Results 271 to 280 of about 203,793 (303)
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Membrane destabilization by N-terminal peptides of viral envelope proteins
The Journal of Membrane Biology, 1992The fusion of lipid enveloped viruses with cellular membranes is thought to be mediated by the insertion into the target membrane of the N-terminal polypeptides of viral spike glycoproteins. Since membrane destabilization is a necessary step in membrane fusion, we investigated whether synthetic peptides with amino acid sequences corresponding to the N ...
N, Düzgüneş, S A, Shavnin
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Lysis of retroviruses with monoclonal antibodies against viral envelope proteins
Virology, 1980Abstract Monoclonal antibodies identifying six independent antigenic determinants (epitopes) on the gp70 and p15(E) envelope proteins of murine leukemia virus were tested for their ability to lyse a panel of serologically different [3H]uridine-labeled retroviruses in the presence of complement.
S, Oroszlan, R C, Nowinski
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Epitope mapping of the gp53 envelope protein of bovine viral diarrhea virus
Virology, 1992Epitopes recognized by nine monoclonal antibodies (mAbs) on the envelope protein, gp53, of two strains of bovine viral diarrhoea virus (NADL and Oregon C24V) were mapped by competitive binding assays and by the characterization and sequence analyses of mAb neutralization escape mutants.
D J, Paton, J P, Lowings, A D, Barrett
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A Dissection of Steps Leading to Viral Envelope Protein‐Mediated Membrane Fusion
Annals of the New York Academy of Sciences, 1991increase in [Ca”] at the presynaptic nerve terminal sets a complex set of biochemical events in motion that finally terminates in the specific fusion of the membrane of the secretory vesicle with the plasma membrane.’ In studying the action of CaZ+ at the presynaptic terminal a distinction has to be made between processes that occur in the cytosol that
R, Blumenthal +3 more
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Cell Biophysics, 1991
A comparison of the MMTV and MuLVenelope proteins in W7MG1 cells indicates that within the same cell some proteins are processed and sorted constitutively in the ER/Golgi system, whereas other proteins are processed in a hormone-dependent manner. The requisite hormone-dependent step in MMTV envelope protein processing occurs relatively early in the ...
M R, Stallcup, J L, Corey, R M, Bedgood
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A comparison of the MMTV and MuLVenelope proteins in W7MG1 cells indicates that within the same cell some proteins are processed and sorted constitutively in the ER/Golgi system, whereas other proteins are processed in a hormone-dependent manner. The requisite hormone-dependent step in MMTV envelope protein processing occurs relatively early in the ...
M R, Stallcup, J L, Corey, R M, Bedgood
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On The Role of Viral Envelope Proteins in Pathogenesis
1984The paramyxovirus envelope contains two surface glycoproteins (HN and F) and an internal non-glycosylated protein (M). The F protein is involved in viral pathogenesis in three different ways, each related to its ability to cause membrane fusion, which mediates virus penetration, cell fusion, and hemolysis. 1.
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Enveloped Viral Replica Equipped with Spike Protein Derived from SARS-CoV-2
ACS Synthetic BiologySynthetic viral nanostructures are useful as materials for analyzing the biological behavior of natural viruses and as vaccine materials. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus embedding a spike (S) protein involved in host cell infection.
Hiroto Furukawa +8 more
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Role of the N-terminal peptides of viral envelope proteins in membrane fusion
Advanced Drug Delivery Reviews, 1999Membrane fusion is an important biological process that is observed in a wide variety of intra and intercellular events. In this review, work done in the last few years on the molecular mechanism of viral membrane fusion is highlighted, focusing in particular on the role of the fusion peptide and the modification of the lipid bilayer structure.
Martin, Isabelle +2 more
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Peptide-Based Inhibitors of the HIV Envelope Protein and Other Class I Viral Fusion Proteins
Current Pharmaceutical Design, 2010Viruses need to deliver their genomic information into the host cell lumen to establish productive infection. Enveloped viruses accomplish this task by fusing their membrane with a host cell membrane. Membrane fusion is facilitated by specialized viral membrane proteins, which mediate binding and entry into host cells.
Imke, Steffen, Stefan, Pöhlmann
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Enhanced cellular secretion of AAV2 by expression of foreign viral envelope proteins
Biochemical Engineering Journal, 2015Abstract Recombinant adeno-associated virus (rAAV), a non-enveloped virus, is widely used in gene therapy clinical trials because it does not cause human disease, transduces both dividing and non-dividing cells, and mediates stable transgene expression for years in post-mitotic tissue.
Melissa A. Kotterman +6 more
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