Results 51 to 60 of about 1,667 (200)

Neuroprotective Effect of Vinpocetine against Lead Acetate-Instigated Neurotoxicity in Rats by Evaluation Tumor Necrosis Factor-Alpha, Interleukin-1Beta and Interleukin-10

Iraqi Journal of Pharmaceutical Sciences, 2022
Lead toxicity elicits neurological damage which is a well-known disorder that has been considered to be a major cause for multiple condition such as behavioral defect; mental retardation; and nerve insufficient activity.
Manal Abdulkhaliq Ibrahim, Wameed Hashim Abbas, Muhsin Sagheer Ghalib, Nada N. Najia Al-Shawi   +3 more
doaj   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Vinpocetine inhibited the osteoblastic differentiation of VSMCs via TSPO.

, 2016
As it was shown, VSMCs were treated with or without vinpocetine under different conditions. After the culture, cells were harvested for the analysis of the mRNA expression of TSPO.
Qiu-Hua Liang (326253), Min Song (57124), Na Wang (193263), Yu-Zhong Wang (1401262), Yun-Yun Ma (3098151), Xiu-Juan Chen (3098148), Bo Zhang (6559), Peng-Fei Yi (3098145), Lin Sun (105539)   +8 more
core   +1 more source

Repositioning vinpocetine: Behavioral and neurochemical modulation in a fibromyalgia-like model in mice [PDF]

Records of Pharmaceutical & Biomedical Sciences
Purpose: Fibromyalgia (FM) is a debilitating condition that dramatically impairs quality of life. Neuroinflammation is a plausible initiator of a cascade of events leading to aberrant neuronal excitability. Since the available treatment options of FM are
Wafaa Hewedy, Doaa Ghareeb, Aliaa Masoud
doaj   +1 more source

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

Vinpocetine modulates metabolic activity and function during retinal ischemia

, 2015
Vinpocetine protects against a range of degenerative conditions and insults of the central nervous system via multiple modes of action. Little is known, however, of its effects on metabolism.
Acosta Etchebarne, Monica, Truong, M, Nivison-Smith, L, Guo, Xiaopeng, Kalloniatis, M, O'Brien, BJ   +5 more
core   +1 more source

Flow Cytometry Role in Unlocking New Frontiers for Nanomedicine Applications of Plant‐Derived Vesicles

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound vesicles released by any cell type under both physiological and pathological conditions. They carry a wide array of bioactive molecules, including microRNAs (miRNAs), lipids, proteins and other small biomolecules, and therefore play a key role in intercellular communication by ...
Tamer Esmail, Sabino Porro, Francesca D'Ascanio, Domenico De Bellis, Arianna Aquilini‐Mummolo, Giulia Colasante, Pasquale Simeone, Ayesha Younas, Marwa Balaha, Mariagiulia Filoso, Luana D'Onofrio, Melania Dovizio, Eleonora Aruffo, Piero Di Carlo, Lorenzo Secondi, Federica Flamminii, Tiziana Pietrangelo, Chiara Porro, Patrizia Ballerini, Angelo Cichelli, Paola Lanuti   +20 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Enantiospecific crystallisation behaviour of malic acid in mechanochemical reactions with vinpocetine [PDF]

: We report an intriguing example of enantioselectivity in the formation of new multicomponent crystalline solid containing vinpocetine and malic acid.
Birolo, Rebecca, D'Abbrunzo, Ilenia, Bučar, Dejan-Krešimir, Hasa, Dritan, Chierotti, Michele R., Voinovich, Dario, Perissutti, Beatrice   +6 more
core   +1 more source