Results 81 to 90 of about 2,799,905 (389)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

No buffer effect of perceived social support for people exposed to violence during the COVID-19 pandemic: a cross-sectional community study

open access: yesEuropean Journal of Psychotraumatology, 2021
Background: The COVID-19 pandemic has represented a burden to communities worldwide. Research indicates that this burden is not equally distributed in the community, and vulnerable groups, such as violence-exposed individuals may pay a particularly high ...
Marianne Skogbrott Birkeland   +2 more
doaj   +1 more source

Intimate partner violence.

open access: yesPediatrics in review, 2010
1. Megan H. Bair-Merritt, MD, MSCE* 1. *Assistant Professor of Pediatrics, Associate Director, Primary Care Fellowship Program, Johns Hopkins School of Medicine, Baltimore, Md. After completing this article, readers should be able to: 1. Describe
M. Bair-Merritt
semanticscholar   +1 more source

The violence of disablism [PDF]

open access: yesSociology of Health & Illness, 2011
AbstractThis article addresses the multi‐faceted nature of violence in the lives of disabled people, with a specific focus on the accounts of disabled children and their families. Traditionally, when violence and disability have been considered together, this has emphasised the disabled subject whom inevitably exhibits violent challenging behaviour ...
Katherine Runswick-Cole, Dan Goodley
openaire   +3 more sources

Intimate Partner Violence and Sexual Violence in the Kodiak Island Borough: Key Results from the 2012 Alaska Victimization Survey [PDF]

open access: yes, 2012
This document is a two-page summary of the key results from the 2012 Alaska Victimization Survey for the Kodiak Island Borough, which was conducted from March to May 2012, with results released on October 4, 2012 in Kodiak.
Rosay, André B.
core  

Slow violence and toxic geographies: ‘Out of sight’ to whom?

open access: yesEnvironment and Planning C Politics and Space, 2019
Toxic pollution is a form of violence. This article explores the gradual brutalities that communities surrounded by petrochemical infrastructure endure over time.
T. Davies
semanticscholar   +1 more source

Violence and Complexity [PDF]

open access: yesThe Open Psychology Journal, 2015
Like all the phenomena that the human mind is knowledgeable about, the phenomenon of violence should be regarded as a complex macrosystem, where systems of networks and agents are linked and interact at different interconnected levels. This means that complexity refers to the phenomenon per se, to the various cognitive and emotional processes through ...
openaire   +6 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Communities Engaged in Resisting Violence [PDF]

open access: yes, 2007
"Communities Engaged in Resisting Violence" documents a new movement in Chicago that seeks to end violence against women through community engagement and accountability, rather than solely social services and criminal justice.
Ann Russo, Melissa Spatz
core  

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