Results 161 to 170 of about 240,853 (262)

Genomic Surveillance of Respiratory Syncytial Virus in Sydney Reveals Rebound in Postpandemic Viral Diversity. [PDF]

Open Forum Infect Dis
Herkes JMS, Foster CSP, Michie A, Bartlett AW, Rawlinson WD, Walker GJ.   +5 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

EBV genome analysis in multiple sclerosis shows extensive viral diversity and links to autoimmunity. [PDF]

NAR Mol Med
Lehikoinen J, Hannolainen L, Rautila OS, Dickson ZW, Pyöriä L, Dieterich L, Jansson L, Tammi S, Hedman K, Perdomo MF, Tienari PJ.   +10 more
europepmc   +1 more source

Genetic and immunological characterization of new subtype G envelope expressing HIV-1 pseudoviruses

, 2014
Includes bibliographical references.One of the greatest challenges for the development of an effective HIV-1 vaccine is the high genetic diversity of this pathogen and the complex escape mechanisms employed by the envelope gp120 and gp41 glycoprotein ...
Essomba, Rene Ghislain
core  

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Metagenomic Sequencing Reveals the Viral Diversity of Bactrian Camels in China. [PDF]

Microorganisms
Li J, Hou L, Liu Y, Sun Y, Li Y, He B, Tu C, Zhou X.   +7 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Healthy pangolin virome reveals mammalian viral diversity and zoonotic risk. [PDF]

Microbiome
Dong T, Wang Q, Que T, Si H, Su J, Chen Y, Yang K, Li C, Qin M, Li B, Zhu Y, Li S, Li Y, He M, Zhong Y, Xiao Q, Hu B, Zeng L.   +17 more
europepmc   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Metagenomic analysis of viral diversity in Portuguese bats. [PDF]

Vet Res Commun
Hemnani M, Karatas M, Cruz AVS, da Silva PG, Thompson G, Poeta P, Rebelo H, Matthijnssens J, Mesquita JR.   +8 more
europepmc   +1 more source