interpretable insights into its predictions. Validated prospectively, DeepCocrystal discovered novel diflunisal co‐crystals and is available
Rebecca Birolo, Rıza Özçelik, Andrea Aramini, Roberto Gobetto, Michele R. Chierotti, Francesca Grisoni   +5 more
wiley   +2 more sources

Vinpocetine regulates HG-induced cell signaling.

, 2014
A: Representative immunoblots of ERK1/2, p38, JNK phosphorylation and their own total protein levels. B: Vinpocetine prevents HG-stimulated PI3K/Akt activation. C: Vinpocetine inhibits HG-induced IκBα activation.
Baoxin Liu (167406), Li Wen (169316), Hailing Li (126961), Xiankai Li (434460), Yuyan Lu (494575), Wenhui Peng (126960), Jianhui Zhuang (126958), Ke Wang (82395), Yawei Xu (126970), Weiming Li (126966)   +9 more
core   +1 more source

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

Mediators of Inflammation, 2019
Clinically active drugs for the treatment of acute pain have their prescription limited due to the significant side effects they induce. An increase in reactive oxygen species (ROS) has been linked to several conditions, including inflammation and pain ...
Yuri Lourenco-Gonzalez, Victor Fattori, Talita P. Domiciano, Ana C. Rossaneis, Sergio M. Borghi, Tiago H. Zaninelli, Catia C. F. Bernardy, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri   +11 more
doaj   +1 more source

Vinpocetine as a potent antiinflammatory agent [PDF]

Proceedings of the National Academy of Sciences, 2010
Chronic inflammatory processes are related to conditions as distinct as atherosclerosis, amyotrophic lateral sclerosis, asthma, systemic lupus, Alzheimer's disease, and Parkinson's disease. The continuous use of antiinflammatory agents is required to treat these conditions.
openaire   +2 more sources

Inhibition of PDE1-B by Vinpocetine Regulates Microglial Exosomes and Polarization Through Enhancing Autophagic Flux for Neuroprotection Against Ischemic Stroke

Frontiers in Cell and Developmental Biology, 2021
Exosomes contribute to cell–cell communications. Emerging evidence has shown that microglial exosomes may play crucial role in regulation of neuronal functions under ischemic conditions.
Jiankun Zang, Jiankun Zang, Yousheng Wu, Yousheng Wu, Xuanlin Su, Xuanlin Su, Tianyuan Zhang, Tianyuan Zhang, Xionglin Tang, Xionglin Tang, Xionglin Tang, Dan Ma, Yufeng Li, Yufeng Li, Yanfang Liu, Yanfang Liu, Ze’an Weng, Ze’an Weng, Xuanzhuo Liu, Xuanzhuo Liu, Chi Kwan Tsang, Anding Xu, Anding Xu, Dan Lu, Dan Lu   +24 more
doaj   +1 more source

Development and Validation of UV-Spectrophotometric Method for Estimation of Vinpocetine in Marketed Formulation and Nanoformulation

, 2023
A quick, accurate, and cost-effective UV spectroscopy method was developed to estimate the Vinpocetine concentration in bulk, tablet dosage formulations and niosomes formulations, using a solvent ratio of (6:4) methanol: water.
Chimagave, Supriya, Patil, Swapnil, Kurangi, Bhaskar, Soudagar, Moazzim, Kumar HB, Chethan   +4 more
core   +1 more source

Pre-treatment with vinpocetine protects against retinal ischemia

, 2017
Vinpocetine has been shown to have beneficial effects for tissues of the central nervous system subjected to ischemia and other related metabolic insults.
Acosta Etchebarne, Monica, Nivison-Smith, L, Khoo, P, Kalloniatis, M   +3 more
core   +1 more source