Results 71 to 80 of about 1,667 (200)

Vinpocetine reduces carrageenan-induced inflammatory hyperalgesia in mice by inhibiting oxidative stress, cytokine production and NF-κB activation in the paw and spinal cord.

PLoS ONE, 2015
Vinpocetine is a safe nootropic agent used for neurological and cerebrovascular diseases. The anti-inflammatory activity of vinpocetine has been shown in cell based assays and animal models, leading to suggestions as to its utility in analgesia. However,
Kenji W Ruiz-Miyazawa, Ana C Zarpelon, Felipe A Pinho-Ribeiro, Gabriela F Pavão-de-Souza, Rubia Casagrande, Waldiceu A Verri   +5 more
doaj   +1 more source

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, Volume 310, Issue 6, June 2025.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

The Potential Hepatoprotective Effect of Vinpocetine against Lead-Induced Inflammatory and Apoptotic Cytokines in Rats

Iraqi Journal of Pharmaceutical Sciences
Environmental pollution with heavy metals like lead has become a matter of concern, the accumulation and multi-systemic toxicity of lead affect most body organs and its toxicity is related with many pathological changes, especially on liver.
Manal Abdulkhaliq Ibrahim, SARAH OMRAN, Noora S. Ghalib, Nada N. Al-Shawi   +3 more
doaj   +1 more source

Estratégias de neuroprotecção. Efeitos da vimpocetina em modelos in vitro de stresse oxidativo.

Acta Médica Portuguesa, 2003
Reactive oxygen species (ROS) play an important role in neuronal damage and death that occurs in several neurodegenerative disorders, namely in Alzheimer's disease (AD).
Cláudia Pereira, Paula Agostinho, Paula I Moreira, Ana I Duarte, Maria S Santos, Catarina R Oliveira   +5 more
doaj   +1 more source

Dual Roles of Autophagy in Radiation‐Induced Brain Injury: Mechanistic Insights and Therapeutic Implications

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Under varying conditions, autophagy plays a dualistic role in radiation‐induced brain injury (RIBI), interacting intricately with apoptosis, ferroptosis, neuroinflammation, oxidative stress, blood–brain barrier (BBB) disruption, mitophagy, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.
Jiayu Tian, Yanna Mao, Dandan Liu, Tao Li, Lihuan Shi, Yafeng Wang, Changlian Zhu   +6 more
wiley   +1 more source

Dementia in a resource‐constrained sub‐Saharan African setting: A comprehensive retrospective analysis of prevalence, risk factors, and management at the only neuropsychiatric facility in Northeastern Nigeria

Alzheimer's &Dementia, Volume 21, Issue 3, March 2025.
Abstract INTRODUCTION Dementia prevalence is increasing in sub‐Saharan Africa, potentially due to population growth and aging. Resource‐constrained settings such as Northeastern Nigeria face challenges in dementia management. METHODS We assessed dementia burden and management at the Federal Neuropsychiatric Hospital Maiduguri, the only neuropsychiatric
Ibrahim Abdu Wakawa, Umar Baba Musami, Suleiman Hamidu Kwairanga, Placidus Nwankuba Ogualili, Mohammed Yusuf Mahmood, Muhammad Abba Fugu, Mohammed Mala Gimba, Muktar Mohammed Allamin, Zaharadeen Umar Abbas, Muhammad Kawu Sunkani, Zainab Bukar Yaganami, Fatima Mustapha Kadau, Nasir Muhammad Sani, Peter Danmallam, Luka Nanjul, Larema Babazau, Zaid Muhammad, Baba Waru Goni, Babagana Kundi Machina, Celeste M. Karch, Chinedu Udeh‐Momoh, Thomas K. Karikari, Chiadi U. Onyike, Mahmoud Bukar Maina   +23 more
wiley   +1 more source

A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines

Advanced NanoBiomed Research, Volume 5, Issue 3, March 2025.
Nanomaterial‐integrated microneedles revolutionize transdermal delivery, enabling targeted and controlled administration of therapeutics and vaccines. This review explores advancements in design, manufacturing, and applications, emphasizing enhanced drug stability, bioavailability, and patient adherence. Key preclinical and clinical findings as well as
Bwalya Angel Witika, Aaron Hutton, Pedzisai A. Makoni, Ryan F. Donnelly   +3 more
wiley   +1 more source

UV SPECTROPHOTOMETRY APPLICATION FOR QUANTITATIVE DETERMINATION OF VINPOCETINE IN DRUG FORMULATIONS

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
Introduction. In this paper simple, rapid and sensitive assay methods for quantitative determination of vinpocetine in two new drug formulations (suppositories and nasal cream) are proposed.
J. V. Monaykina, N. O. Nagorna, V. V. Nagorniy, S. O. Vasjuk   +3 more
doaj   +1 more source

Concurrent Intravenous Drug Administration to the Critically Ill: Compatibility of Ginkgo Biloba Extract With Frequently Used Drugs in the Neurological Intensive Care Unit

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Objective Ginkgo biloba extract (EGB), a traditional Chinese medicine extracted from the Ginkgophyta, was used to regulate various neurological disorders (NDs). Limited compatibility data exist on EGB after marketing with other drugs administered simultaneously through the Y‐site.
Haiwen Ding, Tong Tong, Jie Li, Zhaolin Chen, Liqin Tang, Sheng Liu, Peifang Li, Ali Imran   +7 more
wiley   +1 more source

Nanoparticles Navigating the Intranasal Route: Innovative Approaches in Neurodegenerative Diseases

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
Intranasal drug delivery is emerging as a transformative strategy for treating neurodegenerative diseases, offering a noninvasive route that bypasses the limitations of the blood–brain barrier. This review provides a comprehensive analysis of the current landscape and challenges of intranasal drug delivery for neurodegenerative conditions with an ...
Fabiola V. Borbolla-Jiménez, Stephany Celeste Gutiérrez-Ruiz, Hector Hernández-Parra, Sheila I. Peña-Corona, Aura A. Tamez, Ricardo D. Rivas-Amores, Jonathan J. Magaña, Gerardo Leyva-Gomez, Nasrullah Jan   +8 more
wiley   +1 more source