Results 221 to 230 of about 60,752 (282)

Respiratory pandemic risk in the Anthropocene: A One Health framework and GISRS+ agenda. [PDF]

One Health
Lee JM, Kim HO, Kim YJ, Singh MK, Kim SS, Yeo SG.   +5 more
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Phylogeography and molecular evolution of Newcastle disease virus across a century of global surveillance. [PDF]

Virus Res
Ul-Rahman A, Shabbir MZ, Munir M.
europepmc   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Avian influenza and One Health: bridging animal and human health through integrated surveillance and vaccination. [PDF]

Front Cell Infect Microbiol
Pardini A, Garnhartner RL, Vogel M, Bachmann MF.   +3 more
europepmc   +1 more source

Rapid maternal death surveillance and response during a hepatitis E virus outbreak in Madani, Al Jazera state, Sudan

International Journal of Gynecology &Obstetrics, EarlyView.
Mawda Alshaarany, Benjamin Black, Gillian Burkhadt, Noor Rijnberg, Abrar Abdelsalam Zakria Sharif, Maura Daly, Gautam Harigovind, Ali Almohammed   +7 more
wiley   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Global Patterns of Geographic Distribution, Temporal Trends, Host Spectrum, and Molecular Variation of H9N2 Avian Influenza Virus, 1966-2023. [PDF]

Viruses
Chang L, Ren X, Han L, Xia C, Zhao Y.
europepmc   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source

Epidemiology of human RSV in Taiwan, 2018-2024. [PDF]

PLoS One
Yang SL, Liu MT, Huang HH, Lin SW, Li YT, Cheng YH, Wu FT.   +6 more
europepmc   +1 more source