Results 1 to 10 of about 4,157,188 (215)

Defensin-driven viral evolution. [PDF]

PLoS Pathogens, 2020
Enteric alpha-defensins are potent effectors of innate immunity that are abundantly expressed in the small intestine. Certain enteric bacteria and viruses are resistant to defensins and even appropriate them to enhance infection despite neutralization of
Karina Diaz, Ciara T Hu, Youngmee Sul, Beth A Bromme, Nicolle D Myers, Ksenia V Skorohodova, Anshu P Gounder, Jason G Smith   +7 more
doaj   +5 more sources

Statistical mechanics and thermodynamics of viral evolution [PDF]

PLOS ONE, 2015
This paper analyzes a simplified model of viral infection and evolution using the 'grand canonical ensemble' and formalisms from statistical mechanics and thermodynamics to enumerate all possible viruses and to derive thermodynamic variables for the ...
Bianco, Simone, Jones, Barbara A., Kaufman, James H., Lessler, Justin   +3 more
core   +14 more sources

Virus satellites drive viral evolution and ecology [PDF]

PLOS Genetics, 2015
Virus satellites are widespread subcellular entities, present both in eukaryotic and in prokaryotic cells. Their modus vivendi involves parasitism of the life cycle of their inducing helper viruses, which assures their transmission to a new host. However,
Buckling, Angus, Donderis, Jorge, Elena, Santiago F., Frígols, Belén, Marina, Alberto, Mir-Sanchis, Ignacio, Novick, Richard P., Penades, Jose R., Quiles-Puchalt, Nuria   +8 more
core   +10 more sources

Viral Evolution Shaped by Host Proteostasis Networks. [PDF]

Annu Rev Virol, 2023
Understanding the factors that shape viral evolution is critical for developing effective antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One fundamental determinant of viral evolution is the interplay between viral
Yoon J, Patrick JE, Ogbunugafor CB, Shoulders MD.   +3 more
europepmc   +2 more sources

Conserved untranslated regions of multipartite viruses: Natural markers of novel viral genomic components and tags of viral evolution. [PDF]

Virus Evol, 2022
Viruses with split genomes are categorized as being either segmented or multipartite according to whether their genomic segments occur in single or different virions.
Zhang S, Yang C, Qiu Y, Liao R, Xuan Z, Ren F, Dong Y, Xie X, Han Y, Wu D, Ramos-González PL, Freitas-Astúa J, Yang H, Zhou C, Cao M.   +14 more
europepmc   +2 more sources

Detection of Ancient Viruses and Long-Term Viral Evolution. [PDF]

Viruses, 2022
The COVID-19 outbreak has reminded us of the importance of viral evolutionary studies as regards comprehending complex viral evolution and preventing future pandemics. A unique approach to understanding viral evolution is the use of ancient viral genomes.
Nishimura L, Fujito N, Sugimoto R, Inoue I.   +3 more
europepmc   +2 more sources

Global epidemiology, viral evolution, and public health responses: a systematic review on Mpox (1958-2024). [PDF]

J Glob Health
Background Monkeypox (Mpox), a zoonotic viral disease caused by the Mpox virus (MPOXV), was first identified in 1958 and remained largely confined to Central and West Africa for decades.
Jadhav V, Paul A, Trivedi V, Bhatnagar R, Bhalsinge R, Jadhav SV.   +5 more
europepmc   +2 more sources

Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants. [PDF]

Nat Microbiol
Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 receptor-binding domain are used to treat and prevent COVID-19. However, the rapid evolution of SARS-CoV-2 drives continuous escape from therapeutic mAbs.
Jian F, Wec AZ, Feng L, Yu Y, Wang L, Wang P, Yu L, Wang J, Hou J, Berrueta DM, Lee D, Speidel T, Ma L, Kim T, Yisimayi A, Song W, Wang J, Liu L, Yang S, Niu X, Xiao T, An R, Wang Y, Shao F, Wang Y, Pecetta S, Wang X, Walker LM, Cao Y.   +28 more
europepmc   +2 more sources

Within-Host Viral Diversity: A Window into Viral Evolution.

Annual Review of Virology, 2020
The evolutionary dynamics of a virus can differ within hosts and across populations. Studies of within-host evolution provide an important link between experimental studies of virus evolution and large-scale phylodynamic analyses.
A. Lauring
semanticscholar   +3 more sources

Topology of viral evolution [PDF]

Proceedings of the National Academy of Sciences, 2013
SignificanceEvolution is mediated not only by random mutations over a number of generations (vertical evolution), but also through the mixture of genomic material between individuals of different lineages (horizontal evolution). The standard evolutionary representation, the phylogenetic tree, faithfully represents the former but not the latter scenario.
Joseph Chan, G. Carlsson, R. Rabadán
semanticscholar   +4 more sources