Results 61 to 70 of about 1,667 (200)

Efficiency of long-term vinpocetine administration in the treatment of dizziness and associated statodynamic disorders in patients with chronic cerebrovascular insufficiency (EDELWEISS study)

Неврология, нейропсихиатрия, психосоматика, 2019
Complaints of dizziness are common in patients diagnosed with chronic cerebrovascular insufficiency (CCVI). Effective therapy of these patients is one of the most urgent problems of outpatient neurological practice.Objective: to evaluate the efficiency ...
I. N. Samartsev, S. A. Zhivolupov, Yu. S. Butakova, M. V. Morozova, I. N. Barsukov   +4 more
doaj   +1 more source

Modeling the Formation of Liposomes with Vinpocetine from Soy Lecithin Phospholipids by Molecular Dynamics

Разработка и регистрация лекарственных средств, 2021
Introduction. Liposomal preparations have the following advantages: they protect body cells from the toxic effects of drugs; prolong the action of the drug introduced into the body; protect medicinal substances from degradation; promote the manifestation
Yu. A. Polkovnikova
doaj   +1 more source

Early‐Onset Movement Disorder Syndrome Caused by Biallelic Variants in PDE1B Encoding Phosphodiesterase 1B

Movement Disorders, Volume 40, Issue 9, Page 1874-1882, September 2025.
Abstract Background Breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in basal ganglia cells through hydrolysis of diesteric bonds, primarily by PDE10A and PDE1B, is essential for normal human movement. While biallelic loss‐of‐function variants in PDE10A are known to cause hyperkinetic movement disorders, the ...
Tomer Poleg, Noam Hadar, Eyal Kristal, Nicola Y. Roberts, Vadim Dolgin, Ilana Aminov, Amit Safran, Nadav Agam, Matan Jean, Ofek Freund, Eamonn G. Sheridan, James A. Poulter, Michelle L. Thompson, Yusra Algoos, Salma Al‐Qahtani, Lama AlAbdi, Sateesh Maddirevula, Verity Hartill, Henry Houlden, Reza Maroofian, Amit Nahum, Ohad S. Birk   +21 more
wiley   +1 more source

IS THERE TREATMENT EFFECT OF VINPOCETINE ON AUTONOMIC DYSFUNCTION IN RATS WITH ALZHEIMER

, 2017
Alzheimer's disease (AD) shows less autonomic dysfunction. There was lack of response or prolongation of its latency in skin sympathetic response. Vinpocetine is a classic inhibitor of PDE1 activity.
Hale Acer, Nazan Dolu, Seda Gündüz, Selda Tasa, Azizuddin Khan, Ali Yucel Kara   +5 more
core   +2 more sources

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

Frontiers in Neuroscience, 2014
Some anti-inflammatory medications reduce alcohol consumption in rodent models. Inhibition of phosphodiesterases (PDE) increases cAMP and reduces inflammatory signaling.
Yuri A. Blednov, Jillian M. Benavidez, Mendy eBlack, R. Adron eHarris   +3 more
doaj   +1 more source

Improving Biopharmaceutical Properties of Vinpocetine Through Cocrystallization [PDF]

, 2016
Vinpocetine is a poorly water soluble weakly basic drug (pKa 1⁄4 7.1) used for the treatment of several cerebrovascular and cognitive disorders. Because existing formulations exhibit poor bioavailability and scarce absorption, a dosage form with improved
GRABNAR, IZTOK, LASSIANI, LUCIA, Zaworotko, Michael J., GOLOB, SAMUEL, Perry, Miranda, Chierotti, Michele R., Lusi, Matteo, VOINOVICH, DARIO   +7 more
core   +1 more source

The ideal duo for salt formation: vinpocetine and tosylic acid [PDF]

Two novel soluble salts of vinpocetine were prepared through simple and highly sustainable mechanochemical methods. Specifically, water-assisted grinding led to the formation of a crystalline, anhydrous, equimolar salt with p-toluenesulfonic acid ...
D'Abbrunzo, Ilenia, Bassato, Ferdinando, Procida, Giuseppe, Gigli, Lara, Beltrame, Francesca, Cepek, Cinzia, Voinovich, Dario, Demitri, Nicola, Perissutti, Beatrice   +8 more
core   +1 more source

