Results 181 to 190 of about 1,846,216 (386)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Development of SARS-CoV-2 entry antivirals

Cell Insight
The global outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatened human health and public safety. The development of anti-SARS-CoV-2 therapies have been essential to curb the spread of SARS-CoV-2. Particularly, antivirals
Meiyue Dong, Jazmin M. Galvan Achi, Ruikun Du, Lijun Rong, Qinghua Cui   +4 more
doaj   +1 more source

Cellular and viral determinants of retroviral nuclear entry [PDF]

, 2015
Faysal Bin Hamid, Jinsun Kim, Cha‐Gyun Shin   +2 more
openalex   +1 more source

Impact of Comorbidities on SARS-CoV-2 Viral Entry-Related Genes [PDF]

, 2020
Joshua D. Breidenbach, Prabhatchandra Dube, Subhanwita Ghosh, Nikolai N. Modyanov, Deepak Malhotra, Lance D. Dworkin, Steven T. Haller, David J. Kennedy   +7 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Macrophage Receptors for Influenza A Virus: Role of the Macrophage Galactose-Type Lectin and Mannose Receptor in Viral Entry [PDF]

, 2010
Jacqueline Upham, Danielle L Pickett, Tatsuro Irimura, E M Anders, Patrick C. Reading   +4 more
openalex   +1 more source

In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry

, 2021
Melina Vallbracht, Henriette Lötzsch, Barbara G. Klupp, Walter Fuchs, Benjamin Vollmer, Kay Grünewald, Marija Backović, F.A. Rey, Thomas C. Mettenleiter   +8 more
openalex   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Gateway to the lungs: Viral entry receptors and susceptibility to COVID‐19 [PDF]

, 2021
Hugo Farne, Aran Singanayagam
openalex   +1 more source