Results 131 to 140 of about 1,846,216 (386)

Rat Cytomegalovirus Virion-Associated Proteins R131 and R129 Are Necessary for Infection of Macrophages and Dendritic Cells

Pathogens, 2020
Cytomegalovirus (CMV) establishes persistent, latent infection in hosts, causing diseases in immunocompromised patients, transplant recipients, and neonates.
Iris K. A. Jones, Nicole N. Haese, Philippe Gatault, Zachary J. Streblow, Takeshi F. Andoh, Michael Denton, Cassilyn E. Streblow, Kiley Bonin, Craig N. Kreklywich, Jennifer M. Burg, Susan L. Orloff, Daniel N. Streblow   +11 more
doaj   +1 more source

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

Tetraspanins: Architects of Viral Entry and Exit Platforms

Journal of Virology, 2018
Host factors render cells susceptible to viral infection. One family of susceptibility factors, the tetraspanin proteins, facilitate enveloped virus entry by promoting virus-cell membrane fusion.
Michael P Hantak, Enya Qing, J. T. Earnest, T. Gallagher   +3 more
semanticscholar   +1 more source

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

Nature Microbiology, 2020
Over the past 20 years, several coronaviruses have crossed the species barrier into humans, causing outbreaks of severe, and often fatal, respiratory illness. Since SARS-CoV was first identified in animal markets, global viromics projects have discovered
M. Letko, A. Marzi, V. Munster
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Critical amino acid residues in human ACE2 for SARS-CoV-2 spike protein binding and virus entry

Microbiology Spectrum
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), remains a significant global public health concern due to the continuous emergence and rapid spread of new variants.
Weiyi Chen, Joo-Youn Lee, Jae-Sung Kim, Jin Soo Shin, To Sing Fung, Jung-Yong Yeh, Zhenhai Chen, Bin Zhou, Ji-Joon Song, Yun Young Go   +9 more
doaj   +1 more source

Herpes Simplex Virus Glycoprotein C Regulates Low-pH Entry

mSphere, 2020
Herpes simplex viruses (HSVs) cause significant morbidity and mortality in humans worldwide. Herpesviruses mediate entry by a multicomponent virus-encoded machinery.
Tri Komala Sari, Katrina A. Gianopulos, Darin J. Weed, Seth M. Schneider, Suzanne M. Pritchard, Anthony V. Nicola   +5 more
doaj   +1 more source

Theoretical Studies of the Mechanisms of the Entry of Virus into Cells [PDF]

, 2014
Viruses cause human diseases by entering in to human cells. Many drugs have been developed that act at various stages of viral infection, but they fail due to their toxic side effects and high mutation rates of viruses.
Mulampaka, Shiva Naresh
core   +1 more source

Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry.

Annual review of nutrition, 2018
Because both the host and pathogen require iron, the innate immune response carefully orchestrates control over iron metabolism to limit its availability during times of infection. Nutritional iron deficiency can impair host immunity, while iron overload
M. Wessling-Resnick
semanticscholar   +1 more source

Poliovirus Cell Entry: Common Structural Themes in Viral Cell Entry Pathways [PDF]

Annual Review of Microbiology, 2002
▪ Abstract  Structural studies of polio- and closely related viruses have provided a series of snapshots along their cell entry pathways. Based on the structures and related kinetic, biochemical, and genetic studies, we have proposed a model for the cell entry pathway for polio- and closely related viruses.
openaire   +2 more sources