Results 341 to 350 of about 1,846,216 (386)
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2015
Epstein-Barr virus primarily, though not exclusively, infects B cells and epithelial cells. Many of the virus and cell proteins that are involved in entry into these two cell types in vitro have been identified, and their roles in attachment and fusion are being explored.
Liudmila S, Chesnokova +2 more
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Epstein-Barr virus primarily, though not exclusively, infects B cells and epithelial cells. Many of the virus and cell proteins that are involved in entry into these two cell types in vitro have been identified, and their roles in attachment and fusion are being explored.
Liudmila S, Chesnokova +2 more
openaire +2 more sources
Tight Junctions and Viral Entry
Future Virology, 2010A wide variety of different viruses use tight junction (TJ) proteins in the course of infection and different mechanisms of pathogen–TJ interactions have been described; pathogens may induce the reorganization or degradation of distinct TJ proteins, reorganization of the cell cytoskeleton, activation of host-cell signaling pathways and/or use TJ ...
ZEISEL M.B., TUREK M., BAUMERT T.F.
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Computational methods to study enveloped viral entry
Biochemical Society Transactions, 2021The protein–membrane interactions that mediate viral infection occur via loosely ordered, transient assemblies, creating challenges for high-resolution structure determination. Computational methods and in particular molecular dynamics simulation have thus become important adjuncts for integrating experimental data, developing mechanistic models, and ...
Alzbeta Tuerkova, Peter M. Kasson
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2008
The entry of viruses into target cells involves a complex series of sequential steps, with opportunities for inhibition at every stage. Entry inhibitors exert their biological properties by inhibiting protein-protein interactions either within the viral envelope (Env) glycoproteins or between viral Env and host-cell receptors.
Tom, Melby, Mike, Westby
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The entry of viruses into target cells involves a complex series of sequential steps, with opportunities for inhibition at every stage. Entry inhibitors exert their biological properties by inhibiting protein-protein interactions either within the viral envelope (Env) glycoproteins or between viral Env and host-cell receptors.
Tom, Melby, Mike, Westby
openaire +2 more sources
AIP Conference Proceedings, 2010
Successful viral infection of a healthy cell requires complex host‐pathogen interactions. In this talk we focus on the dynamics specific to the HIV virus entering a eucaryotic cell. We model viral entry as a stochastic engagement of receptors and coreceptors on the cell surface.
Maria R. D’Orsogna +3 more
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Successful viral infection of a healthy cell requires complex host‐pathogen interactions. In this talk we focus on the dynamics specific to the HIV virus entering a eucaryotic cell. We model viral entry as a stochastic engagement of receptors and coreceptors on the cell surface.
Maria R. D’Orsogna +3 more
openaire +1 more source
New England Journal of Medicine, 2004
Until recently, antiviral drugs were both uncommon and not terribly potent. This has changed: during the past decade, more than 30 antiviral drugs have been licensed, and many of them are very effe...
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Until recently, antiviral drugs were both uncommon and not terribly potent. This has changed: during the past decade, more than 30 antiviral drugs have been licensed, and many of them are very effe...
openaire +2 more sources
Role of Protein–Lipid Interactions in Viral Entry
Advanced Biology, 2022AbstractThe viral entry consists of several sequential events that ensure the attachment of the virus to the host cell and the introduction of its genetic material for the continuation of the replication cycle. Both cellular and viral lipids have gained a wider focus in recent years in the field of viral entry, as they are found to play key roles in ...
Jon Ander Nieto‐Garai +3 more
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HIV-Resistance to Viral Entry Inhibitors
Current Pharmaceutical Design, 2004An increasing number of human immunodeficiency virus (HIV)-infected patients have detectable viraemia despite treatment with multiple-drug combinations or have developed resistance to all available classes of antiretroviral therapy. HIV entry has become an important pharmacological target. Enfuvirtide is the first HIV entry inhibitor to be approved for
Luis, Menéndez-Arias, José A, Esté
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Henipavirus Membrane Fusion and Viral Entry
2012Nipah (NiV) and Hendra (HeV) viruses cause cell-cell fusion (syncytia) in brain, lung, heart, and kidney tissues, leading to encephalitis, pneumonia, and often death. Membrane fusion is essential to both viral entry and virus-induced cell-cell fusion, a hallmark of henipavirus infections.
Hector C, Aguilar, Ronald M, Iorio
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HIV-1 cell entry and advances in viral entry inhibitor therapy
Journal of Clinical Virology, 2003Despite the considerable successes of highly active antiretroviral therapy, new classes of therapeutic agents are still urgently needed. Unfortunately, the emergence of antiviral resistance and drug toxicity remain challenging obstacles to successful treatment in many HIV-1-infected individuals. HIV-1 entry is a multi-step process that is an attractive
Louise A, Cooley, Sharon R, Lewin
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