Results 101 to 110 of about 299,371 (295)
Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages
, 2021 Infections with viral pathogens are widespread and can cause a variety of different diseases. In-depth knowledge about viral triggers initiating an immune response is necessary to decipher viral pathogenesis.
Sandra Winter +8 more
core +1 more source
BST2/Tetherin enhances entry of human cytomegalovirus.
PLoS Pathogens, 2011 Interferon-induced BST2/Tetherin prevents budding of vpu-deficient HIV-1 by tethering mature viral particles to the plasma membrane. BST2 also inhibits release of other enveloped viruses including Ebola virus and Kaposi's sarcoma associated herpesvirus ...
Kasinath Viswanathan +5 more
doaj +1 more source
Viral entry mechanisms: the role of molecular simulation in unlocking a key step in viral infections. [PDF]
FEBS Open BioViral infections are a major global health concern, affecting millions of people each year. Viral entry is one of the crucial stages in the infection process, but its details remain elusive. Enveloped viruses are enclosed by a lipid membrane that protects their genetic material and these viruses are linked to various human illnesses, including ...
Valério M +4 more
europepmc +5 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Simulation results for different viral entry points.
, 2015 Simulation results of cellular space fraction, Sc, for DSP and tongue over a 48 hour timescale for maximal replication rate, ξ, and rate of FMDV resource consumption, ρ, both set at 0.29 × their default estimates.
Kyriaki Giorgakoudi (802788) +5 more
core +1 more source
Progress in the use of adeno-associated viral vectors for gene therapy [PDF]
, 2004 The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco +5 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Characterization of Viral Entry Inhibitors [PDF]
, 2015 Hepatitis C virus (HCV), Human Immunodeficiency virus (HIV) and Herpes Simplex virus (HSV) are pathogenic viruses known to cause liver disorder, acquired immunodeficiency and skin lesions, respectively.
Chamoun Emanuelli, Ana M
core
Broad-spectrum Respiratory Virus Entry Inhibitors
, 2022 With the increasing global human population, travel and socioeconomic activities, more and more novel pathogenic viruses will emerge or re-emerge. While more than 260 viruses are known to infect humans, only a small minority of these viral diseases are ...
Zhao, H, Yuen, KY
core +1 more source
ACE2-independent entry factors for SARS-CoV-2 infection and immune activation
mBioSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), remains a major public health threat, particularly in vulnerable populations.
Yiyu Sun +2 more
doaj +1 more source