Results 91 to 100 of about 4,157,307 (334)
Efficient evolution of human antibodies from general protein language models
Nature Biotechnology, 2023 A general protein language model guides protein evolution with 20 or fewer variants needed for testing. Natural evolution must explore a vast landscape of possible sequences for desirable yet rare mutations, suggesting that learning from natural ...
Brian L. Hie +8 more
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
mBio, 2019 Influenza A viruses are important pathogens for humans and for many birds and mammals. Hemagglutinin and neuraminidase are the major surface proteins of this enveloped RNA virus. Hemagglutinin requires proteolytic cleavage for activation, but because the
Jeffery K. Taubenberger
doaj +1 more source
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. [PDF]
, 2009 Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution
Dever, Thomas E +4 more
core
Mobile Genetic Elements, 2012 Explaining the origin of viruses remains an important challenge for evolutionary biology. Previous explanatory frameworks described viruses as founders of cellular life, as parasitic reductive products of ancient cellular organisms or as escapees of modern genomes.
Nasir, Arshan +2 more
openaire +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The Historical Case for and the Future Study of Antibiotic-Resistant Scrub Typhus
Tropical Medicine and Infectious Disease, 2017 Scrub typhus is an acute, and sometimes fatal, human febrile illness, typically successfully treated using chloramphenicol or one of the tetracyclines.
Daryl J. Kelly +2 more
doaj +1 more source
Frontiers in Microbiology, 2021 An unprecedented amount of SARS-CoV-2 sequencing has been performed, however, novel bioinformatic tools to cope with and process these large datasets is needed.
Carlos Farkas +7 more
doaj +1 more source
Infection, Genetics and Evolution, 2015 Porcine circovirus type 2 is one of the most widespread and economically relevant infections of swine. Four genotypes have been recognized, but currently, only three (PCV2a, PCV2b and PCV2d) are effectively circulating. The widespread livestock trade and
G. Franzo +5 more
semanticscholar +1 more source
Viral Recombination: Ecology, Evolution, and Pathogenesis [PDF]
Viruses, 2018 Recombination between and within virus genomes is being increasingly recognized as a majordriver of virus evolution.
openaire +3 more sources