Results 91 to 100 of about 10,523,720 (359)

Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan

The Pediatric Infectious Disease Journal, 2020
Supplemental Digital Content is available in the text. Background: Information regarding viral shedding in children with coronavirus disease 2019 (COVID-19) was limited.
Yingying Lu, Yi Li, Wenyue Deng, Mingyang Liu, Yuanzhi He, Lingyue Huang, Mengxue Lv, Jianxin Li, Hao Du   +8 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The state of biosafety across China's CDC microbiology laboratories: insights from a nationwide survey (2021–2023)

Frontiers in Public Health
BackgroundThe COVID-19 pandemic underscored the critical importance of biosafety in microbiology laboratories worldwide. In response, China has ramped up its efforts to enhance biosafety measures within its Centers for Disease Control and Prevention (CDC)
Peihua Niu, Zhenlu Sun, Ruiqing Zhang, Yiming Zhao, Fengyu Tian, Ping Cheng, Hongmei Zheng, Jianqiang Guo, Meng Zhang, Xuejun Ma, Ji Wang   +10 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Seroprevalence of Poliovirus Antibodies in the United States Population, 2009–2010

BMC Public Health, 2016
Background Polio is eliminated in the United States, with the last indigenous transmission occurring in 1979. However, global eradication of polio has not yet been completed, so importation of poliovirus into the U.S. is still possible.
Gregory S. Wallace, Aaron T. Curns, William C. Weldon, M. Steven Oberste   +3 more
doaj   +1 more source

Knowledge, Attitude, and Practice of Health Workers in a Tertiary Hospital in Ile-Ife, Nigeria, towards Ebola Viral Disease

Journal of Tropical Medicine, 2015
Background. Health workers are more prone to Ebola viral disease (EVD) than the general population. This study assessed the preparedness of health workers in the control and management of EVD. Methods. A descriptive cross-sectional study.
S. olowookere, E. Abioye-Kuteyi, Olusegun Kayode Adepoju, O. Esan, T. Adeolu, Tolulope Adeoye, Adesola Adebayo Adepoju, A. Aderogba   +7 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Epidemiological characteristics of human rabies cases reported by sites in China from 2006 to 2022

BMC Infectious Diseases
Background Rabies is an incessant public health threat in China. The Ministry of Health implemented the Central Payment for Rabies Prevention and Control Project to assist with rabies prevention and control in a few representative provinces in 2006 ...
Jia-Jia Liu, Na Zhang, Shu-Jun Ding, Zeng-Qiang Kou, Xiao-Yan Tao, Wu-Yang Zhu   +5 more
doaj   +1 more source

World Health Organization Estimates of the Global and Regional Disease Burden of 22 Foodborne Bacterial, Protozoal, and Viral Diseases, 2010: A Data Synthesis

PLoS Medicine, 2015
Background Foodborne diseases are important worldwide, resulting in considerable morbidity and mortality. To our knowledge, we present the first global and regional estimates of the disease burden of the most important foodborne bacterial, protozoal, and
M. Kirk, S. Pires, R. Black, M. Caipo, J. Crump, B. Devleesschauwer, D. Döpfer, A. Fazil, Christa L. Fischer-Walker, T. Hald, A. Hall, K. Keddy, R. Lake, C. Lanata, P. Torgerson, A. Havelaar, F. Angulo   +16 more
semanticscholar   +1 more source