Vinpocetine Inhibits Oligodendroglial Precursor Cell Differentiation [PDF]

Cellular Physiology and Biochemistry, 2012
In multiple sclerosis during periods of remission a limited degree of myelin repair can be observed mediated by oligodendroglial precursor cells. Phosphodiesterase inhibitors act as anti-inflammatory agents and might hold promise for future multiple sclerosis treatment.To investigate whether phosphodiesterase inhibitors could also influence myelin ...
Klintsy Julieta, Torres, Peter, Göttle, David, Kremer, Jose Flores, Rivera, Lucinda, Aguirre-Cruz, Teresa, Corona, Hans-Peter, Hartung, Patrick, Küry   +7 more
openaire   +2 more sources

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

Movement Disorders, Volume 40, Issue 7, Page 1307-1317, July 2025.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles, Dilan Athauda, Thomas R. Barber, Roger A. Barker, David T. Dexter, Susan Duty, Romy Ellis‐Doyle, Sonia Gandhi, Joel Handley, Edwin Jabbari, Keith Martin, Kevin McFarthing, Georgia Mills, Heather Mortiboys, Stephen Mullin, Rebecca Petty, Esther Sammler, Paula Scurfield, Simon R.W. Stott, George K. Tofaris, Li Wei, Caroline H. Williams‐Gray, Alan Wong, Marie‐Louise Zeissler, Richard K. Wyse, Camille B. Carroll, Thomas Foltynie, Oliver Bandmann, Anthony H.V. Schapira, on behalf of the EJS ACT‐PD Consortium, Thomas Foltynie, Camille B Carroll, Roger Barker, James Carpenter, Yoav Ben‐Shlomo, Mark Edwards, Alan Whone, Carl Counsell, Caroline S Clarke, Matthew Burnell, Kate Hockey, Anna Jewell, Priti Gros, Tom Barber, Anette Schrag, Rimona S Weil, Caroline H Williams‐Gray, Michele T Hu, Lynn Rochester, Paola Piccini, Henrik Zetterberg, Alastair Noyce, Michael Lawton, Ashwani Jha, Brook Huxford, Shlomi Haar Millo, K. Ray Chaudhuri, Carroll Siu, Michèle Bartlett, Kuhan Pushparatnam, Daniel van Wamelen, Anthony HV Schapira, Oliver Bandmann, Simon Stott, George Tofaris, Esther Sammler, Heather Mortiboys, Li Wei, Alan Wong, Susan Duty, David Dexter, Edwin Jabbari, Stephen Mullin, Huw Morris, David Breen, Christian Lambert, Prasad Korlipara, Monty Silverdale, Kailash Bhatia, Alison Yarnall, Raj Khengar, Helen Collins, Fleur Hudson, Rebecca Croucher, Sandra Bartolomeu‐Pires, Veena Agarwal, Jennifer Allison, Jodie Forbes, Alex Edwards, Sheila Wonnacott, Dilan Athauda, Joy Duffen, Sonia Gandhi, Emily Henderson, Jen Black, Karen Matthews, Vince Greaves, Eric Deeson, Laurel Miller, Joel Handley, Helen Matthews, Kevin McFarthing, Amit Batla, Nikul Bakshi, Miriam Parry, Natasha Ratcliffe, Cheney Drew, Naveena Kapur, Anaya Navangul, Shafaq Ali, Katherine Fletcher, Claire Bale, Cristina Gonzalez‐Robles, Marie‐Louise Zeissler, Georgia Mills, Romy Ellis‐Doyle, Sally Collins, Rebecca Petty   +117 more
wiley   +1 more source

The nootropic drug vinpocetine modulates different types of potassium currents in molluscan neurons

, 2001
Three types of high-threshold K+ currents were recorded in isolated neurons of the snail Helix pomatia using a two-microelectrode voltage clamp technique: transient K+ current (IA), delayed rectifier (IKD) and Ca2+-dependent K+ current (IK(Ca ...
Bukanova, J.V., Solntseva, E.I., Julia V. Bukanova, Vladimir G. Skrebitsky, Skrebitsky, V.G., Elena I. Solntseva   +5 more
core   +1 more source