Results 191 to 200 of about 146,326 (305)
Viral envelope proteins fused to multiple distinct fluorescent reporters to probe receptor binding. [PDF]
Protein SciTomris I +5 more
europepmc +1 more source
Heparanase attenuates Zika virus infection by destabilizing the viral envelope protein
Abstract Heparanase (Hpa) is the only endoglycosidase enzyme in mammalian cells capable of cleaving heparan sulfate. In addition to its well-known functions in the regulation of glycosaminoglycans integrity, accumulating evidence indicates that Hpa plays vital roles in viral infection, while the mechanisms are not yet
Jiaxin Ling +3 more
openaire +1 more source
Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms
Allergy, EarlyView.Short‐term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real‐time electrical impedance spectroscopy. SDS‐induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways ...
Manru Li +10 more
wiley +1 more source
Background Neutralizing antibodies against PRRSV are capable of conferring protection against viral reinfection, but they tend to be strain specific and usually have poor cross-reactivity.
Simarro Fernández, María Isabel +5 more
core +1 more source
Allergy, EarlyView.Young children (0–9 years) and residents of urban areas appeared particularly vulnerable to respiratory allergy development and exacerbation. Incidence showed nonlinear associations with PM10, PM2.5, temperature, and alder/birch pollen, while DPMR showed similar patterns, except for NO2 and the interaction O3*NO2.
Trang Dao‐Siebel +6 more
wiley +1 more source
Viral and cellular determinants of polarized trafficking of viral envelope proteins from insect-specific and insect-vectored viruses in insect midgut and salivary gland cells. [PDF]
J VirolHodgson JJ +3 more
europepmc +1 more source
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source
Endogenous Viral Etiology of Prion Diseases
, 2009 Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
The FEBS Journal, EarlyView.Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source