Results 1 to 10 of about 63,532 (247)

In Vitro Immunological Cross-Reactivity of Thai Polyvalent and Monovalent Antivenoms with Asian Viper Venoms [PDF]

Toxins, 2020
The intravenous administration of polyclonal antibodies known as antivenom is the only effective treatment for snakebite envenomed victims, but because of inter-specific variation in the toxic components of snake venoms, these therapies have variable ...
Janeyuth Chaisakul, Muhamad Rusdi Ahmad Rusmili, Jaffer Alsolaiss, Laura-Oana Albulescu, Robert A. Harrison, Iekhsan Othman, Nicholas R. Casewell   +6 more
doaj   +5 more sources

Venomics of the milos viper (Macrovipera schweizeri) unveils patterns of venom composition and exochemistry across blunt-nosed viper venoms [PDF]

Frontiers in Molecular Biosciences, 2023
Introduction: Snakebite is a neglected tropical disease and a globally important driver of death and morbidity. Vipers of the genus Macrovipera (Viperidae: Viperinae) are among the snakes of higher medical importance in the Old World. Despite the medical
Lennart Schulte, Lennart Schulte, Lennart Schulte, Maik Damm, Ignazio Avella, Ignazio Avella, Ignazio Avella, Lilien Uhrig, Pelin Erkoc, Pelin Erkoc, Susanne Schiffmann, Susanne Schiffmann, Robert Fürst, Robert Fürst, Thomas Timm, Günter Lochnit, Andreas Vilcinskas, Andreas Vilcinskas, Andreas Vilcinskas, Tim Lüddecke, Tim Lüddecke   +20 more
doaj   +5 more sources

A simple mortality risk prediction score for viper envenoming in India (VENOMS): A model development and validation study.

PLoS Neglected Tropical Diseases, 2022
BackgroundSnakebite is a neglected problem with a high mortality in India. There are no simple clinical prognostic tools which can predict mortality in viper envenomings.
Maya Gopalakrishnan, Suman Saurabh, Pramod Sagar, Chanaveerappa Bammigatti, Tarun Kumar Dutta   +4 more
doaj   +3 more sources

Snake Venom Metalloproteinases from Puff Adder and Saw-Scaled Viper Venoms Cause Cytotoxic Effects in Human Keratinocytes [PDF]

Toxins
Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The puff adder (Bitis arietans) and saw-scaled viper (Echis romani) have cytotoxic venoms that cause permanent injury via dermonecrosis around ...
Keirah E. Bartlett, Adam Westhorpe, Mark C. Wilkinson, Nicholas R. Casewell   +3 more
doaj   +4 more sources

Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms. [PDF]

Toxins (Basel), 2016
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms. In order to close this knowledge gap, venom proteomics and toxin activity of species of Bothriechis, and Bothrops (including Bothriopsis) were ...
Debono J, Cochran C, Kuruppu S, Nouwens A, Rajapakse NW, Kawasaki M, Wood K, Dobson J, Baumann K, Jouiaei M, Jackson TN, Koludarov I, Low D, Ali SA, Smith AI, Barnes A, Fry BG.   +16 more
europepmc   +7 more sources

Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms. [PDF]

Toxins (Basel), 2022
Snakebite envenoming is a life threatening neglected tropical disease that represents a considerable public health concern in the tropics. Viperid snakes of the genus Bothrops are among those of greatest medical importance in Latin America, and they ...
Alsolaiss J, Alomran N, Hawkins L, Casewell NR.   +3 more
europepmc   +2 more sources

Clinical and Evolutionary Implications of Dynamic Coagulotoxicity Divergences in Bothrops (Lancehead Pit Viper) Venoms. [PDF]

Toxins (Basel), 2022
Despite coagulotoxicity being a primary weapon for prey capture by Bothrops species (lancehead pit vipers) and coagulopathy being a major lethal clinical effect, a genus-wide comparison has not been undertaken.
Bourke LA, Zdenek CN, Tanaka-Azevedo AM, Silveira GPM, Sant'Anna SS, Grego KF, Rodrigues CFB, Fry BG.   +7 more
europepmc   +2 more sources

Pharmacological Characterisation of Pseudocerastes and Eristicophis Viper Venoms Reveal Anticancer (Melanoma) Properties and a Potentially Novel Mode of Fibrinogenolysis. [PDF]

Int J Mol Sci, 2021
Venoms are a rich source of potential lead compounds for drug discovery, and descriptive studies of venom form the first phase of the biodiscovery process.
Op den Brouw B, Ghezellou P, Casewell NR, Ali SA, Fathinia B, Fry BG, Bos MHA, Ikonomopoulou MP.   +7 more
europepmc   +2 more sources

Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture. [PDF]

Toxins (Basel), 2021
Snakes of the genera Pseudocerastes and Eristicophis (Viperidae: Viperinae) are known as the desert vipers due to their association with the arid environments of the Middle East.
Op den Brouw B, Coimbra FCP, Bourke LA, Huynh TM, Vlecken DHW, Ghezellou P, Visser JC, Dobson JS, Fernandez-Rojo MA, Ikonomopoulou MP, Casewell NR, Ali SA, Fathinia B, Hodgson WC, Fry BG.   +14 more
europepmc   +2 more sources

A Genus-Wide Bioactivity Analysis of Daboia (Viperinae: Viperidae) Viper Venoms Reveals Widespread Variation in Haemotoxic Properties. [PDF]

Int J Mol Sci, 2021
The snake genus Daboia (Viperidae: Viperinae; Oppel, 1811) contains five species: D. deserti, D. mauritanica, and D. palaestinae, found in Afro-Arabia, and the Russell’s vipers D. russelii and D. siamensis, found in Asia. Russell’s vipers are responsible
Op den Brouw B, Coimbra FCP, Casewell NR, Ali SA, Vonk FJ, Fry BG.   +5 more
europepmc   +2 more sources