Results 81 to 90 of about 2,799,905 (389)
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao+7 more
wiley +1 more source
Background: The COVID-19 pandemic has represented a burden to communities worldwide. Research indicates that this burden is not equally distributed in the community, and vulnerable groups, such as violence-exposed individuals may pay a particularly high ...
Marianne Skogbrott Birkeland+2 more
doaj +1 more source
1. Megan H. Bair-Merritt, MD, MSCE* 1. *Assistant Professor of Pediatrics, Associate Director, Primary Care Fellowship Program, Johns Hopkins School of Medicine, Baltimore, Md. After completing this article, readers should be able to: 1. Describe
M. Bair-Merritt
semanticscholar +1 more source
The violence of disablism [PDF]
AbstractThis article addresses the multi‐faceted nature of violence in the lives of disabled people, with a specific focus on the accounts of disabled children and their families. Traditionally, when violence and disability have been considered together, this has emphasised the disabled subject whom inevitably exhibits violent challenging behaviour ...
Katherine Runswick-Cole, Dan Goodley
openaire +3 more sources
Intimate Partner Violence and Sexual Violence in the Kodiak Island Borough: Key Results from the 2012 Alaska Victimization Survey [PDF]
This document is a two-page summary of the key results from the 2012 Alaska Victimization Survey for the Kodiak Island Borough, which was conducted from March to May 2012, with results released on October 4, 2012 in Kodiak.
Rosay, André B.
core
Slow violence and toxic geographies: ‘Out of sight’ to whom?
Toxic pollution is a form of violence. This article explores the gradual brutalities that communities surrounded by petrochemical infrastructure endure over time.
T. Davies
semanticscholar +1 more source
Like all the phenomena that the human mind is knowledgeable about, the phenomenon of violence should be regarded as a complex macrosystem, where systems of networks and agents are linked and interact at different interconnected levels. This means that complexity refers to the phenomenon per se, to the various cognitive and emotional processes through ...
openaire +6 more sources
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi+5 more
wiley +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää+2 more
wiley +1 more source
Communities Engaged in Resisting Violence [PDF]
"Communities Engaged in Resisting Violence" documents a new movement in Chicago that seeks to end violence against women through community engagement and accountability, rather than solely social services and criminal justice.
Ann Russo, Melissa Spatz
core