Results 191 to 200 of about 2,646,395 (299)

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Editorial overview: Viral immunology: Generating immunity to diverse viral pathogens

Current Opinion in Virology, 2018
Hickman, Heather D, Suthar, Mehul S
openaire   +2 more sources

EBV genome analysis in multiple sclerosis shows extensive viral diversity and links to autoimmunity. [PDF]

NAR Mol Med
Lehikoinen J, Hannolainen L, Rautila OS, Dickson ZW, Pyöriä L, Dieterich L, Jansson L, Tammi S, Hedman K, Perdomo MF, Tienari PJ.   +10 more
europepmc   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Healthy pangolin virome reveals mammalian viral diversity and zoonotic risk. [PDF]

Microbiome
Dong T, Wang Q, Que T, Si H, Su J, Chen Y, Yang K, Li C, Qin M, Li B, Zhu Y, Li S, Li Y, He M, Zhong Y, Xiao Q, Hu B, Zeng L.   +17 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Expanding known viral diversity [PDF]

Nature Methods, 2016
openaire   +1 more source

Integrated surveillance of arboviruses in febrile patients from the Brazilian Amazon reveals complex co-circulation dynamics and hidden viral diversity. [PDF]

Rev Soc Bras Med Trop
Chavarría KJS, Gomes EO, Chaves BA, Sampaio VS, Silva-Neto AV, Brito D, Silva LFAD, Dias MYO, Sacchetto L, Bernardi V, Marques BC, Buenemann M, Vasilakis N, Nogueira ML, Lacerda MVG, Mourão MPG, Baía-da-Silva DC.   +16 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Metaviromic analysis of Ixodes ticks in Northwestern Russia reveals high viral diversity and novel RNA virus lineages. [PDF]

Sci Rep
Gladkikh AS, Naydenov DD, Sharova AA, Popova MR, Arbuzova TV, Klyuchnikova EO, Sbarzaglia VA, Gibitova EA, Forghani M, Tokarevich NK, Lunina GA, Ramsay ES, Dedkov VG.   +12 more
europepmc   +1 more source