Revisiting the Reduction of Vinpocetine [PDF]
ChemistrySelect, Volume 10, Issue 7, February 19, 2025.This study explores the reduction of C16‐C17 double bond of vinpocetine, yielding two epimers previously stereochemically misassigned. The correct stereochemical assignment is established by comprehensive NMR characterization, computational studies and X‐ray crystallography. Different reduction conditions and the corresponding epimer ratio are reported.
Simone Borsoi +8 more
wiley +3 more sources
Thermogravimetric study of vinpocetine suppository
Zaporožskij Medicinskij Žurnal, 2014 Introduction. Development of technology is the one of the main stage in creation of new medications. Technological process of suppository manufacturing includes sufficiently long thermoprocessing during suppository base making, addition of the active ...
N. А. Nаgоrnaya +2 more
doaj +5 more sources
Vinpocetine Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. [PDF]
PLoS ONE, 2016 Vascular calcification is an active process of osteoblastic differentiation of vascular smooth muscle cells; however, its definite mechanism remains unknown.
Yun-Yun Ma +8 more
doaj +2 more sources
Vinpocetine attenuates neointimal hyperplasia in diabetic rat carotid arteries after balloon injury. [PDF]
PLoS ONE, 2014 BACKGROUND: Diabetes exacerbates abnormal vascular smooth muscle cell (VSMC) accumulation in response to arterial wall injury. Vinpocetine has been shown to improve vascular remolding; however, little is known about the direct effects of vinpocetine on ...
Ke Wang +9 more
doaj +2 more sources
SIMULATION OF VINPOCETINE RELEASE PROCESS FROM MICROCAPSULES WITH HYDROPHOBIC SHELL
Фармация и фармакология (Пятигорск), 2017 Nowadays microcapsules are widely spread in different industries. Microcapsules with vitamins, etheric and fatty oils are included into different cosmetics (creams, gels, serums).
Yu. A. Polkovnikova +3 more
doaj +3 more sources
Inhibitory effects of vinpocetine on the progression of atherosclerosis are mediated by Akt/NF-κB dependent mechanisms in apoE-/- mice. [PDF]
PLoS ONE, 2013 BackgroundRecent studies have found additional roles for vinpocetine, a potent phosphodiesterase type I inhibitor, in anti-proliferation and anti-inflammation of vascular smooth muscle cells and cancer cells via different mechanisms.
Jianhui Zhuang +7 more
doaj +2 more sources
Vinpocetine for Cognitive Impairment and Dementia
Cochrane Database of Systematic Reviews, 2003 Background: Vinpocetine is a synthetic ethyl ester of apovincamine, a vinca alkaloid obtained from the leaves of the Lesser Periwinkle (Vinca minor) and discovered in the late 1960s. Although used in human treatment for over twenty years, it has not been
Whitehouse, Peter J.
core +4 more sources
THE DEVELOPMENT OF VINPOCETINE AND AMBER ACID IN JOINT PRESENCE ANALYSIS METHODS
Фармация и фармакология (Пятигорск), 2015 The article presents the data about the possibility of joint use of vinpocetine with amber acid, solubility of vinpocetine improvement and the methods of their analysis in joint use.
S. G. Tiraspolskaya, Z. I. Shavlukhova
doaj +3 more sources
Study of the deposition process of vinpocetine on the surface of porous silicon
Results in Physics, 2016 Currently the most prospective way in pharmacotherapy is the obtaining of nanoparticles involving pharmaceutical substances. Application of porous inorganic materials on the basis of silicon is among the main features in solving of this problem.
A.S. Lenshin +2 more
doaj +2 more sources
Studies on Pharmacokinetic Drug Interaction Potential of Vinpocetine [PDF]
Medicines, 2015 Background: Vinpocetine, a semi-synthetic derivative of vincamine, is a popular dietary supplement used for the treatment of several central nervous system related disorders.
Bharathi Avula +6 more
core +3 more sources